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Biomedical subjects

R Maier

Publications and source records attributed to R Maier.

162 records · Page 9Linked to original sources
PubMedDate not supplied

Stress effects on hormonal growth factors in tobacco tissues indicated by special changes in the isoelectric peroxidase patterns.

The isoelectric peroxidase patterns of tobacco tissue cultures allow us to draw inferences to cell elongation and cell division because certain zones in acid pH ranges respond to the influence of auxines and gibberellins (promoting cell elongation) and others respond to the influence of cytokinins (promoting cell division). Stress, due to the absence of phosphate and presence of lead in the medium, causes characteristic changes in the intensity of these sensitive zones in peroxidase patterns. It may be deduced that the increase and decrease of these zones correspond to stimulation and inhibition of cell elongation and cell division, respectively. Cell elongation remains almost unaltered by lack of phosphate but is markedly inhibited by lead, while cell division is enhanced. However, stress brings about a reduction of dry weight. Reactions to stress can be observed earlier in patterns of peroxidase than in growth.

Cell Division↗
PubMedDate not supplied

Long-term results of pedicle stabilized thoracolumbar fractures in relation to the neurological deficit.

88 patients with thoracolumbar fractures and short-segment (mono or two segment) pedicle instrumentation from the years 1985-92 had a follow-up examination after an average time of 5.6 years. The 56 men and 32 women had an average age of 32.6 years at the time of injury, 24 patients primarily had a complete and 43 patients an incomplete paraplegia, 21 patients showed no neurological deficits. The operative decompression of the spinal cord and stabilization of the injured spine by short segment pedicle instrumentation led to a complete or partial remission of the neurological deficits in 93% of the patients with incomplete paraplegia. Operative stabilization allowed an early mobilization and rehabilitation of these patients. We found no tendency to an increased complication rate in patients with neurological deficits compared to patients without neurological deficits. Patients with initially incomplete paraplegia complained more often about pain than all the other patients. Despite intensive rehabilitation and retraining programs handicapped patients had obvious disadvantages regarding their further careers.

Adult↗
PubMedDate not supplied

Viscosupplementation with hylan G-F 20: a 26-week controlled trial of efficacy and safety in the osteoarthritic knee.

Hylan G-F 20, which is derived from hyaluronan, is a highly purified, elastoviscous fluid with rheologic properties similar to those of synovial fluid in the knee joints of healthy young persons. The efficacy and safety of viscosupplementation with hylan G-F 20 were evaluated in a multicenter, double-masked clinical study in patients with chronic idiopathic osteoarthritis (OA) of the knee of 1 to 30 years' duration. Three intra-articular injections of 2 mL hylan G-F 20 were administered 1 week apart to 57 knees. The control group (60 knees) received 2 mL of physiologic buffered saline solution at the same intervals. Patients were predominantly female (65%), with a mean age of 62 years and mean weight of 76 kg. Using a visual analogue scale, patients assessed the following clinical variables: pain during weight-bearing, pain at rest during the night, reduction of pain during the most painful movement of the knee, and treatment success. Evaluators also assessed patients' loss of activity while performing difficult daily tasks and treatment success. There was dramatic early improvement in all six variables with hylan G-F 20 beginning after the first injection; the improvement continued through the study end points. The differences between hylan G-F 20 and saline treatment were statistically significant for all outcome measures. In the hylan G-F 20 group, 39% to 56% of patients were free or nearly free of weight-bearing pain 10 to 24 weeks after the last injection. Treatment with saline was less effective, with fewer than 13% of patients free or nearly free of weight-bearing pain. Use of rescue therapy was significantly greater in the saline group than in the hylan G-F 20 group. No adverse events were observed in the injected joint after hylan G-F 20 treatment. These results demonstrate that hylan G-F 20 is effective and well tolerated in the management of chronic idiopathic OA.

Adult↗
PubMedDate not supplied

[Is CNS activity modified by pulsed electromagnetic fields?].

In the present pilot study we examined the effects of electromagnetic fields on the biological organism. The study was prompted by discussions on the possible effects on the nervous system and cognitive processes of fields produced by mobile phones. The experiments were performed in an electrophysiological laboratory. Eleven volunteers were exposed to pulsed electromagnetic fields (GSM standard). The psychophysiological method of assessing the order threshold (Ordnungsschwelle = OS) was used to examine cognitive performance. Under the test conditions, nine of the subjects showed a loss of mental regeneration, as reflected by an increase in the OS, in comparison with the field-free situation. The results of our experiments suggest an influence of pulsed fields on the cognitive regeneration process.

Adult↗