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Biomedical subjects

R M Ward

Publications and source records attributed to R M Ward.

67 records · Page 4Linked to original sources
PubMed1978

Cellular immunity to P. acnes in the normal population and patients with acne vulgaris.

Patients with varying degrees of acne, acne-free adult controls and samples of cord blood were investigated for cell mediated immunity to P. acnes using a leukocyte migration inhibition test. Despite the fact that the mean migration index tended to decrease with acne severity, only the patients with severe acne showed cell-mediated immunity. It is suggested that when cellular immunity arises it is a late event which may contribute to inflammation but is probably not a factor in its initiation.

Acne Vulgaris↗
PubMed1977

Prognosis in well differentiated noninvasive carcinoma of the bladder based on chromosomal analysis.

In this series of 27 consecutive patients with well differentiated noninvasive carcinoma of the bladder, cytogenetic analysis repeatedly performed showed marker chromosomes in curative cytoscopic resections of 15 of the patients. In 14 of the 15 patients, recurrent carcinoma developed. Of the 12 patients without markers, one patient had a recurrence; the remaining 11 have been free of recurrence up to eight years after diagnosis. In this long term, although limited, experience with early carcinoma of the bladder, marker chromosomes have been a highly accurate prognostic aid.

Chromosome Aberrations↗
PubMed1976

Meningitis due to combined infections. Association of Haemophilus influenzae type B and Clostridium perfringens.

Haemophilus influenzae type B and Clostridium perfringens were recovered simultaneously from the cerebrospinal fluid of a patient with purulent meningitis. No antecedent history of head trauma was present to explain the coexistence of the anaerobe with Haemophilus organisms. A review of the literature on mixed meningitis indicates that no previous cases of anaerobes have been reported in uncomplicated meningitis due to multiple organisms. In addition, the recovery of clostridia is extremely unusual in the absence of an identifiable portal of entry. We have identified two additional cases of clostridia infection in the central nervous system and recommend that anaerobic organisms be considered in selected cases of meningitis.

Ampicillin↗
PubMed1976

Cytogenetic analysis: a potential index for recurrence of early carcinoma of the bladder.

In 15 cancer patients cystoscopic resection or biopsy coupled with cytogenetic analysis at intervals of 3 to 69 months showed persistence of chromosomal patterns with markers (abnormal chromosomes) in 4 of 7 non-invasive and in 6 of 8 submucosal invasive carcinomas. Recurrence was limited to but constant in those carcinomas containing markers. Marker chromosomes have potential value as a prognostic aid. Further, the triad of tetraploidy, markers and submucusal invasive moderately well differentiated carcinoma appears to carry such a lethal prognosis as to militate for early radical resection.

Carcinoma, Transitional Cell↗
PubMed1976

The aftereffect of tracking eye movements.

When observers tracked moving stripes across a background either of stationary stripes, or of stripes moving in the opposite direction, they saw a clear motion aftereffect when the stripes stopped moving. The direction of this aftereffect was opposite to that of the previously tracked stripes, and was thus the same as the direction of the retinal movement of the non-tracked stripes. This aftereffect of tracking was shown not to depend upon slippage of the tracked contours on the retina during tracking, or upon the saccadic phase of optokinetic nystagmus. The effect showed storage over a period of time with the eyes shut. It appears that the effect is due to induced movement, and arises originally from stimulation of the retina by background contours in the tracking phase. This was shown by confining the view of the moving target to one eye, while permitting both eyes to be exposed to background stimulation during tracking. After such stimulation the magnitude of the aftereffect was equal in the two eyes.

Electroretinography↗
PubMed1973

Growth of Hansenula holstii on cadavers.

Growth of a yeast was observed on prosected cadavers used for demonstration purposes in a medical school. An asporogenous yeast was isolated and identified as an atypical form of Hansenula holstii by analysis of the extracellular polysaccharide. The isolate showed resistance to embalming fluid but was eventually eradicated by addition of picloxidine digluconate to the fluid.

Antifungal Agents↗
PubMedDate not supplied

Fifty-three month persistence of ring chromosome in noninvasive bladder carcinoma.

In a recurrent noninvasive papillary carcinoma of the bladder cytogenetic analysis by the direct technique was carried out on cystoscopic biopsies obtained at 53 month intervals. Persistent similar karyotypic abnormalities including aneuploidy, and ring and other marker chromosomes, the hallmarks of invasive cancer, were present in both specimens. In the 1973 specimen, DNA banding was identified in 35 per cent of the metaphases and in 56 per cent of the karyotypes. The continuing abnormal chromosomal silhouette of this tumor supports the stemline cell concept for malignancies, even when applied to such relatively benign neoplasms as this noninvasive carcinoma of the bladder.

Carcinoma in Situ↗