[Hepato-gastric tuberculosis: a rare association].
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Adult↗
Biomedical subjects
R Marcos
Publications and source records attributed to R Marcos.
[Tumors of the posterior fossa in children].
INTRODUCTION: Primary tumours of the CNS form 20% of the neoplasias seen in children. They are the second commonest type of cancer seen in childhood, after leukemia. A significant proportion of paediatric cerebral tumours (> 50%) are intratentorial. OBJECTIVE: To find the frequency and clinicopathological behavior of posterior fossa tumours in children seen at our hospital. PATIENTS AND METHODS: From the hospital records, a descriptive, retrospective study was made of 112 children with tumours of the posterior fossa who were attended at the Institute of Neurology and Neurosurgery between January 1980 and December 1997. The variables: age, sex, clinical findings, site and extent of the tumour and its histological description were recorded. The mean, standard deviation, frequency distribution and chi-squared test were used, depending on the type of variable to be analyzed. RESULTS: The age of the patients when the diagnosis was made was between 8 months and 15 years (mean = 8.32 years). The male/female ratio was 59/53 (1.1/1). The commonest site of the tumours was the cerebellum (58.9%). The predominant histological types were medulloblastoma (33.92%) and astrocytoma (19.64%) in the cerebellum, glioma in the brain stem (10.71%) and ependymoma in the i.v. ventricle (8.09%). CONCLUSIONS: Endocranial hypertension and the cerebellar syndrome were the predominant clinical findings in medulloblastoma, cerebellar astrocytoma and ependymoma. In brainstem gliomas there was often involvement of several cranial nerves and long tracts.
Adolescent↗
[Pharmaceutics of pastes for polishing crowns].
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Crowns↗
Genotoxic evaluation of the herbicide paraquat in cultured human lymphocytes.
The widely used herbicide paraquat was evaluated for genotoxicity in peripheral blood human lymphocyte cultures. Sister-chromatid exchanges (SCE), chromosome aberrations (CA), and micronuclei (MN) were scored as genetic endpoints. Paraquat was administered either alone or in combination with an external source of metabolic activation. Our data indicate that paraquat induced slight but significant increases in the frequency of SCE. This genotoxic effect was not modified by cotreatments with S9 fraction from rat liver. However, paraquat did not increase the frequency of CA and MN, indicating that this bipyridylium compound is not effective in these assays, which would mean a general lack of effectiveness of the herbicide to induce clastogenic damage. In addition, cotreatments with the S9 fraction, did not modify the genotoxic ability detected in the SCE assay.
Animals↗