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Biomedical subjects

R M Turner

Publications and source records attributed to R M Turner.

53 records · Page 3Linked to original sources
PubMed1980

Involving parents in special programming.

Parent programming is defined as direct services to parents which may include assistance in managing personal or family life as well as assistance in developing knowledge, skills and attitudes. The content and methodology of parent programming should be based on the beliefs and assumptions of both parents and professionals. Competency-based programming is presented as a promising approach to improving parent competence. Results of initial studies in parent competency identification, prioritization and assessment are discussed along with procedures for instructional programming.

Adult↗
PubMed1978

Recurrent abdominal pain in childhood.

One hundred and sixty-two children (57 boys and 105 girls), aged between three and 15 years and suffering from recurrent abdominal pain, were seen in general practice in Thamesmead during a seven-year period. Only five were found to have possible organic causes for the pain. Comparison with a control group showed that the close relatives of children with pain consulted doctors more often, had had more abdominal complaints and operations, a higher rate of psychiatric illness and referral, and more known marital problems. Relations between mothers and children with recurrent pain were often unstable and inconsistent. The clinical picture was unhelpful and investigation unproductive.Recurrent abdominal pain in childhood is often a reflection of family disorder, and assessment of the state of the family should precede decisions on management.

Abdomen↗
PubMedDate not supplied

Using schemas for diagnosis.

Medical diagnosis can be considered a planning task: actions are decided on, then executed. However, unlike traditional planning tasks, new information can arise any time, changing the situation and invalidating the plan. In order to cope with this, the reasoner must be able to interleave planning with plan execution. Our approach to this problem is called schema-based reasoning. In this approach, the reasoner's procedural knowledge is represented as schemas, small packets of procedural knowledge which can be used to achieve a goal. When a new goal arises, the reasoner uses the goal and the features of the current consultation to retrieve an appropriate schema from memory; the schema is then applied to achieve the goal. If several schemas are active, the reasoner chooses between them using information about the current situation and information from strategic schemas. Our approach is implemented in MEDIC, a schema-based diagnostic reasoner whose domain is pulmonology.

Artificial Intelligence↗
PubMedDate not supplied

Low-dose metrizamide spinal computed tomography in outpatients.

Delineation of the thecal sac in CT can be improved by the presence of intrathecal metrizamide. This may be especially helpful in postoperative patients in whom the landmarks are often obscured by epidural scarring. Metrizamide-enhanced CT was performed on outpatients using 2 1/2 ml metrizamide (170 mg I/ml). Follow-up is available on 40 patients. The procedure was well tolerated with only three instances of severe headache, one case of vomiting, and no reported seizures. Adequate opacification was obtained at 92% of the levels examined with fair opacification at the remainder of the levels. This technique is considered a safe and useful outpatient procedure.

Adult↗
PubMedDate not supplied

MR of soft tissue chloroma in a patient presenting with left public and hip pain.

A patient with a history of chronic granulocytic leukemia presented with hip and pubic pain. Magnetic resonance study showed a mass infiltrating the obturator externus muscle, which was biopsied under CT guidance. Pathology of the mass was chloroma. Magnetic resonance can be extremely valuable in determining the etiology of hip and pubic pain in patients with a history of leukemia.

Adult↗
PubMedDate not supplied

Molecular genetic analysis of two human sperm fibrous sheath proteins, AKAP4 and AKAP3, in men with dysplasia of the fibrous sheath.

Dysplasia of the fibrous sheath (DFS) is characterized by male infertility, asthenozoospermia, and morphologically abnormal flagella that possess a severely malformed fibrous sheath. In many cases, DFS is familial, suggesting a genetic component. Human AKAP4 and AKAP3 are structural proteins of the fibrous sheath that also function to anchor protein kinase A to this structure via the regulatory subunit of the kinase. We hypothesized that defects in either AKAP4 or AKAP3 might cause DFS. No quantitative or qualitative differences between patients with DFS and normal controls were detected when sperm proteins were analyzed by either silver staining or immunoblot analysis using antibodies raised against AKAP4 and AKAP3. Additionally, AKAP4 and AKAP3 from DFS sperm retained the ability to bind the regulatory subunit of protein kinase A. Localization at the light and electron microscopic levels showed that AKAP3 and AKAP4 localized correctly to the FS of the amorphous flagellum in DFS sperm. Partial sequence analysis of the AKAP4 and AKAP3 genes in patients with DFS did not identify any significant alterations in potential AKAP4/AKAP3 binding regions, suggesting that the two proteins interact normally in DFS sperm. Our results did not find evidence to support the hypothesis that mutations in either gene are responsible for DFS in humans.

Adult↗