Search PubMed⌕ Search

Biomedical subjects

R Mendez

Publications and source records attributed to R Mendez.

At least 127 records · Page 7Linked to original sources
PubMed1978

Sexual function and hormonal abnormalities in uremic men on chronic dialysis and after renal transplantation.

Twenty-one adult uremic males on chronic hemodialysis were studied to determine the circulating levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and prolactin and their relationship to sexual function. Ten of the twenty-one patients were on exogenous testosterone, and its effects were measured. Twelve adult males with successful renal transplants were likewise examined. Testosterone concentrations were low in dialysis patients not on androgens (429 ng/dl +/- 85 SE), but FSH and LH levels were elevated (8.0 mIU/ml +/- 1.4 SE and 31 mIU/ml +/- 5.4 SE, respectively. Testosterone returned to normal after transplantation, but FSH and LH levels remained elevated. Prolactin levels were significantly increased in dialysis patients (25.5 ng/ml +/- 5.6 SE) and remained so despite androgen therapy, but returned to normal after transplantation. There was no correlation in any group between laboratory data and potency before androgen therapy. However, excessive testosterone replacement was shown to have an adverse effect on potentia.

Adult↗
PubMed1978

The management of delayed recognized ureteral injuries.

Of the 90 cases of ureteral injuries reviewed 51 injuries were recognized immediately, while 39 were recognized in the delayed period. Although the over-all difference in results between those treated immediately and those receiving delayed treatment was relatively small, when the cases were further subdivided by etiology and time of recognition into immediate and delayed iatrogenic injuries and traumatic injuries the difference in results was striking. This fact had been suspected clinically but not well documented previously in the urologic literature.

Humans↗
PubMed1977

Traumatic ureteral injuries with delayed recognition.

Review of ureteral injuries treated in the past ten years at the Los Angeles County-University of Souther California Medical Center revealed 9 cases of traumatic injury which escaped immediate recognition. These patients were found to have a poor prognosis with a higher incidence of nephrectomy when compared with those patients with immediate diagnosis and treatment.

Drainage↗
PubMed1977

Renal trauma.

The pertinent literature on renal trauma for the last 25 years has been analyzed. An evolutionary pattern is seen in the development of diagnostic methods, while surgical and medical management of renal trauma has become much more precise for specific lesions. Various subareas of interest within the field have emerged, such as pediatric trauma, associated injuries and the subdivisions of blunt and penetrating trauma. Furthermore, therapy has been extended to include those severe vascular lesions that previously were considered untreatable. Various new and experimental concepts are described. Specific recommendations regarding the diagnosis and the therapeutic management are offered in an attempt to bring perspective to these new developments.

Adolescent↗
PubMed1975

Renal transplantation. In adult patients with end stage polycystic kidney disease.

Seventeen adult patients with end stage polycystic kidney disease underwent renal transplantation. Two groups were identified: (1) those transplanted with retained polycystic kidneys, (2) those prepared with preliminary bilateral nephrectomy. Although there was a shockingly higher incidence in the mortality rate in the non-nephrectomized group, no specific cause could be identified. The results do indicate, however, that bilateral nephrectomy is essential in all patients with a history of pyelonephritis or gross hematuria. Substantial benefit from retained kidneys was noted only during the initial period of hemodialysis.

Adult↗
PubMed1975

Increased plasma catecholamine concentrations and vas deferens norepinephrine biosynthesis in men with elevated blood pressure.

Systemic biochemical indexes of sympathetic nerve functionplasma catecholamine concentrations and serum dopamine-beta-hydroxylase activitywere correlated with regional indexesnorepinephrine concentration activities of norepinephrine biosynthetic enzymes in the vas deferensānd with blood pressures and pulse rates of 57 men at the time of vasectomy. Mean plasma catecholamine content was increased 66% and 60% in men with elevated systolic and elevated systolic and diastolic blood pressures, respectively. The norepinephrine concentration, tyrosine hydroxylase activity, and dopa decarboxylase activity in the vas deferens were increased in 12%, 26%, and 17% of the men with elevated blood pressure, respectively. Tyrosine hydroxylase and dopa decarboxylase in the men with elevated systolic blood pressure were increased 41% and 68%, respectively, compared with values in the men with normal blood pressure (P less than 0.05 and P less than 0.02). Individual plasma catecholamine content was related directly to both systolic and mean blood pressure (P less than 0.01) and to activities of vas deferens tyrosine hydroxylases (P less than 0.05) and dopa decarboxylase (P less than 0.01). There was a weak, but not significant, correlation of plasma catecholamine concentration with serum dopamine-beta-hydroxylase activity. Raised plasma catecholamine concentration in men with elevated blood pressure prior to vasectomy was associated with increased neurotransmitter biosynthesis in their vas deferens, which may indicate increased sympathetic nerve tonicity and perhaps be a factor contributing to the blood pressure elevation.

Adult↗
PubMed1975

The effects of ajmaline in experimental and clinical arrhythmias and their relation to some electrophysiological parameters of the heart.

The antiarrhythmic efficacy of ajmaline has been evaluated in three experimental models of cardiac arrhythmias in the dog. These data have been related to the actions of the compound on several parameters of heart function and compared to results obtained in various clinical arrhythmias. Ajmaline was more effective in arrhythmias of the ectopic focus type than in the circus movement model. These results agreed with the pattern of clinical activity. The compound produced decreases in excitability and conduction and increased the functional refractory period in all heart tissues. These effects were most marked in the atrium. The drug also showed a moderate degree of anticholinergic activity. Both in the dogs and in the clinical cases, the agent showed an important hypotensive effect. In a group of experiments in which transmembrane potentials were recorded, the compound produced in all tissues a decrease in upstroke velocity and amplitude of the action potential; it also increased the duration of the action potential in atrial and ventricular muscle, but it decreased it in Purkinje fibers. The possible mechanism(s) of action of the drug is discussed in terms of the different hypotheses for cardiac arrhythmias.

Action Potentials↗