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Biomedical subjects

R Michiels

Publications and source records attributed to R Michiels.

At least 37 records · Page 2Linked to original sources
PubMed1986

Incidence of hematopoietic malignancies in a well-defined population in France.

A registration of hematopoietic malignancies was established on January 1, 1980, in order to determinate accurately the incidence and epidemiological features of these diseases in the department of Côte d'Or (population 477,908). Information was collected from various sources (public and private laboratories, hospitals, general practitioners and death certificates). Over a 3-year period (1980-1982), 401 new cases were diagnosed among residents of the department. The crude incidence rates were 32.9/100,000 for males and 23.0/100,000 for females. The corresponding age standardized rates (using world standard population) were 26.1 and 15.9, respectively. The sex ratio was 1.8:1. In males, chronic lymphocytic leukemias, Hodgkin's and non-Hodgkin's lymphomas are the most common hematopoietic malignancies, followed by acute leukemias and multiple myelomas. In females, lymphomas are more frequent than acute leukemias, chronic lymphocytic leukemias and multiple myelomas. Compared to population based registries in other countries, incidence rates are among the highest reported, and are particularly high for chronic lymphocytic leukemia.

Adult↗
PubMed1986

[Does Ming's classification of gastric carcinomas have epidemiologic or prognostic value?].

The population based registry of digestive tract tumours of the country of Cote-d'Or was used to assess the epidemiological and prognostic value of Ming classification. The 211 gastric carcinomas operated or autopsied between 1976 and 1981 in this population were reviewed on a pathological basis. The expansive type (46.0%) was nearly as frequent as the infiltrative type (47.9%). In 6.2% of the cases it was impossible to classify carcinomas in one of these two types. The male/female ratio was higher in the expansive type (3.0) than in the infiltrative type (2.2) and the mean age of patients at the time of diagnosis was higher in the expansive type (69.5 years) than in the infiltrate type (66.4 years p less than 0,05). Ming classification was difficult to use with superficial carcinomas: 9 out of 12 could not be classified. Among invasive cancers only 1.5% were not classified in one of the two types. Polypoid and fungating carcinomas were more often of the expansive type (70.1%). On the contrary infiltrative carcinomas (ulcerated or not) corresponded to the infiltrative type of Ming in 65.6%. It was not possible to extrapolate the WHO classification to the Ming classification. Infiltrative carcinomas were more often associated with hyperplastic stroma (38.1%) than did expansive carcinomas (5.2%) the proportion of carcinomas limited to the digestive wall was higher in the expansive type (21.7%) than in the infiltrative type (5.0%). The survival rate was better in the expansive type (41.4%) than in the infiltrative type (30.1%) but the difference was not significant. The prognosis depended partly on the time of diagnosis. The results suggest that Ming classification has an epidemiological interest. It allows us to distinguish two types of carcinomas that appear quite different on basis of their growth and penetration capacity. However its prognostic interest appears limited.

Adult↗
PubMed1985

[9 years of systematic cytologic examinations of expressed galactophorous discharge. Detection of cancerous and precancerous conditions].

Nine years of experience performing cytologic examinations on expressed breast discharge has enabled the identification of precancerous and cancerous conditions of the breast. Three thousand women were monitored. The only abnormal findings were cytologic (clinical and radiological examinations were normal). One case of atypical hyperplasia, 3 cases of cancer in situ, and 2 invasive cancers were identified upon histologic examination. Three women were lost to follow-up and subsequently developed invasive cancer.

Adult↗
PubMed1985

[The "white" cervix: a new anatomo-clinical entity?].

The authors describe a very particular histologic pattern of the cervical epithelium. Many types of histologic lesions are involved and are almost always found in association one with another. This particular histologic pattern is characterized principally by well-differentiated epithelium, immature, with early necrosis of the superficial layers, associated with metaplastic endocervicitis. In addition to this particular association, there is a remarkable finding: this histologic pattern was found consistently in fifteen cases selected uniquely from their appearance at colposcopy. Could this be a new anatomic-histologic entity?

Acetates↗
PubMed1982

[Benign clear cell tumour of the lung (author's transl)].

The benign clear cell tumor of the lung is an uncommon neoplasm. It is often confused, before histological analysis, with metastases. The data of one personal observation are similar to those of 19 other cases of the literature. This tumor which occurs with an equal frequency in adults of the two sexes is often asymptomatic. It is discovered after a systematic x-ray control of the lungs. It is located in the peripheral parenchyma and looks like a round, homogeneous, well delimited opacity. Its evolution is always favourable after surgical excision. The benign clear cell tumour is never identified before pathological study. This neoplasm 1 to 6 cm in diameter consists of a uniform proliferation of clear cells filled up with free of intra-vesicular glycogen. Its cytological and structural features are not the same as those of the other primitive bronchopulmonary tumours having an important clear cell contingent. The histochemical and ultra-structural studies are at the origin of three hypotheses; is the benign clear cell tumor an apudoma, a smooth muscular neoplasm or an adenoma of the terminal bronchioles?

Adult↗
PubMed1982

Enhancement of amyloidosis by chenodeoxycholic acid ingestion in the hamster.

A long-term experiment was performed to test the ability of chenodeoxycholic acid (CDCA) to induce intestinal tumors in the Syrian golden hamster. Animals were fed a CDCA-enriched diet up to 12 months, and 4 of them were sacrificed every 2 months. CDCA exhibited no carcinogenic activity. However, unexpected amyloid deposits were discovered in both treated and nontreated animals. Their incidence was significantly higher in treated (71%) than in nontreated (27%) hamsters. During CDCA administration, amyloidosis appeared as early as the second month of treatment. It involved the liver, spleen and kidneys in more than half of the animals. On the contrary, in control animals, amyloid deposits appeared later and were most frequently restricted to one organ. The intensity of the lesions also appeared to be greater in the treated group. No monoclonal components were found in either serum or urine of the amyloidotic hamsters. Such an amyloidosis-promoting effect of CDCA has never been reported.

Administration, Oral↗
PubMed1981

Cancer of the esophagus. An incidence study of Côte d'Or (Burgundy).

The registry of digestive cancer set up for the French department of Côte d'Or (455, 727) enables a morbidity study about esophageal cancer to be made among residents. The crude animal incidence rate was 16.7/100,000 for males and 1.2/100,000 for females. Corresponding age-standardized rates were 13.2 and 0.5. The sex ratio is extremely high. Among other cancer registries Côte d'Or is in the intermediate range for males, and in the low range for females. 40% of tumors were in the middle third, 37% in the lower third, and 23% in the upper third. Most cancers were squamous cell carcinomas (94%). The risk of an associated aerodigestive tract tumor is important (16%). 10% of patients were operated upon for cure, 53% had radiotherapy. The 1 year crude survival rate was 25%.

Adenocarcinoma↗
PubMed1981

[Systematic cytological examination of discharges from the breast in young women. The value of screening for cancer of the breast and for borderline states (author's transl)].

The authors have used the cytological investigation of the liquid discharge from the breast to search systematically for cancerous states and, more usually, for borderline conditions in the breast. Using a simple technique it has been possible to obtain some discharge from the breast more or less easily. In 15 per 1000 cases cytological abnormalities have been found, which means that there were 39 pathological discharges in the 2490 women who were examined over five years. 27 of these were benign lesions and 12 of them were suspect. Of these latter three borderline conditions were found and one invasive cancer was found. All four were asymptomatic. It is therefore worth while examining discharges from the breast in screening for borderline conditions in young women.

Adult↗