[Comparative results in the initial treatment of pulmonary tuberculosis using a new and classical antitubercular agent].
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Biomedical subjects
Publications and source records attributed to R Milutinović.
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Physical examination, X-ray and lung function studies were performed in a group of 29 patients with chronic obstructive lung diseases. According to the diffusing capacity, patients were divided into two subgroups: one with normal and the other with decreased lung transfer-factor. Comparing the parameters of pulmonary function significantly more severe obstructive ventilatory insufficiency and greater lung hyperinflation were found in the subgroup of patients with decreased diffusing capacity. In this subgroup the collapsing type of flow-volume loop and X-ray signs of emphysema were present more frequently than in patients with normal lung diffusing capacity.
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Pulmonary function in 25 patients with a severe degree of kyphoscoliosis was studied. Severe restrictive ventilatory insufficiency and hypoxaemic-hypercapnic respiratory failure were discovered. Isolated deformities of the vertebral column were diagnosed in 15 patients while ten patients, apart from diagnosed kyphoscoliosis, had associated chronic obstructive pulmonary diseases. Significant differences in pulmonary function impairment between these two groups, i.e. patients with associated chronic obstructive pulmonary disease, were observed. This indicates that associated pulmonary disease accelerates the development and course of respiratory failure. Respiratory blood gas analysis in 11 patients over the course of two years showed significant worsening of hypoxaemia and hypercapnia, which implies that in patients with kyphoscoliosis the disease has a rapid progression once the respiratory failure develops.