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Biomedical subjects

R Menapace

Publications and source records attributed to R Menapace.

At least 109 records · Page 6Linked to original sources

[Current state of implantation of flexible intraocular lenses].

Two main arguments have stimulated the development of hydrogel and silicone lenses: flexibility allows folding and thus insertion through a small incision, and inertness promises excellent biocompatibility, possibly surpassing that of PMMA. However, as long-term performance remains to be established, these implants cannot yet be considered a routine alternative. Clinical studies are mandatory to document their advantages and any disadvantages, especially as few of the reports already published on experience with such lenses do not give an objective picture of the current status: the surgical techniques used and the observation criteria applied differ and were sometimes inappropriate. In addition, the series are too small and the follow-up studies too short to allow valid conclusions. In this paper, following the description of the materials and designs and of the implantation techniques available for flexible lenses, a review of the pertinent literature and the author's own experiences is reported. This is based on 800 implantations performed over a period of 4 years. Monobloc designs with flange haptics (IOGEL, STAAR) have been found to perform best. The Faulkner folder has proved to be optimal, allowing for easy and atraumatic folding and insertion. Within the eye, the lens is safely guided and released. Bag placement of appropriately styled lens models is strongly recommended, since sulcus-placed lenses have sometimes shown either iris bulging or decentration and windshield-wiper or propeller phenomena. The capsular edge should be smooth and the capsular opening well centered and round in order to guarantee stable fixation and symmetrical compression.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

Modified triple procedure using a temporary keratoprosthesis for closed-system, small-incision cataract surgery.

In patients with corneal disease and cataract, the combined surgical approach yields quick rehabilitation and excellent visual results. Working on an open eye for cataract removal and posterior chamber lens implantation, however, makes the procedure risky and difficult. Using a temporary keratoprosthesis and a small-incision technique, surgery can be performed in a fully closed system, optimizing the safety and precision of the procedure.

Aged↗

Evaluation of 150 consecutive cases of poly HEMA posterior chamber lenses implanted in the bag using a small-incision technique.

We report the results of 150 capsular bag implantations of the IOGEL PC-12 hydrogel lens. Mean follow-up was seven months. Following capsulorhexis and phacoemulsification, a Faulkner folder was used to insert the lens through a 3.5 mm to 4.0 mm scleral tunnel incision. Initially, a number of surgical complications were encountered. Because of increasing experience and modified instrumentation and technique, these did not occur in the later cases. Visual results were good, all eyes gaining a best case visual acuity of 20/40 or better and 97% achieving 20/25 or better. Morphological results were satisfactory. Generally the lenses remained centered and at a distance from the iris. Retention of viscoelastic substance or debris between the lens and the posterior capsule, occasionally observed at the start of the series, has been avoided by retrolental aspiration. Persistent pigment dispersion, which was observed when the lens had been implanted in the sulcus, was not seen. Tolerance of the lens material was generally satisfactory. There were six cases (4%) of fibrinoid uveitis, which is a relatively high incidence. From our experience and results we conclude that this implantation procedure allowed controlled insertion and placement of the IOGEL lens, provided that adequate instrumentation and technique was used; visual performance was comparable to that of poly(methyl methacrylate) lenses; capsular bag fixation furnished satisfactory morphological results, provided an adequately shaped capsulorhexis was performed.

Aged↗

[Plexiglass replicas for optimizing selection and site of ruthenium 106 applicators].

Contact irradiation of choroidal tumors using Ruthenium106 applicators has become a well-established treatment modality. In order to destroy all tumor tissue while at the same time sparing the neighboring structures of the eye a plaque has to be placed exactly, just overlapping the tumor's base. With transparent plastic replicas with a dark-colored rim and adequate diaphanoscopy this can be accomplished with an otherwise unattainable degree of precision, while at the same time reducing the radiation dose sustained by the surgeon. The design of the replicas and the localization technique are described in detail.

Brachytherapy↗

Ocular symptomatology in familial hypomelanosis Ito. Incontinentia pigmenti achromians.

Hypomelanosis Ito (HI) is a very rare neurocutaneous syndrome which is often associated with cutaneous, cerebral, musculoskeletal and ocular abnormalities. The paper deals with changes in familial HI (mother and daughter) with special consideration of ocular symptomatology; it also presents a review about the relevant literature published to date--not documented with photographs with one exception. The argument is raised whether all ocular changes described in HI actually belong to the syndrome or are partly a mere coincidence. There is also a description of a cataract which has never been observed in cases of HI. Electrophysiological tests (electroretinography, electro-oculography, visual-evoked potential) which to date have not been carried out for HI, are presented and their results reported. Mention is also made of the hereditary factor which has so far been questioned; it is assumed that it is autosomal dominant in character. In this context, the results of a chromosome analysis in both mother and daughter are presented.

Adult↗

Long-term follow-up of argon laser trabeculoplasty in uncontrolled primary open-angle glaucoma. A study with standardized extensive preoperative treatment.

The long-term results of 180 degrees argon laser trabeculoplasty (ALT) were studied in 61 eyes of 43 patients with uncontrolled primary open-angle glaucoma [intraocular pressure (IOP) less than 22 mm Hg]. In order to enhance the relevance of this prospective study, only eyes that had not responded to medication despite standardized extensive therapy were followed up over an average period of 4.4 years [52.8 +/- 7.3 (mean +/- SD) months]. The success rate of treatment (decrease in IOP less than 5 mm Hg, IOP below 20 mm Hg, stable visual field, stable optic nerve head and no further laser or surgical intervention) after 4.4 years was 73.7%. The mean decrease in IOP was 8.5 +/- 2.9 mm Hg (mean +/- SD). Eyes receiving ALT before cataract surgery retained control of IOP after surgery. A comparable pressure control was also attained with those eyes that had undergone previous trabeculectomy. Failures (26.3%) all occurred in the 1st year after treatment. The results and conclusions from our study are compared with those reported in the literature. The different theories regarding the mechanisms of action of ALT are discussed.

Adult↗

[Brachytherapy using Ru-106 applicators in ophthalmology].

Two Ru-106 applicators of the type CCB as manufactured by the "Zentralinstitut für Isotopen- und Strahlenforschung" (Berlin, GDR) were investigated. The homogeneity of the relative dose distribution at the surface of the applicators was determined. For the evaluation of the data extremely small TLD crystals (2 x 1 x 1 mm) had to be manufactured as well as an almost tissue equivalent acrylic eye phantom. In order to assure reproducibility of the applicator positioning, the plaque suture eyelets had to be placed on locating pins. 120 points of measurements located within the active plaque area of 20 mm diameter were evaluated. The results show that the area to be used in tumor treatment is about 20 to 25% less than expected. One plaque shows a considerable inhomogeneity with respect to dose distribution (up to 40%). A modified eye phantom was used for the determination of the central axis depth dose distribution.

Brachytherapy↗

Evaluation of the first 60 cases of poly HEMA posterior chamber lenses implanted in the sulcus.

Flexible lenses allow folding and inserting through a small incision. Using Faulkner's forceps, 60 hydrogel lenses were implanted in the sulcus through a 3.5 mm pocket incision following phacoemulsification. Mean follow-up was six months. The lens was suitable for the procedure when it was properly handled. When it was not, untimely unfolding or tears occurred, necessitating prolonged maneuvering in the eye or sometimes replacement of the lens which caused increased trauma. Though functional results were comparable to those achieved with polymethylmethacrylate lenses, all eyes achieving a visual acuity of 20/40 or better, morphological results were less satisfactory. Because of hydrogel's lack of adhesiveness and the inability to estimate the individual sulcus diameter, pseudophakodonesis was a common observation. The lens touching the posterior iris surface caused pigment dispersion (37%), sometimes leading to secondary pigment glaucoma. For this reason, we now favor capsular bag fixation.

Acrylates↗

Tissue reaction after silicone and poly(methyl methacrylate) intraocular lens implantation: a light and electron microscopy study in a rabbit model.

We describe the histopathologic results of extracapsular lens extraction and silicone and poly(methyl methacrylate) (PMMA) intraocular lens (IOL) implantation in 36 rabbit eyes. Phase-contrast microscopy was used to examine precipitates on IOL surfaces and posterior capsules. Semithin and ultrathin sections were taken from the central cornea, anterior uvea, capsular bag, and retina near the posterior pole. The follow-up was one to 16 weeks. Silicone IOLs did not cause significantly less precipitation than PMMA IOLs. Precipitates consisted of spindle-shaped fibroblast-like cells, various forms of inflammatory cells and multinucleated giant cells, single melanophages, and irregularly arranged birefringent collagen fibers. Corneal endothelial edema was slightly more prominent in PMMA IOL implanted eyes. Significant retinal edema in the posterior pole area was not observed with either of the two lens types. Severe precipitation in the form of large clusters of pigment cells and inflammatory reactions seemed to depend on mechanical trauma (iris capture and lens dislocation) and individual animal reactions, but not on the lens type used.

Animals↗

[Technic and initial results of capsule sack implantation of hydrogen lenses using a small incision].

Hydrogel lenses are flexible and hydrophilic. The IOGEL lens can be folded with Faulkner forceps and implanted through a 3.5 mm incision. Inadvertant contact with the endothelium causes only minimal cell loss. In April 1988, the authors switched from sulcus to bag fixation and have since inserted 35 lenses. Capsulorhexis appears to guarantee stability and centration. Complications are rare and minor in nature, and can be avoided by adopting an appropriate technique. While retaining all the advantages of phacoemulsification, the procedure considerably accelerates physical and visual rehabilitation. However, long-term results must be awaited.

Aged↗

Silicone oil implantation in penetrating injuries complicated by PVR. Results from 1982 to 1986.

Between 1982 and 1986, the authors implanted silicone oil in 34 eyes with retinal detachment and proliferative vitreoretinopathy (PVR) stages C-3 to D-3 caused by penetrating injuries. The retina had failed to reattach after initial vitrectomy, membrane peeling, and scleral buckling. Complete anatomic reattachment was achieved in 62%, partial reattachment in an additional 9%. Useful functional results were achieved in 68% of cases (visual acuity of 1/60 to 20/20). Postoperative complications included elevated intraocular pressure in 38% and progress of PVR with membrane formation under the silicone oil in 21% of the cases. Sixty-eight percent of the aphakic eyes developed band-shaped keratopathy. Because most of the eyes were aphakic, the authors do not report cataract incidence. In 15 eyes (44%) the silicone oil was removed. In 14 of these eyes the retina remains attached, in one eye silicone oil removal was followed by phthisis bulbi.

Eye Diseases↗

Assessment of echographic regression criteria in ruthenium-irradiated melanoma.

Steady flattening of the tumor, increasing reflectivity and decreasing vascularity are echographic signs of successful irradiation treatment. The specific example of an irradiated choroidal melanoma shows that the absence of echographic changes by no means excludes tumor destruction. Because of a dense vitreous body hemorrhage, the melanoma could only be evaluated echographically. Since the echogram lacked evidence of regression, the tumor was locally resected 5 months later. Histology, however, revealed an amorphous mass of dead tissue pervaded by intact vessels. Apparently a successfully irradiated melanoma may generate an echo typical of vital melanoma tissue. The authors therefore draw the conclusion that only a steady tumor growth, as substantiated by an echogram, may be considered an unambiguous sign of tumor vitality.

Choroid Neoplasms↗

[Comparison of the effectiveness and safety of levobunolol and timolol in ocular hypertension and chronic open-angle glaucoma].

Twenty-six patients with open-angle glaucoma or ocular hypertension were studied in a concomitant double-masked clinical trial lasting three months, in which the ocular hypotensive efficacy and safety of levobunolol (0.5%) and timolol (0.5%), topically administered twice daily, were compared. At all follow-up examinations there was a significant decrease in mean intraocular pressure from baseline in both treatment groups, with no significant difference between them in this regard. Few changes were seen in either treatment group in cup/disk ratio, visual fields, visual acuity, biomicroscopy, or ophthalmoscopy. In both groups slight decreases in mean blood pressure were observed. Levobunolol and timolol were similarly effective and safe in reducing intraocular pressure in patients with chronic open-angle glaucoma and those with ocular hypertension.

Adult↗

The triple procedure--results in cataract patients with corneal opacity.

Beginning in May 1984, we performed penetrating keratoplasties in combination with extracapsular cataract extractions and implantations of posterior chamber lenses in 21 patients. In addition to cataracts, 15 of these elderly patients presented Fuchs' dystrophy and 6 had corneal scars due to infectious or inflammatory corneal diseases. In 2 of the 21 eyes, keratoplasty was a repeat operation because of graft rejection or graft dystrophy. With a mean follow-up of 22 months, visual rehabilitation was satisfactory: 15 patients (71%) achieved a postoperative corrected visual acuity of 6/12 or better. Postoperative deviation from preoperatively calculated refractive lens power--the only major problem--remained within +/- 2 dptr in 95% (20 eyes), with an error of + 4 dptr in 1 eye (5%). In all 21 eyes, clear corneal grafts were obtained. Thus we consider the triple procedure to be the treatment of choice in cataract patients with corneas opacities.

Aged↗

Trabeculectomy and intraocular lens implantation: a combined procedure.

We present the results achieved in 26 cases of trabeculectomy combined with intraocular lens implantation after extracapsular surgery in eyes with open-angle glaucoma. Phacoemulsification was performed in nine cases, planned extracapsular cataract extraction in 17. In 23 eyes, a posterior chamber lens was implanted; in three eyes an anterior chamber lens was used because of a ruptured posterior capsule. After a follow-up period ranging from four to 29 months, the postoperative results were satisfactory in all eyes treated. The patients achieved postoperative intraocular pressure of 20 mm Hg or less. In 28% of the cases, however, additional antiglaucomatous medication is required. Given proper indications and present-day surgical techniques, this combined procedure provides effective one-time treatment for cataract and glaucoma patients as well as optimal visual rehabilitation.

Aged↗

Clinicopathologic findings after in-the-bag implantation of open-loop polymethylmethacrylate and silicone lenses in the rabbit eye.

Two lens models, one all silicone with J-loop haptics, the second with PMMA optics and angled polypropylene C-loop haptics, were implanted in the capsular bag of 36 rabbit eyes following extracapsular lens extraction. Technical ease of implantation, inflammatory response, lens position, and fibrin exudation as well as precipitate formation were examined. Biomicroscopy, light and phase-contrast microscopy were used. Differences in haptic vulnerability, lens position, and fibrin clot formation were found between the two lens types. Lens-specific differences in precipitate formation could not be substantiated.

Animals↗

Optical resolution of silicone and polymethylmethacrylate intraocular lenses.

The optical resolution and contrast of 18 silicone and 18 polymethylmethacrylate (PMMA) intraocular lenses were determined before implantation in and after removal from rabbit eyes. A specially designed microphotographic system that allows documentation and comparison of the image quality of different lens types was used. Silicone intraocular lenses showed a mean axial resolution of 1.25, PMMA lenses showed 1.60, of an optotype analogous resolution target (1.0 = 20/20) at a 3 mm pupil opening preoperatively. At one to 16 weeks postoperatively, both types of IOLs demonstrated nearly unchanged resolution. Contrast, however, decreased to between 60% and 85% of the preoperative 100% standard. This decrease was due to precipitates deposited on the lens surface, to posterior capsule opacification, and to lens decentration.

Animals↗

Evaluation of 50 silicone posterior chamber lens implantations.

This study presents our experience with 50 silicone intraocular lens (IOL) implants (STAAR Surgical Company, model AA-4004) in the posterior chamber. In the relatively short-term mean postoperative follow-up of seven months, the following complications were observed: iris chafing - pigmentary dispersion, 15 (30%); IOL tilt and decentration, 7 (14%); pseudophakodonesis, 6 (12%); fibrinous exudate, 3 (6%); luxation of one haptic in the anterior chamber, 1 (2%); IOL tears, 5 (10%). Visual acuity of 20/20 to 20/40 was obtained in 40 patients (80%). Although no severe consequences were noted, the long-term effects of the complications are unpredictable at present.

Aged↗