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Biomedical subjects

R Martens

Publications and source records attributed to R Martens.

At least 19 recordsLinked to original sources
PubMed1990

Safety and efficacy of a thymidine kinase negative equine herpesvirus-1 vaccine in young horses.

A drug induced equine herpesvirus-1 (EHV-1) mutant lacking thymidine kinase inducing activity was developed and evaluated as a vaccine. The safety and effectiveness of the vaccine to protect against experimentally induced EHV-1 respiratory disease were evaluated in weanling horses free of EHV-1 neutralizing antibody. The vaccine was safe when administered either intramuscularly or intravenously, and EHV-1 was not shed intranasally during the 12 days following administration. Intranasal challenge with virulent EHV-1 was used to evaluate vaccine efficacy. Following challenge, there was a significantly (p less than 0.05) greater increase in peak body temperatures and duration of nasal virus shedding in the nonvaccinates, and a significant (p less than 0.05) increase in serum neutralizing antibody titers in the vaccinates.

Animals↗
PubMed1976

Degradation of [8,9,-14C]endosulfan by soil microorganisms.

Twenty-eight soil fungi, 49 soil bacteria, and 10 actinomycetes were tested as to their ability to degrade the insecticide endosulfan. Using 14C-labeled material, the qualitative as well as the quantitative formation of metabolities, as well as of 14CO2, could be followed. Sixteen fungi, 15 bacteria, and 3 actinomycetes were found capable of metabolizing more than 30% of the applied endosulfan. The major metabolities detected were endosulfate, formed by oxidation of the sulfite group, and endodiol, formed by hydrolysis of the ester bond. The majority of highly active fungi formed endosulfate as the major metabolite, whereas the majority of active bacteria formed endodiol. In addition to endosulfate and endodiol, individual cultures contained small quantities of endohydroxyether and two unidentified products. The very small quantities of 14CO2 evolved from cultures indicated that an extensive mineralization of the carbon skeleton of endosulfan did not occur.

Actinomycetales↗
PubMed1976

Competitive trait anxiety, success-failure and sex as determinants of motor performance.

Two experiments determined the effects of competitive trait anxiety, success-failure, and sex on the performance of 10- to 12 yr.-old children competing on a complex motor maze. Competitive trait anxiety was assessed by the Sport Competition Anxiety Test and success-failure was induced by giving bogus win-loss feedback. High and low competitive trait-anxiety children were randomly assigned to one of three conditions: winning 80%, 50% or 20% of 20 contests. The average completion time and the variability of times within each of two blocks of 10 contests were the two performance measures. State-anxiety was assessed with Spielberger's State Anxiety Inventory for Children as an indicant of arousal prior to and during competition. The findings of Exp. 1 yielded no significant performance differences. In Exp. 2 a significant interaction of competitive trait anxiety X success-failure X sex for performance time and variability was obtained. This interaction was largely attributed to sex differences.

Achievement↗