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Biomedical subjects

R Marino

Publications and source records attributed to R Marino.

At least 73 records · Page 4Linked to original sources
PubMed1989

Cerebrospinal fluid rhinorrhea occurring in long-term bromocriptine treatment for macroprolactinomas.

Two patients harboring invasive macroprolactinomas, on treatment with bromocriptine, developed cerebrospinal fluid rhinorrhea 16 and 17 months after the beginning of the medical therapy. Neither patient had previously been submitted to surgery or radiotherapy. The fistulae were surgically corrected. Cerebrospinal fluid leakage is a well-documented complication of pituitary tumors, mainly after surgery and/or radiotherapy, but the reports of its occurrence after primary treatment with bromocriptine are rare. Therefore, the possibility of this complication must be considered, especially in patients with invasive macroprolactinomas.

Adult↗
PubMed1989

Effects of corpus callosum stimulation on the morphology and frequency of epileptic bursts in the feline topical penicillin generalized model.

Twelve cats were stimulated at the rostrum of the corpus callosum while full epileptic activity was recorded after topical application of penicillin on the cortex bilaterally. Electrocorticography was performed bilaterally. In 6 animals the electrode position was checked by evoked potentials. Stimulation parameters ranged from 0.5 to 1,000 Hz, from 2 to 10 mA, and from 0.5 to 5.0 ms. No significant modification was found in frequency, synchrony, and morphology of the epileptic bursts and spikes, suggesting that callosal stimulation, at least using this model, is ineffective in reducing epileptic activity.

Animals↗
PubMed1989

Unilateral topical cortical application of penicillin: electrographic aspects. A new complement to an old model.

In 7 cats 800 IU of penicillin were applied diffusely over one hemisphere on the exposed neocortex. After 40 min all animals showed bilateral and synchronous burst discharges with a higher amplitude at the hemisphere where the penicillin had been applied. These data fill a gap in the literature concerning feline generalized penicillin epilepsy, in which penicillin is applied bilaterally on the exposed neocortex.

Administration, Topical↗
PubMed1988

Functional microsurgical partial callosotomy in patients with secondary generalized epilepsies. I. Disruption of bilateral synchrony of spike and wave discharges.

Fourteen patients with secondary generalized epilepsy suffering from multiform seizures (MS) not amenable to medication were submitted to partial section of the corpus callosum. In all patients, there was a partial disruption of the previous generalized bilateral synchronous epileptiform discharges (GBSD). The electroencephalographic findings after callosal section are discussed with respect to their implications in furthering our understanding of the mechanisms subserving the organization of GBSD.

Adolescent↗
PubMed1988

Functional microsurgical partial callosotomy in patients with secondary generalized epilepsies. II. Mesial surface electrocorticography.

Eight patients with secondary generalized epilepsy not alleviated by medical treatment underwent partial callosotomy. During the surgical procedure, they had mesial surface ECoG recordings taken from both frontal and parietal lobes, using large flat multilead platinum electrodes, and simultaneously recordings from a number of scalp positions, using needle electrodes. In all cases studied, this approach demonstrated one or, more commonly, several focal areas of epileptiform activity discharging independently over the mesial aspects of one or both hemispheres. The findings were correlated with the pre- and postoperative EEG patterns, in the light of current concepts of generalized epilepsies.

Adolescent↗
PubMed1987

Short-term management of macroprolactinomas with a new injectable form of bromocriptine.

Three cases (2 men, 1 woman) of expansive macroprolactinoma treated with a single 50-mg intramuscular dose of a new form of injectable, long-acting bromocriptine are presented. Clinical manifestations included visual disturbances (2 cases), headache (1 case), and hypogonadism (3 cases). Laboratory tests demonstrated high basal serum prolactin (PRL) levels and evidence of involvement of other anterior pituitary hormones in all cases. Treatment was followed by marked improvement of symptoms paralleled by a sharp decrease of serum PRL levels, which normalized in 1 case. Some other anterior pituitary functions also improved. Computed tomography scan revealed shrinkage of the tumor in all cases. There were no local or serious systemic side effects. These initial findings suggest that long-acting injectable bromocriptine has a place in the initial treatment of macroprolactinomas, especially for those with neurological and/or visual manifestations. It can also be used to select patients for surgery, in the cases where clinical and radiological improvement could not be obtained. The effects of long-term use remain to be established by further studies.

Adult↗
PubMed1987

Urological manifestations of isolated iliac artery aneurysms.

Three patients with iliac artery aneurysms were seen at our institution with the chief complaints owing to urological manifestations. Iliac artery aneurysms may present with a transrectally palpable mass, hematuria, bladder outlet obstruction, ureteral obstruction, retroperitoneal fibrosis or renal failure. Any such manifestations may bring the aneurysm to the attention of a urologist before diagnosis.

Acute Kidney Injury↗
PubMed1987

Absence of suppressive effect of somatostatin on prolactin levels in patients with hyperprolactinemia.

The effect of somatostatin (SRIF: 10 micrograms/min during 120 min) on serum prolactin (PRL) levels was studied in eleven patients with hyperprolactinemia of varying causes: 2 patients with acromegaly; 2 with primary hypothyroidism; 4 with prolactinoma and 3 with drug (sulpiride) induced hyperprolactinemia. During SRIF infusion, no significant change in PRL levels was observed in any of the 4 groups studied except in one female patient with a prolactinoma. The biological activity of SRIF was demonstrated by the significant inhibition (P less than 0.05) of insulin levels seen in all 11 patients (52% fall in relation to basal) without simultaneous modification of glycemia. These data suggest that SRIF does not decrease PRL secretion in most patients with hyperprolactinemia.

Acromegaly↗
PubMed1986

K+ transport by rat colon: adaptation to a low potassium diet.

Recent studies with the isolated perfused rat kidney have demonstrated the existence of an intrinsic renal adaptation to conserve K+ in response to ingestion of a low K+ diet for 3 days. To determine whether the colon alters its K+ transport properties in a similar fashion, we measured transmural 86Rb fluxes across sheets of distal colonic epithelium under short-circuit conditions. Preliminary studies using a double-isotope technique demonstrated that 86Rb and 42K fluxes were similar; therefore 86Rb flux was considered equivalent to K+ flux. The distal half of the colon from each rat was divided into two segments, referred to as early and late distal colon. Experiments were carried out using rats fed a K+ -free, control (0.15 mmol/g), and high K+ (1.13 mmol/g) powdered diet of otherwise identical electrolyte content. Net K+ secretion (Jnet) by the early distal colon was reduced from 0.45 in the controls to -0.02 mueq X cm-2 X h-1 by a low K+ diet as a result of a decrease in serosal-to-mucosal flux (Jsm), with no change in mucosal-to-serosal flux (Jms). Conductance (GT) and short-circuit current (Isc) were unchanged. Jnet by the late distal colon averaged 0.17 in the controls and 0.01 mueq X cm-2 X h-1 with a low K+ diet, but this difference was not significant statistically. In comparison with the controls, a high K+ diet had no effect on Jnet by the early distal colon (0.48 mueq X cm-2 X h-1) but increased Jnet by the late distal colon substantially (0.77 mueq X cm-2 X h-1).(ABSTRACT TRUNCATED AT 250 WORDS)

Adaptation, Physiological↗
PubMed1986

Anterior zygomatic electrodes: a special electrode for the study of temporal lobe epilepsy.

The position of a surface electrode over the anterior zygomatic arch is described. Epileptiform activity recorded at this position is compared with that recorded by sphenoidal electrodes in 21 cases of temporal lobe epilepsy. In 100% of the cases abnormalities were detected with both electrodes, although in 11% of the cases the findings could not be definitely described as epileptiform in the anterior zygomatic electrodes.

Adolescent↗