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Biomedical subjects

R M Winston

Publications and source records attributed to R M Winston.

152 records · Page 9Linked to original sources
PubMed1965

Phycomycosis of the bronchus.

A case of phycomycosis of the bronchus in a 29-year-old diabetic man is reported. The interval between infection and death was not less than 35 days. Infection of the bronchus appears to have been direct. The diagnosis of phycomycosis could have been made before death.

Adult↗
PubMedDate not supplied

Fertility after salpingostomy following mechanically produced hydrosalpinx in rabbits.

Microsurgical salpingostomy results in 90% of tubes remaining patent following surgery. Although pregnancy rates have improved to a slight extent, the percentage of patients having live babies after salpingostomy is still disappointing. The discrepancy between patency rates and pregnancy rates seems to be due mainly to long standing tubal damage after the original infection. Possibly, raised intraluminal pressure from accumulated fluid may be a factor. Mechanically produced hydrosalpinges in rabbits show similar morphological characteristics to human hydrosalpinges (Vasquez et al., 1981, Otubu et al., 1984). This rabbit model was used in this study to examine the relationship between the severity of these changes and fertility after salpingostomy. Mechanical hydrosalpinges were produced in thirty mature New Zealand white rabbits by double clip application. After a period varying from 8 to 52 weeks of clip application, cuff salpingostomy and ampullary-isthmic anastomosis was done. One week after surgery, the animals were mated with bucks of proven fertility. There were pregnancies in all the uterine horns on the unoperated side (control) in all animals. There were pregnancies on the operated side in only two animals giving a pregnancy rate of 6.7%. A total of sixteen tubes were patent out of thirty operated, giving a patency rate of 53.3%. Adhesion was a major problem. We conclude that fertility is reduced after salpingostomy in mechanically produced hydrosalpinges in rabbits. The significance of this finding is discussed.

Animals↗
PubMedDate not supplied

Ovarian function after salpingostomy following mechanically produced hydrosalpinx in rabbits.

The discrepancy between pregnancy and patency rates after salpingostomy is explained largely by the residual functional damage to both the mucosa and smooth muscles of the fallopian tube. The function of the ovary after salpingostomy has not been extensively studied. Hydrosalpinx was mechanically induced by double clip application in thirty adult female New Zealand white rabbits. After varying periods of hydrosalpinx formation, ampullary-isthmic anastomosis and cuff-salpingostomy were carried out using full microsurgical techniques. The animals were mated 1 week after surgery. Ten days after mating, laparotomy was performed. The contralateral oviducts and oviducts from unoperated animals served as controls 1 and 2 respectively. Corpora lutea counts and ovarian venous estradiol 17B (E2) and progesterone (P) levels were measured to assess ovarian function. The mean values (+/- s.e.) for corpora lutea count on Control 1, Control 2 and operated sides were 6.46 +/- 0.43, 5.69 +/- 0.44 and 4.03 +/- 0.32 respectively. The mean values for E2 and P were 159.0 +/- 17.43 and 281.769 +/- 13.58; 133.75 +/- 18.45 and 265.89 +/- 18.12; 128.57 +/- 14.66 and 206.103 +/- 13.296 respectively. Only the differences between the mean number of corpora lutea and mean progesterone were statistically significant (P less than 0.001) (0.02 greater than P greater than 0.01) respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

Experimental endometriosis and fertility: compared effects of an antigonadotropin (danazol) and an antiprostaglandin (indomethacin).

The possible role of prostaglandins in infertility associated with endometriosis is not fully understood. We therefore compared the efficacy of danazol, the drug chosen for treating this disease with that of indomethacin, an anti-prostaglandin, in rats affected with experimentally produced endometriosis. Endometriosis was induced in two groups of ten rats. The rats in group A were given danazol orally and those in group B were given peritoneal injections of indomethacin. The resulting fertility rates were very good in group B and less so in group A. Group A showed better anatomical findings, but group B gave improved results regarding adhesions.

Administration, Oral↗