Boronated antibodies for neutron capture therapy.
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Biomedical subjects
Publications and source records attributed to R Müller.
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Ten gravidae with normal course of pregnancy in the third trimester underwent a bicycle stress test (semi-supine, 75 W, 3 min). By means of pulsed Doppler sonography, a lowering of the resistance index (RI) in the maternal femoral artery from 93% to 69% was ascertained, though also a rise in maximum systolic velocity (VMAX (syst)) from 73 cm/sec to 194 cm/sec, in maximum diastolic velocity (VMAX diast)) from 5 cm/sec to 61 cm/sec, and in the time-averaged maximum velocity (TAVMAX) from 20 cm/sec to 101 cm/sec. These changes are statistically significant. In the maternal common carotid artery these parameters remained stable or changed little, for example VMAX (diast), which dropped from 24 cm/sec before to 19 cm/sec after exercise, and the RI, which rose from 77% to 84%. Neither in the uteroplacental vessels nor in the umbilical artery were any changes in the RI found (40% to 42% and 58% to 57%, respectively). The fetal cardiotachograms were normal in all cases, while not all cases manifested a rise in fetal heart rate following maternal stress. These results indicate that uteroplacental perfusion and the umbilical circulation remain constant. Doppler sonography thus demonstrates directly and noninvasively that provided placental function is normal the uteroplacental and fetoplacental circulation are not influenced by moderate physical exertion.
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Sound level, electrocardiogram, electromyogram, skin conductance, and respiration were recorded under field conditions in 33 airport area residents. During the rcordings, the subjects had to perform different activities (e.g., filling out forms, concentration test, noise assessment, relaxation, and direct conversation with the experimenter). The different activities caused significant shifts in clusters of physiological data in all subjects. Aircraft noise and incidental background noise caused such shifts in the majority of subjects. Subsequent correlational and cluster analysis for the effects of sound intensity revealed interactions with the type of ongoing activity. Vegetative noise responsiveness was not correlated with noise exposure level and subjective complaint behavior, but was correlated with vegetative responsiveness to the different ongoing activities.
In Germany, a sick employee usually continues to get his wages from his employer for six weeks either in full or reduced. After that period, he only receives "sick benefit payments" (so-called Krankengeld) from the statutory bodies, which, up to 31 December 1996, amounted to 80% of his original gross wage earnings. This has been cut down to 70% of the gross wage earnings effective 1 January 1997. The purpose of this study was to assess the consequences of this general cutdown of sick benefits. A standardised questionnaire was posted to a total of 7,036 female recipients of sick benefit who were members of a South German statutory health insurance body and who resided in various parts of Germany (membership as on 17 December 1996). 2,416 completed questionnaires were returned by 19 February 1997 (= 34.9%). The average daily sick benefit payment dropped from DM 91.95 in December 1996 to DM 82.39 in January 1997, which is equivalent to a sick benefit payment reduction by 10.4 per cent. The average extra cost caused by the illness and not covered by sick benefit amounted to DM 152 per month; one-quarter of the questioned patients were even compelled to pay DM 200 per month extra from their own pocket. Sick benefit recipients must accept a very substantial real monthly income loss. The average income of an employee who is ill for more than 6 weeks is more than a quarter below that of a healthy employee. 78.5% of the questioned persons rated the financial burden and privations caused by the sick benefit cutdown as "extremely heavy" or "considerable". It became evident that the majority of the female patients receiving sick benefit were chronically ill (62.6%). The most frequently reported diseases were diseases of the spine (30.3%) and joints (16.3%), injuries and accidents (14%) and psychiatric illnesses (8.5%). The results of the survey show that the political motive underlying the attempted modification of illness behaviour by means of economic incentives to be healthy, is far removed from reality, for the cutdown of sickness benefit severely affects a group of gainfully employed persons who are in the midst of a deep existential crisis and sorely in need of extensive physical and mental support. From the sociomedical aspect the sick benefit cutdown is highly problematical as far as this group of persons is concerned, since recovery and cure are impeded by measures that lower the status and are experienced as punitive.