Structure-activity relationships in the tetrahydrocannabinol series. Modifications on the aromatic ring and it the side-chain.
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Alkylation↗
Biomedical subjects
R Mechoulam
Publications and source records attributed to R Mechoulam.
Synthesis of a potential urinary tetrahydrocannabinol metabolite.
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Animals↗
6 -hydroxy- 1 -tetrahydrocannabinol synthesis and biological activity.
6beta-Hydroxy-delta(1)-tetrahydrocannabinol, a metabolite of delta(1)-tetrahydrocannabinol has been synthesized from delta(6)-tetrahydrocannabinol. It shows high tetrahydrocannabinol-type activity in rhesus monkeys. The implications of this funding are discussed.
Animals↗
The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish.
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Cannabis↗
Identification of 5-alpha-androstane-3-alpha, 17-beta-diol as a principal metabolite of pregnenolone in rat ovary at onset of puberty.
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17-Hydroxycorticosteroids↗
Chemical basis of hashish activity.
A sample of hashish was extracted consecutively with petroleum ether, benzene, and methanol. When tested intravenously in monkeys only the petroleum-ether fraction was active. This material was further fractionated. The only active compound isolated was Delta(1)-tetrahydrocannabinol. Cannabinol, cannabidiol, cannabichromene, cannabigerol, and cannabicyclol when administered together with Delta(1)-tetrahydrocannabinol do not cause a change in the activity of the latter, under the experimental conditions used. These results provide evidence that, except for Delta(1)-tetrahydrocannabinol, no other major, psychotomimetically active compounds are present in hashish.
Animals↗
Identification through synthesis of an active delta-1(6)-tetrahydrocannabinol metabolite.
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Animals↗
Metabolism of delta 1(6)-tetrahydro--cannabinol, an active marihuana constituent.
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Cannabis↗
Synthesi of delta-1, and delta-1 (6) tetrahydrocannabinol metabolites.
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Cannabis↗
A new tetrahydrocannabinolic acid.
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Benzopyrans↗
Stereoselective cyclizations of cannabinoid 1,5 dienes.
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Alkenes↗
Stereospecific cyclizations and isomerizations of cannabichromene and related cannabinoids.
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Cannabis↗
Stereoelectronic factor in the chloranil dehydrogenation of cannabinoids. Total synthesis of dl-cannabichromene.
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Cannabis↗
Stereospecifically labeled delta1(6)-tetrahydrocannabinol.
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Cannabis↗
Hashish--13. On the nature of the Beam test.
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Cannabis↗
Hashish components. Photochemical production of cannabicyclol from cannabichromene.
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Cannabis↗
Pharmacological effects of two active constituents of marihuana.
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Analgesics↗