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Biomedical subjects

R Marx

Publications and source records attributed to R Marx.

At least 145 records · Page 8Linked to original sources
PubMed1975

[Hemostaseopathies in chronic, azotemic renal insufficiency. Pathogenesis, diagnosis, treatment (author's transl)].

A brief survey on the current concepts of diagnosis and pathogenesis of platelet dysfunction in chronic renal insufficiency is given on the basis of clinical hemostaseological investigations. Phenolic compounds, guanidine succinate and fibrin decomposition products are prominent in the discussion of uremia toxins possibly involved in disorders of thrombocytic function. Clinically practicable methods of analysis are briefly presented and the still imperfect status of therapy is emphasized.

Blood Coagulation Disorders↗
PubMed1975

[Stimulating effect of collagen and collagen derivatives on the propregation and adhesion of thrombocytes in defibrinogenated human citrate plasma and in animal citrate plasma].

Collagen type I form calf skin, collagen modified by pepsin, methylation, succinylation or deamidation and alpha1-chains or cyanogen bromide peptides were studied for their effect on adhesion and spreading of platelets. Some of the proteins increased platelet activity and indicated that the following structural parameters are of importance: 1. triple-helical conformation, 2. non-triple-helical regions, 3. charged amino acid side chains, 4. some activity was also detected for cyanogen bromide peptides of collagen alpha1-chain. The activity of collagen when used in a firbrinogen-free system is comparable to that of fibrinogen and potentiates platelet spreading caused by animal plasma.

Afibrinogenemia↗