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Biomedical subjects

R Marcolongo

Publications and source records attributed to R Marcolongo.

At least 271 records · Page 15Linked to original sources
PubMedDate not supplied

Histopathological study of iron deposit distribution in the rheumatoid synovium.

A qualitative and semi-quantitative evaluation of synovial iron deposits in 20 patients with rheumatoid arthritis (RA) and in 12 patients presenting with degenerative and traumatic joint disease was carried out. Ferric iron deposits, abundant and preferentially distributed in the superficial and deeper connective tissue layers in the RA patients, were more limited and prevalently sited in the synovial lining layer in the controls. These results further underline the increase in synovial iron stores found in active RA and the role played by iron deposits in sustaining inflammation, as has been reported in the literature.

Adult↗
PubMedDate not supplied

Retinal vasculitis in rheumatoid arthritis: an angiographic study.

The authors studied sixty patients affected by classical or definite rheumatoid arthritis (RA), to evaluate the possible existence of retinal vasculitis, by employing fluorescein angiography. Retinal vasculitis was found in 18% of the examined patients, even if no clinical and ophthalmoscopic signs of retinal vessel inflammation were present. The authors suggest that the retina should be examined in RA patients, since retinal vasculitis may be asymptomatic at the beginning, but can represent one of the possible extra-articular manifestations of the disease.

Adult↗
PubMedDate not supplied

[Behavior of plasma and urine purines, after a purine-free diet, in normal subjects and patients with gout].

Plasma and urine oxypurines (hypoxanthine and xanthine) and uric acid, were evaluated in normal subjects and in gouty patients before and after a purine free diet. After a 7-days period, plasma oxypurines were remarkably higher in normal subjects, while they did not undergo variations in gouty patients, which showed higher in basal conditions. No significant changes in urinary excretion were observed in both cases. The interpretation of the observed variations is discussed.

Adult↗
PubMedDate not supplied

[Clearance of oxypurines and uric acid in patients with gout].

The clearance of uric acid, hypoxanthine and xanthine has been examined in gouty patients and in normal subjects comparatively to the creatinine clearance. The clearance of the three purine compounds was lower in the gouty patients, while the creatinine clearance showed a normal behavior. These results indicate that either the tubular excretion or the carriers of the considered metabolites probably undergo specific alterations in the gout.

Adult↗
PubMedDate not supplied

Antianemic and potential anti-inflammatory activity of desferrioxamine: possible usefulness in rheumatoid arthritis.

In order to study the role of excessive synovial iron sequestration in the production of anemia in rheumatoid arthritis (RA), the antianemic efficacy and anti-inflammatory effect of desferrioxamine administered in a short-term treatment (14 days), were evaluated in 10 patients suffering from classic or definite RA and hyposideremic anemia. Treatment with desferrioxamine showed an elevated urinary iron excretion, a significant increase of serum iron, UIBC and hemoglobin, and a marked progressive decrease of serum ferritin. A moderate improvement of the pain intensity, morning stiffness and Ritchie's index was also observed. The results obtained suggest that excessive reticuloendothelial iron deposits occur in RA and that the iron uptake can be an important factor in the production of anemia. Desferrioxamine seems to be useful in the treatment of patients suffering from RA and anemia, in order to release iron from synovial tissue, reduce the inflammatory process and improve anemia, changing an anemia which is typically resistant to the martial therapy into an iron-sensitive anemia.

Adult↗
PubMedDate not supplied

Gastrointestinal involvement in rheumatoid arthritis: a biopsy study.

Gastric, colonic and rectal biopsies were obtained from patients with rheumatoid arthritis. The histologic study demonstrated a greater incidence of pathological findings compared to normal subjects or in patients with gastrointestinal diseases. The histologic changes were characterized by partial or complete loss of superficial epithelium and glanmphocytes, plasma cells, granulocytes, and the presence of vasculitic lesions. These histologic findings suggest that a chronic rheumatoid inflammatory process may affect the gastrointestinal system, in keeping with the concept that rheumatoid arthritis is a systemic disease.

Adult↗