Search PubMed⌕ Search

Biomedical subjects

R Marquardt

Publications and source records attributed to R Marquardt.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Gelatinous tear substitutes and nonspecific eye ointments in the critical care unit and in perioperative use].

The effect of Vidisic (a new jelly artificial tear solution) and an ointment basing on Dexpanthenol on the tear production and the tear film stability was studied both on patients in the intensive care units (ICU) and during operations. In 10 relaxed and ventilated patients of the ICU there was no significant change in the tear production after application of either therapy. In 30 patients, undergoing surgery in endotracheal anaesthesia, the break-up-time and the test according to Schirmer were measured pre- and postoperatively. Like in the ICU-patients no difference in tear production could be found. Regarding the stability of the precorneal tear film however Vidisic was more effective than ointment basing on Dexpanthenol. Especially this clear jelly artificial tear solution allowed in contrast to the ointment a permanent and reliable judgement of the pupillary reaction. In addition the patients felt more comfortable with Vidisic.

Acrylates↗
PubMed1986

[Treatment of dry eye with a new gel in eyedrop form].

Vidisic, a liquid gel derived from a polymerisate of acrylic acid for the treatment of dry eyes, was tested for 3 months in an open prospective study in 55 patients with severe dry eye. Vidisic spreads well over the cornea and conjunctiva and does not cause streaks. Compared with other tear substitutes so far available, Vidisic has a much longer viability, so that no more than 3 or 4 drops a day are necessary. Also, Vidisic is better tolerated and more effective. Moreover, there was a significant improvement, both subjectively and objectively, in the patients' conditions.

Acrylates↗
PubMed1986

[Diagnostic tests in the evaluation of the tear film].

Critical appraisal of the most important testing methods for diagnosing normal and disturbed stability of the tear film meniscus. Only a carefully compiled history, a thorough inspection of the eye and several tests to determine the type and severity of the disorder can provide information about the disturbed stability of the tear film meniscus.

Biopsy↗
PubMed1986

[Corneal contact time of artificial tear solutions].

In 30 subjects without ophthalmological disease the corneal contact time of a new artificial polyacrylic-based tear gel (Vidisic, produced by Dr. Mann, Berlin) was compared with a well-known artificial polyvinyl alcohol-based tear solution. The Vidisic concentration remained in the corneal tear film 7 times longer than the substance it was compared with. In a second study including 7 normal subjects and 5 patients with keratoconjunctivitis sicca, the influence of Vidisic on break-up time (BUT) and the Schirmer test was demonstrated. It was found that tear secretion improved for 2-4 hours (Schirmer test) and the stability of the tear film (BUT) improved for about 6 hours with Vidisic. These results suggest that application of Vidisic four times a day is sufficient for efficatious therapy even in cases of severe keratoconjunctivitis sicca.

Acrylates↗
PubMed1983

Cartilage choristoma of the eye.

A young girl had a rigid, white tumor that penetrated the sclera. It was partially resected, and histopathologic study demonstrated choristoma of elastic cartilage.

Cartilage↗
PubMed1982

[The malignancy of choroidal melanomas (author's transl)].

In the destruction of choroidal melanomas with conservation of the globe two clinical parameters, the size and growth-rate of the tumor, are especially important. The malignancy can be determined from these two parameters. It is important to know that neoplasms metastasize when they are composed of more than 400 cells (10 doubling times). However, at this early stage clinical diagnosis it rarely possible. As a rule, the tumor cannot be diagnosed until it reaches a size of 5 mm (27 doubling times). Metastases must be at least 10 mm in diameter (38 doubling times) to be recognized. In the case of the fast-growing choroidal melanomas it can therefore be calculated that the formation of metastases reaches a peak after a period of three to four years, assuming that diagnosis is made as early as possible. In 64 patients followed up for five years we found that the more numerous the number of mitoses in the tissue are, the higher the mortality is and the sooner the patients die. According to our results the most important clinical parameter in the assessment of choroidal melanoma, apart from the size of the tumor, is the estimation growth-rate, as indicated by the number of mitoses.

Choroid Neoplasms↗
PubMed1980

[Studies relating to tear film stability (author's transl)].

Basic tear secretion (Schirmer test) and tear stability (fluorescein break-up time (BUT) were determined in 121 healthy subjects and related to age and goblet cell count. None of the eyes thus investigated had any inflammatory or degenerative changes of the lids, conjunctiva or cornea. A low goblet cell count was found in subjects with a short BUT but a short BUT was not uniformly correlated with a certain goblet cell count. There was no clear relation between goblet cell count and BUT or basic tear secretion. Basic tear secretion and BUT decrease continuously after the age of 50 to about half the values obtained in younger individuals. The generally held view that values of below 10 mm (Schirmer test) and below 10 s (BUT) are pathologic cannot be maintained without caution.

Adolescent↗
PubMed1980

[Radiation accidents affecting the eye and their treatment (author's transl)].

Eye injuries which can occur as a result of radiation accidents of leaks in nuclear power plants are described and their treatment discussed. The trauma may be due to mechanical or thermal influences or the result of exposure to chemicals or radioactivity. After stopping the blepharospasm careful inspection of the conjunctiva is mandatory. If the bulbus is intact, rinsing with a pulsating water jet (Waterpik) is recommended, while if it is perforated primary operative treatment of the injury must be performed before radiation damage sets in. It is pointed out that the special medical centers for the treatment of radiation damage are equipped for ophthalmic surgery.

Blepharospasm↗
PubMed1979

[Histological studies of goblet cell counts in human conjunctiva (author's transl)].

In 121 healthy subjects of all age groups the goblet cells were counted by means of conjunctival biopsies; none of these individuals showed any inflammatory or degenerative changes in their eye lids, conjunctivae or corneas. Three groups were distinguished: a small group with relatively few, a large group with an average number and a third small groups with a relatively large number of goblet cells. The number of goblet cells was usually between 26 and 40 to the square mm, but fluctuated to a great extent in all three groups. On determining age distribution, the average goblet cell counts were found to be astonishingly similar: they did not vary significantly in the different age groups. At most, one could say the goblet cell count is slightly lower from age 61 onward.

Adolescent↗