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Biomedical subjects

R Manfredi

Publications and source records attributed to R Manfredi.

At least 163 records · Page 9Linked to original sources

The treatment of AIDS-related cytomegalovirus disease with ganciclovir and foscarnet association. Three case reports.

The management of clinically resistant or relapsing cytomegalovirus (CMV) is an emerging therapeutic challenge in patients with advanced HIV infection. The efficacy and tolerability of ganciclovir-foscarnet association has been evaluated in the treatment of severe CMV disease (retinitis in two subjects, systemic disease in the remaining patient), which proved refractory to prior single drug chemotherapy in two cases out of three. A literature review of all patients receiving associated ganciclovir-foscarnet for the treatment of AIDS-related CMV disease is presented, and current perspectives of the antiviral treatment of CMV infection in the immunocompromised host are discussed.

Acquired Immunodeficiency Syndrome↗

Community-acquired pneumonia due to Staphylococcus cohnii in an HIV-infected patient: case report and review.

Coagulase-negative staphylococci recently have been implicated as a cause of serious infections in immunocompromised individuals. An unusual case of community-acquired pneumonia due to Staphylococcus cohnii in an HIV-infected drug user is described. Results of a study conducted to examine the prevalence of infection due to Staphylococcus cohnii strains and their antibiotic-sensitivity patterns show a low frequency but a high morbidity. These results and a brief review of the literature emphasize the importance of these organisms and other staphylococcal species as emerging opportunistic pathogens in patients with AIDS.

AIDS-Related Opportunistic Infections↗

Varicella in immunocompetent children in the first two years of life: role of treatment with oral acyclovir. Italian Acyclovir-Chickenpox Study Group.

An open multicenter study has been carried out to evaluate efficacy and tolerability of oral acyclovir in the treatment of varicella in immunocompetent patients in the first two years of life. Fifty-three children aged 3-24 months received acyclovir at 80 mg/Kg/day in four divided doses for 4 to 6 days; 24 of them were treated in the first 24 hours following disease onset, while the remaining 29 patients were enrolled within 48 hours. The assessment of evolution of disease signs and symptoms showed a rapid resolution of fever, itching and other constitutional symptoms, with interruption of vesicle formation and acceleration of cutaneous healing processes. No statistically significant differences have been demonstrated as to disease progression between patients treated in the first 24 hours, when compared with subjects receiving acyclovir in the following 24 hours. Acyclovir confirmed its excellent clinical and laboratory safety profile. By acting favorably on both the duration and severity of disease signs and symptoms, acyclovir treatment should be recommended in young children and infants with varicella, since a higher incidence of severe and complicated disease has been observed in these patient groups.

Acyclovir↗

Clindamycin/cefonicid in head and neck oncologic surgery: one-day prophylaxis is as effective as a three-day schedule.

The aim of our study was to evaluate the optimal duration of antibiotic prophylaxis in major oncologic surgery of the head and neck using a novel broad spectrum drug combination: clindamycin and cefonicid. A prospective randomized study was carried out on 126 evaluable patients undergoing clean-contaminated (skin to mucosa) surgery for cancer of larynx, pharynx or oral cavity. Cases at high surgical risk (because of need of pedicled or microvascular free flaps reconstruction), were excluded from the study. Within 20 days after surgery, only one case of wound infection was recorded among the 62 patients treated with the one-day schedule, versus three cases registered among the 64 subjects receiving three-day chemoprophylaxis. Episodes of systemic infections and eventual wound complications occurring in the first 20 days after surgery have also been recorded. The role of potential risk factors for postoperative complications has been evaluated. According to our findings, a three-day antibiotic regimen is not more effective than a short-term (one-day) schedule in preventing wound or systemic infection in clean-contaminated head and neck cancer surgery without flap reconstruction.

Adult↗

Progressive intractable actinomycosis in patients with AIDS.

Two rare cases of progressive oropharyngeal actinomycosis, characterized by a subacute and invasive course despite seemingly appropriate antibiotic and surgical treatment, have been observed in patients with AIDS. A brief review of previously reported cases of actinomycosis in HIV-infected patients is presented. Clinical, diagnostic and therapeutic problems dealing with actinomycosis in the immunocompromised host are discussed.

AIDS-Related Opportunistic Infections↗

[The tissue characterization of focal liver lesions with magnetic resonance imaging].

This study was aimed at assessing the accuracy of Magnetic Resonance Imaging (MRI) in the characterization of focal liver masses. We prospectively examined 51 patients with focal liver masses: the morphological features were investigated with different pulse sequences and the functional characteristics were studied after the i.v. administration of Gd-DTPA (2 mmol/kg). MR findings were compared with those of gold standard methods, i.e., percutaneous biopsy, surgery or, for hemangiomas, 99mTc-labelled blood cell liver scintigraphy. All hemangiomas presented with typical features: signal intensity was very high on long TE images (> 140 msec) and a globular enhancement pattern, with centripetal progression, was observed after dynamic studies. This signal pattern on T2-weighted images is highly indicative of hemangioma. Five of 7 focal nodular hyperplasias (71%) were isointense with hepatic parenchyma on all pulse sequences; the central scar was observed in 5/7 cases on short TR/TE images and in all cases on long TR/TE images in 16/17 cases (94%). High signal intensity on T1-weighted images was statistically significant for HCC. A pseudocapsule was observed in 12 cases (70%). A mosaic pattern on T2-weighted images was observed in 3 cases. Seventy-four per cent of HCCs exhibited signal enhancement during the arterial phase of the dynamic study. Metastases presented a uniform pattern, i.e., they were hypointense on T1-weighted and hyperintense on T2-weighted images in 12/13 cases (92%). A central hypointense area on T2-weighted images is indicative of coagulative necrosis. A lesion with these morphological features and hypovascular signal is suggestive of metastasis.

Biopsy, Needle↗

[Congenital anomalies of the inferior vena cava: role of imaging].

In recent years, clinics and radiology of congenital anomalies of the inferior vena cava have increased in importance in planning abdominal surgery, liver or kidney transplantation, or new interventional or diagnostic procedures such as the positioning of inferior vena cava filters to prevent pulmonary embolism, varicocel sclerotherapy and renal venous sampling. In the past, the radiologic assessment of these rare anomalies was performed only with angiography, which remains the most accurate diagnostic method. Today, besides angiography, less invasive examinations can be performed, e.g., US, CT and MRI, with MRA. In the last two years, 5 patients with inferior vena cava anomalies were examined: 3 had double inferior vena cava and 2 azygos continuation. All of them were submitted to US, CT, MRI and MRA and 3 patients underwent also angiography, two of them with double puncture. US can suggest the diagnosis but may be limited by technical factors and in the assessment of the whole inferior vena cava. Enhanced CT can depict anomaly extent, but uses contrast agents and ionizing radiations. Angiography better depicts craniocaudal spread and collateral networks but is an invasive procedure and sometimes needs a double puncture (double inferior vena cava). MRI, with MRA, yields the same information as the other modalities, but without contrast agents or ionizing radiations. The development of velocity encoded sequences will probably make this technique the method of choice in the study of inferior vena cava anomalies. Our study was aimed at reviewing the embryo-genesis of inferior vena cava anomalies and to assess the relative importance of different diagnostic procedures in the diagnosis and staging of these anomalies.

Aged↗

Histoplasmosis capsulati and duboisii in Europe: the impact of the HIV pandemic, travel and immigration.

The present report describes a fatal case of imported AIDS-related disseminated histoplasmosis capsulati infection associated with multiple coexisting infections, diagnosed with cultural recovery of Histoplasma capsulatum var. capsulatum with a commercial radiometric Mycobacterium medium. The epidemiological and clinical features of histoplasmosis capsulati and duboisii in Europe are reviewed by examining also 69 documented cases of Histoplasma capsulatum var. capsulatum infection (25 in AIDS patients) and 17 cases of Histoplasma capsulatum var. duboisii infection (3 in HIV-infected patients), described since 1980. This draws special attention to the role played during recent years by the emergence of the HIV pandemic and the progressive intensification of travel and immigration as risk factors for this disease in our continent. AIDS patients, who are prone to multiple concurrent opportunistic infections which may share clinical and laboratory features with each other and with other HIV-associated diseases, represent the most relevant current group at risk for severe disseminated histoplasmosis, which may come to medical attention far from their place of origin.

AIDS-Related Opportunistic Infections↗

Self-reported use of drugs for sleep or distress among French adolescents.

PURPOSE: In the framework of an epidemiological survey on adolescent health, we investigated teenagers' psychotropic drug use to identify risk factors. METHODS: A representative sample of school adolescents aged 12-20 years (N = 3287) was asked to fill out a self-administered questionnaire on their current health status (depressive mood, somatic complaints) and their psychotropic drug use. Parents completed a second questionnaire about the subjects' childhood. RESULTS: About one in five (21.1%) indicated having used psychotropic medications during the previous 12 months, most of which were prescription drugs. Drugs for tension or distress were taken more frequently than ones for sleep disorders. Psychotropic drug use was more widespread among girls (27.5%) than among boys (13.8%), and it increased with age: at 18 years 27.9% of the teenagers (versus 12.7% at age 12-13 years) had used psychotropic medicine. Adolescent psychotropic drug use was related to current depressive mood or somatic complaints, and to consumption of psychotropic drugs during childhood. A logistic regression analysis showed that current depression and past psychotropic use between the ages of 6-12 years were the major associated factors of adolescent consumption. CONCLUSIONS: The hypothesis of psychotropic drug use as an early "learned" response to psychological problems is discussed.

Adolescent↗

Clinical diagnoses in 216 insomnia patients using the International Classification of Sleep Disorders (ICSD), DSM-IV and ICD-10 categories: a report from the APA/NIMH DSM-IV Field Trial.

Three diagnostic classifications for sleep disorders have been developed recently: the International Classification of Sleep Disorders (ICSD), the Diagnostic and Statistical Manual, 4th edition (DSM-IV), and the International Classification of Diseases, 10th edition (ICD-10). No data have yet been published regarding the frequency of specific diagnoses within these systems or how the diagnostic systems relate to each other. To address these issues, we examined clinical sleep disorder diagnoses (without polysomnography) in 257 patients (216 insomnia patients and 41 medical/psychiatric patients) evaluated at five sleep centers. A sleep specialist interviewed each patient and assigned clinical diagnoses using ICSD, DSM-IV and ICD-10 classifications. "Sleep disorder associated with mood disorder" was the most frequent ICSD primary diagnosis (32.3% of cases), followed by "Psychophysiological insomnia" (12.5% of cases). The most frequent DSM-IV primary diagnoses were "Insomnia related to another mental disorder" (44% of cases) and "Primary insomnia" (20.2% of cases), and the most frequent ICD-10 diagnoses were "Insomnia due to emotional causes" (61.9% of cases) and "Insomnia of organic origin" (8.9% of cases). When primary and secondary diagnoses were considered, insomnia related to psychiatric disorders was diagnosed in over 75% of patients. The more narrowly defined ICSD diagnoses nested logically within the broader DSM-IV and ICD-10 categories. We found substantial site-related differences in diagnostic patterns. These results confirm the importance of psychiatric and behavioral factors in clinicians' assessments of insomnia patients across all three diagnostic systems. ICSD and DSM-IV sleep disorder diagnoses have similar patterns of use by experienced clinicians.

Adolescent↗

Vasoactive intestinal polypeptide (VIP) secretion and refractory diarrhea in patients with AIDS or AIDS-related complex (ARC).

Elevated plasma levels of vasoactive intestinal polypeptide (VIP) (as assessed by a radio-immunoassay), were found in 7/11 patients with AIDS or AIDS-related Complex (ARC), evaluated because of prolonged intractable diarrhea with either an infectious (6 cases) or a non-infectious (5 cases) etiology. Six subjects have been treated with the somatostatin analogue octreotide, which gave both a favourable clinical response and a significant reduction in plasma VIP concentrations. Evaluation of plasma VIP levels may provide a pathophysiological basis for explaining the efficacy of octreotide therapy in HIV-infected patients suffering from both infectious and non-infectious refractory diarrhea.

AIDS-Related Complex↗

[Bell's palsy in HIV infection].

Neurological complications represent one of the most important causes of morbidity and mortality in patients with HIV infection or AIDS. The peripheral nervous system is frequently involved in different stages of HIV disease, and the etiopathogenetic mechanisms are various. Idiopathic peripheral facial nerve palsy (Bell's palsy) has been considered by several Authors as one of the possible neurologic complications of HIV infection, mainly described in the early stages. As a matter of fact when facial palsy onsets in the late stages of the disease, when there is a severe immunodeficiency, usually is secondary to opportunistic infections, polyradiculopathy, or tumors involving the nervous system. To our knowledge, in the current literature there are few clinical studies reporting facial palsy associated to HIV infection. Since 1986 till 1992 three HIV infected patients with Bell's palsy have come to our observation. All three of them were asymptomatic (CDC II) and in one of them was the first clinical manifestation indicating HIV infection. The palsy in this patient and those reported by others was self-limiting with a good prognosis.

Adult↗

Associated factors for self-reported binge eating among male and female adolescents.

As part of an epidemiological study, adolescents aged 12-19 (n = 3287) filled out a self-administered questionnaire concerning their eating behaviours. The analysis showed that binge eaters (BE) had disorderly eating habits (skipping meals, snacking, eating sweets, unbalanced diets), concern with body shape (feeling too fat) and depressive symptoms more often than non binge-eaters (NBE) did. This relationship between binging episodes on the one hand, and eating habits, concern with body shape, and depressiveness on the other, has been observed for both sexes, in separate logistic regression analyses.

Body Image↗