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Biomedical subjects

R Maynard

Publications and source records attributed to R Maynard.

33 records · Page 2Linked to original sources
PubMed1984

[Brain stem AEP in toxic comas. Correlation with brain stem reflexes].

24 deep toxic comas with respiratory assistance were studied by brain-stem reflex and BAEP. Laboratory analysis showed several simultaneous toxics (phenobarbital, benzodiazepines, tricyclic antidepressants...). Three groups of patients were defined: Twelve patients with normal BAEP and with relatively preserved brain-stem reflex (oculocephalic and oculovestibular are often disturbed but photomotor is present). Eleven patients with delayed BAEP and with more disturbed brain-stem reflex (photomotor is missing 3 times). In 2 cases (one of which is mentioned above in group B) brain-stem reflex and BAEP disappear and these patients die. Cerebral anoxia is associated here with toxics. Causes of delayed latencies (group B) are discussed (hypothermia, toxics). BAEP seems important in diagnosis and prognosis of toxic coma.

Adult↗
PubMed1983

[Seizures in the newborn infant; value of polygraphy].

Recordings were made from 20 newborns during seizures in their first days of life, using a polygraphic study enabling observation of electro-clinical seizures, electric seizures, and seizures with no EEG transfer. The interictal EEG as well as the duration of status epilepticus are discussed. An estimation of the prognosis from the EEG clinical criteria is envisaged. CT scans and ultrasound scans were performed in serious cases of neonatal distress responsible for status epilepticus; these showed diffused or localized oedema of the white matter, either isolated or associated with intracranial hemorrhagic lesions.

Electroencephalography↗
PubMed1982

A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection.

Four hundred fifty volunteers participated in a placebo-controlled, double-blind, randomized trial of the prophylactic effects of rimantadine and amantadine during an outbreak of influenza A. The subjects received drugs orally at a dose of 100 mg twice a day for six weeks. Influenza-like illness occurred in 41 per cent of the subjects receiving placebo but in only 14 per cent of those receiving rimantadine and 9 per cent of these receiving amantadine (P less than 0.001 for either drug vs. placebo). Laboratory-documented influenza occurred in 21 per cent of placebo recipients, 3 per cent of rimantadine recipients, and 2 per cent of amantadine recipients (P less than 0.001). These findings represent efficacy rates of 85 per cent for rimantadine and 91 per cent for amantadine, as compared with placebo. More recipients of amantadine (13 per cent) than recipients of rimantadine (6 per cent; P less than 0.05) or placebo (4 per cent; P less than 0.01) withdrew from the study because of central-nervous-system side effects. On the basis of this study, rimantadine appears to be the drug of choice for the prophylaxis of influenza A.

Adamantane↗
PubMed1970

[Amnesic ictus].

Explore the source record for details and available documents.

Age Factors↗
PubMedDate not supplied

[EEG and clinical study of 107 patients with acute severe traumatic comas (author's transl)].

The authors describe the EEG recordings of 107 patients with acute severe cranial trauma and signs of axial lesions. The initial EEG included: sleep patterns, alternating tracings, alpha band tracings which were either nonreactive pseudo-alpha or modulated alpha often reactive, and diffuse slow wave tracings. They found no particular tracing corresponding to a precise level of rostrocaudal destructuration, but some associations were seen more frequently. EEG sleep patterns and alternating tracings were never observed in brain stem lesions, the activity recorded being of low voltage, rigid, and non-reactive. The presence of spontaneous fluctuations (with sleep rhythms in some cases) and reactivity in other levels (mesodiencephalic junction, diencephalic and cortical-subcortical) are good prognostic signs. Focalised EEG signs are seen especially in the more rostral levels.

Brain Injuries↗