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Biomedical subjects

R M Zuker

Publications and source records attributed to R M Zuker.

At least 73 records · Page 4Linked to original sources

Intra-abdominal tissue expansion: an adjunct in the separation of conjoined twins.

Intra-abdominal tissue expansion routinely occurs physiologically with pregnancy and may be seen in a variety of pathologic states. There are a number of situations where additional abdominal wall would be helpful. We encountered such a situation in a set of ischiopagus conjoined twins. In effect, separation would result in an abdominal wall deficit of approximately 50%. As an alternative to intraperitoneal air, we inserted two 1,000 mL tissue expanders through a subcostal incision at 6 months of age. Over the ensuing 7 weeks, each expander was gradually inflated to greater than capacity (1,250 mL each). Except for initial ileus, there was no difficulty in expanding the abdomen to enormous proportions. At the time of surgical separation, the expanders were removed and the available abdominal wall tissue almost closed directly on both children. Closure was complete in one baby, whereas a small upper abdominal wall defect was left in the other, necessitating Marlex reinforcement. There has been a recent explosion in the use of tissue expanders in reconstructive surgery. From head to toe, soft tissue can be expanded to be used as flaps, to close donor defects, or both. With this report, its use intra-abdominally is described. Future application is limited only by our ingenuity and imagination.

Abdominal Muscles↗

The dorsalis pedis free flap: technique of elevation, foot closure, and flap application.

The dorsalis pedis free flap is an excellent reconstructive tool for thin remote mucosal defects, for heel and hand defects where innervation is critical, and as an osteocutaneous flap with unique application to mandibular and floor of mouth reconstruction. The major criticism with this flap is related to its uncertain vascularity and the donor defect. We have found in our series of 45 cases that the vascular anatomy is exceedingly reliable. Problems with the donor defects are all related to technique. With care in flap elevation and foot closure, which we describe in detail, an acceptable donor site with minimal complications can be achieved. The clinical applications of this flap are illustrated by three case reports. Our experience with the donor site has not been problem-free. However, we do believe that with meticulous technique primary healing will occur without functional disability and with minimal cosmetic deformity.

Accidents, Occupational↗

Functional, mechanical, and biochemical assessment of ultrasound therapy on tendon healing in the chicken toe.

We studied the therapeutic effect of ultrasound treatment on the functional recovery of surgically repaired profundus tendon in the right third toe of mature White Leghorn hens. Ultrasound treatment was given daily for 5 minutes for a total of 20 treatment days, starting immediately after 4 weeks immobilization. Ultrasound (frequency 3.0 mHz; intensity 0.75 W/cm2) was delivered to the right leg by a 5-cm2 probe through distilled water in a bath kept at 35 degrees C. The flexion of the toe was measured preoperatively for 4 consecutive days and daily for 6 weeks after the start of ultrasound treatment for the calculation of percent of functional recovery of the flexor tendon. The non-ultrasound-treated group of birds went through the same manipulations except that no ultrasound was given when the right leg was immersed in the water bath. Ultrasound treatment significantly (p less than 0.01) improved the functional recovery of the repaired tendons (less than 5-mm gap) starting on the third week of treatment (94 +/- 2 percent) compared with the non-ultrasound-treated group (79 +/- 4 percent). Ultrasound treatment had no effect on gap formation or breaking (tensile) strength of the repaired tendons. It is concluded that ultrasound enhanced functional return of repaired flexor tendons in the hen, and the clinical implication is discussed.

Animals↗

Application of microvascular free osteocutaneous flaps in the management of post-radiation recurrent oral cancer.

Fifty-nine patients underwent free flap osteocutaneous reconstruction that consisted of flaps of the dorsum of the foot in 26 patients and iliac crest flaps in 33 with a success rate of 92 percent and a mortality rate of 1.6 percent. These flaps, which require the expertise of microvascular surgeons, are time-consuming and complicate operating room and time management, but they represent a remarkable advance in reconstruction that can facilitate cosmetic and functional recovery of the patient. In particular, they promote healing in radiation-recurrent oral cancer and represent a definitive form of management for established radionecrosis of the mandible. The large volume of tissue available with iliac crest osteocutaneous grafts permits the management of patients with extensive cancer involving the skin, mucosa, and bone, but cancer control may still be disappointing and there is a need for improved adjuvant chemotherapy protocols. This technique appears to be a dependable, repeatable, and significant advance in management of the patient with head and neck cancer.

Adult↗

Resurfacing weight bearing areas of the heel. The role of the dorsalis pedis innervated free tissue transfer.

Five cases of chronic ulceration following skin graft resurfacing of the weight bearing surface of the heel are presented. All were managed with debridement and coverage with a free innervated dorsalis pedis tissue transfer. The technical refinements that have contributed to the reliability of the flap include careful distal identification of the first dorsal metatarsal artery (FDMA) and division of the dorsalis pedis artery (DPA) under direct vision below the takeoff of the FDMA. Donor site morbidity has been minimized by taking care to preserve the extensor paratenon as a bed for the subsequent skin graft and by immobilization of the donor foot with plaster and bed rest for 10 days. Four of the patients were followed for 2, 4, 4, and 6 years; one was lost to follow-up. All were active with protective sensation in their flaps. No instances of flap breakdown and no significant donor site morbidity were noted. The dorsalis pedis innervated free tissue transfer is recommended as a reliable procedure for resurfacing weight bearing areas of the foot when simpler methods have failed.

Adolescent↗

Effect of glucocorticoid treatment on skin capillary blood flow and viability in cutaneous and myocutaneous flaps in the pig.

The effect of methylprednisolone treatment on skin-flap viability and capillary blood flow was studied in a series of four experiments. Intramuscular methylprednisolone injections (30 mg/kg per day), given in single or divided doses preoperatively or postoperatively, had no effect in augmenting skin viability in arterialized cutaneous, myocutaneous, or random skin flaps compared with the control. Capillary blood flow was studied in arterial buttock flaps and latissimus dorsi myocutaneous flaps raised on animals treated preoperatively with methylprednisolone or saline (control), and no significant difference in capillary blood flow was noted between the treatment and control flaps. It was concluded that methylprednisolone has no significant therapeutic effect either in increasing flap viability or in increasing capillary blood flow in skin flaps in pigs.

Animals↗

Mandibular reconstruction in the radiated patient: the role of osteocutaneous free tissue transfers.

This paper discusses our experience with the second metatarsal and iliac crest osteocutaneous transfers for mandibular reconstruction. The prime indication for this type of reconstruction was for anterior mandibular defects when the patient had been previously resected. Midbody to midbody defects were reconstructed with the metatarsal and larger defects with the iliac crest. In most cases, an osteotomy was done to create a mental angle. The evaluation of speech, oral continence, and swallowing revealed good results in all patients unless lip or tongue resection compromised function. Facial contour was excellent in metatarsal reconstructions. The iliac crest cutaneous flap provided a generous supply of skin for both intraoral reconstruction and external skin coverage but tended to be bulky, particularly when used in the submental area. Thirty three of 36 flaps survived completely. Flap losses were due to anastomosis thrombosis (1), pedicle compression (1), and pedicle destruction during exploration for suspected carotid blowout (1). Ninety three percent of bone junctions developed a solid bony union despite the mandible having had a full therapeutic dose of preoperative radiation. Despite wound infections in 8 patients, and intraoral dehiscence with bone exposure in 12 patients, all but one of these transfers went on to good bony union without infection in the bone graft.

Adolescent↗

Functioning free muscle transplantation.

Functioning free muscle transplantation to the extremity is technically feasible based on microvascular anastomosis and fascicular nerve repair. Success depends on precise operative technique and a vigorous program of postoperative therapy. The most important operative details are the nerve repair and placement of the muscle at optimum tension. The forearm should be considered for muscle transplantation if there is a lack of finger flexion as a result of the loss of flexor musculature and if simpler techniques of tendon transfer are unavailable. The long-term results of 12 muscle transplantations to the forearm are presented. Eleven muscles survived completely and provided useful function, Nine provided a full range of finger motion. The maximum grip strength obtained with this procedure was 50% of normal grip strength.

Adolescent↗

Facial contour reconstruction with free flaps.

Augmentation of facial soft tissues is frequently required in Romberg's disease, lateral facial dysplasia, lipodystrophy, and following tumor resections. The buried deepithelialized free groin flap provides a satisfactory solution to this problem. Technical refinements have ensured the survival of the flap and the sophistication of the contour correction. These refinements are a careful analysis of the defect, appropriate contouring prior to revascularization of the flap, slight over-correction of the eyelid defect, and a submandibular incision for improved exposure. The groin flap provides the soft, natural reconstruction desired by the patient. All patients with Romberg's disease maintained the bulk of their reconstructions.

Adult↗

Muscle transplantation by fascicular territory.

In some muscles, distinct and separate portions of the muscle are each under the control of a different fascicle of the motor nerve. Although there is some slight overlap in areas, this unit, a single fascicle muscle territory, is present in the gracilis muscle. Microneurovascular techniques have improved the reliability of muscle transplantation for the reconstruction of facial paralysis. The amount of movement obtained depends on many factors, including the amount of muscle transplanted and the adequacy of its reinnervation. The ability to transplant a small segment of a muscle based on the fascicular territory enables the surgeon to supply the amount of movement that each individual patient requires.

Adult↗

The temporary stent technique: an easier method of micro-venous anastomosis.

The microvascular repair of small veins is technically difficult. A new method using a temporary "stent" has been studied experimentally in microvenous anastomoses of the femoral veins in twenty-four rats. The technique is described in detail. The results were evaluated by gross observation and by histological section. Improved patency rates were demonstrated and the advantages of the technique are discussed. The technique could be very useful in the anastomoses of small, fragile veins, particularly by the less experienced microsurgeon.

Animals↗

A rapid and effective method of skin graft stabilization in burned children.

A rapid and effective method of securing multiple skin grafts to burned children is described. It entails stapling an elastic net over grafts that have been backed onto Sofratulle. The staples pierce normal or healed tissue on the periphery of the wound, thus avoiding hemorrhage. The two-way stretch of the net prevents shearing during movement yet facilitates access for adjustment and routine graft care. Skin grafts are held against their bed with firm, even pressure. This method is not only easier and more rapid than direct stapling methods but offers a better prospect of a complete take.

Bandages↗

Survival of a free flap after 20 hours of immediate post-operative venous occlusion.

A case report illustrating survival of a free flap after 20 hours of immediate post-operative venous occlusion is presented. This represents the most dramatic salvage of a free flap in the authors experience. It suggests that the late diagnosis of venous obstruction may not preclude satisfactory reexploration and repair of a thrombosed vein. Nevertheless, it is the authors' opinion that the shorter the interval of venous obstruction the more satisfactory will be revision of the anastomosis.

Adult↗

Microvascular free flaps in head and neck reconstruction.

Microvascular free tissue transfer can be applied to head and neck reconstruction where: (a) conventional flaps have been used successfully, (b) conventional flaps are extremely difficult to use and such procedures are undertaken with reservation and (c) conventional flaps cannot accomplish the reconstructive goal. The authors describe examples of these applications and summarize their experience in their first 10 cases. All flaps survived completely; there were four minor complications. Reconstruction with microvascular free flaps has many advantages over conventional techniques. The flap tissue retains its vascularity-important in irradiated tissue-there are no open wounds and this single-stage procedure is associated with a high rate of flap survival. Specifically, the flap can be oriented with ease, without restriction caused by a tight pedicle. The donor sites are less conspicuous and previous use of conventional donor sites is not important. Most importantly compound skin and bone flaps can be used simultaneously to reconstruct mandibular and lining defects. This application is not possible wtih techniques other than free flap transfer.

Carcinoma, Squamous Cell↗

Head and neck reconstruction following resection of carcinoma, using microvascular free flaps.

Our experience with 15 microvascular free-flap transfers is documented and discussed. We feel that the procedure is an effective means of reconstruction for complex and extensive defects. Rapid advances have been made in all areas of cancer surgery. It is important that these patients be afforded a speedy and, preferably, immediate reconstruction and rehabilitation. Conventional techniques do not satisfy all the required goals.

Aged↗

Use of microvascular flaps including free osteocutaneous flaps in reconstruction after composite resection for radiation-recurrent oral cancer.

Fourteen patients underwent microsurgical free flap procedures for reconstruction after composite resection of radiation-recurrent oral cancer. The use of attached metatarsal bone in nine patients for mandibular reconstruction is in our view a significant advance in this field. Two failures occurred, one due to sepsis and one to delayed thrombosis. Our experience indicates that this procedure deserves a place in the surgical treatment of patients afflicted with oral malignancy.

Adult↗