Atopic dermatitis--to be or not to be, that is the question.
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Dermatitis, Atopic↗
Biomedical subjects
R Marks
Publications and source records attributed to R Marks.
Non-melanotic skin cancer and solar keratoses in Victoria--clinical studies II.
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Adult↗
Measurement of collagen-fibre diameter in human skin.
A method for the measurement of collagen fibre diameter in human skin is described. Photographic reduction of electron micrograph negatives onto positive transparency film allows the use of a Quantimet 720 image analysis system for relatively rapid determination of mean collagen fibre diameter based upon the mean cross-sectional area of a single electron microscope field. The mean collagen fibre diameter from papillary and reticular dermis in normal skin was 56.2 +/- 2.5 nm and 62.8 +/- 4.3 nm respectively, and exhibited slightly skewed unimodal distributions.
Adult↗
The effect of povidone-iodine paint on fungal infection.
Povidone-Iodine (Betadine) Paint was used in thirteen patients with a proven fungal infection. Ten patients had pityriasis versicolor, two had trichophyton rubrum and one M. canis. In the pityriasis versicolor group, seven out of the ten patients were either improved or cleared up completely within 7 days. There were no adverse reactions in this group of patients and the material proved quite acceptable to them. Scanning electron micrographs were carried out on three of the patients and demonstrated the decrease in fungal elements after treatment and clinical improvement.
Humans↗
Inflammation due to intra-cutaneous implantation of stratum corneum.
Fragments of sterile heel callus and suspensions of human corneocytes were implanted or injected intra-cutaneously into flank skin of guinea pigs. A mixed cellular type of inflammation was produced characterized by the accumulation of polymorphonuclear leucocytes in the early stages and a more granulomatous picture in the later stages. Epithelial hypertrophy and follicular distortion with transepidermal elimination was a frequent accompaniment. Immunoglobulins and the complement component C3 were found scattered irregularly in the inflammation produced and were not thought to be important in the process. The inflammation produced closely emulated the changes observed in acne inflammation and after rupture of horn containing cysts. It is suggested that inflammation caused by the implantation of horn may be suitable for study of human skin disease in which horny debris is released into the dermis, such as acne.
Acne Vulgaris↗
Vitamin E and dapsone-induced hemolysis.
Sixteen patients, each receiving 100 mg of dapsone per day, were studied for evidence of hemolysis. Vitamin E (dl-alpha tocopherol acetate), 800 mg/day, was then administered for up to three months, and dapsone therapy was continued at the same dose. Hemolysis factors were reexamined immediately prior to cessation of vitamin E therapy. No substantial change was demonstrable for levels of hemoglobin, reticulocyte count, and haptoglobin at the end of vitamin E therapy, despite a significant rise in serum vitamin E levels. Erythrocyte survival measured in four patients before and at the end of vitamin E therapy also showed no substantial change. Erythrocyte Heinz body count, however, fell in nine of 15 patients studied, and none showed an increase in this measurement while receiving vitamin E. We conclude that in patients receiving dapsone at 100 mg/day, vitamin E therapy at 800 mg/day does not substantially ameliorate the hemolytic effect of this drug.
Adult↗
Cultured epidermal cells and burns.
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Burns↗
Acquired immune deficiency syndrome.
The first Australian case of acquired immune deficiency syndrome (AIDS), which occurred in a 27-year-old homosexual man, is reported. The patient, an American citizen now resident in Sydney, presented with life-threatening pulmonary consolidation. AIDS is characterized by severe defects in cell-mediated immunity associated with infections and neoplasms (most commonly Pneumocystis carinii pneumonia and Kaposi's sarcoma). The cause of the syndrome is unknown, but it may be a new infectious agent.
Acquired Immunodeficiency Syndrome↗
Isotretinoin and serum lipids.
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Acne Vulgaris↗
Non identity of non ionic detergent soluble (NIDS) protein and stratum corneum autoantigens.
The relationship between naturally occurring circulating stratum corneum autoantibodies and experimentally produced antibodies to a non ionic detergent soluble (NIDS) protein fraction from human stratum corneum has been investigated. Using indirect immunofluorescence and indirect haemagglutination techniques, anti NIDS protein serum was shown not to inhibit the autoantibody-antigen reaction. Furthermore no direct interaction could be demonstrated between sheep red blood cells coated with stratum corneum autoantigen and anti NIDS protein serum. The NIDS protein antigens therefore represent a separate and distinct class of stratum corneum antigens.
Antibodies↗
The distribution of precursors of glycoconjugate synthesis in human epidermis.
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Adult↗
The effects of a novel potent oral retinoid (Rol3-6298) in the treatment of multiple solar keratoses and squamous cell epithelioma.
Sixteen patients with solar keratoses and/or squamous cell carcinoma were treated for 4 weeks with Rol3-6298, a potent oral retinoid of the arotinoid series. This treatment caused a small but statistically significant reduction in the mean number and area of the lesions. Tissue measurement and cell kinetic studies demonstrated that the treatment caused significant thickening of uninvolved epidermis but no change in the rate of cell division. Similar side-effects to those occurring with etretinate were experienced.
Aged↗
Unicystic ameloblastoma.
The unicystic ameloblastoma should be considered a distinct entity and treated conservatively. The following case report emphasizes the use of computerized axial tomography in the diagnosis of this lesion. The detailed histology and conservative surgical therapy is discussed.
Aged↗
Response of human skin to ultraviolet radiation: dissociation of erythema and metabolic changes following sunscreen protection.
After UV irradiation of human skin there is an increase in epidermal and stratum corneum thickness and an increase in the thymidine autoradiographic labeling index. Previously we have demonstrated that persistent exposure to ultraviolet radiation (UVR) alters the distribution and activities of glucose-6-phosphate dehydrogenase (G-6-PDH) and succinic dehydrogenase (SDH) within the epidermis; G-6-PDH activity is increased over the whole epidermis and SDH activity is diminished in the granular cell area but increased in the basal layer. When skin is protected by an efficient sunscreen and irradiated with UVB, there is almost complete inhibition of the erythema normally seen following UVR exposure. In this study we have investigated the cytochemical, cell kinetic, and histometric changes that take place in the epidermis after UVB irradiation, with and without two different types of sunscreen. Some of the histometric and metabolic changes associated with UVB exposure were still evident despite sunscreen protection and the successful blocking of the erythema response. The implications of these findings are discussed together with the use of sunscreens to prevent development of solar damage.
Adult↗
Irritant reactions to dithranol in normal subjects and psoriatic patients.
The irritant reaction to dithranol on normal forearm skin of forty psoriatics and forty controls was investigated by skin contact thermometry and ID50 values were calculated for each skin type (I to IV). We concluded that there is no difference between the irritant effects of dithranol in psoriatics and normal subjects. There was no correlation between irritant dose threshold and minimal erythema dose (MED) to ultraviolet radiation (UVR) but skin type I patients are the most sensitive. The irritant response to dithranol can be partially blocked by prior treatment with indomethacin.
Anthracenes↗