Biomedical subjects

R M Schmidt

Publications and source records attributed to R M Schmidt.

At least 91 records · Page 5Linked to original sources

PubMed1975

The presence of hemoglobin S and C Harlem in an individual in the United States.

The first reported case of hemoglobin S and C Harlem in an individual is described. The patient, a 35-yr-old female, had numerous crises during adolescence and early adulthood, but these occurred more infrequently as she grew older. Chemical evidence is presented for the characterization of both variant hemoglobins. The clinical course of this individual with Hb S in combination with Hb C Harlem appears to be similar to that for persons with sickle cell anemia.

Adult↗

PubMed1975

Comparison of methodologies for thalassemia screening by Hb A2 quantitation.

An efficient, reliable, inexpensive screening test for beta-thalassemia triat is required before the National Cooley's Anemia Control Act can be carried out. Densitometry of hemoglobin samples separated by cellulose acetate has become a routine procedure to quantitate Hb A2 and thereby indicate beta-thalassemia trait carriers. To determine the utility of densitometry in quantitation of Hb A2, we evaluated three densitometers marketed in the United States. Individuals with genetically proved beta-thalassemia trait and normal Hb AA controls were studied. Two analytic procedures (elution and column chromatography) for Hb A2 quantitation were used as reference methods. Densitometry was shown to be unsatisfactory for detecting beta-thalassemia-trait carriers. We recommend that a unified approach to the detection of anemia, which would include thalassemia trait, be developed in the United States rather than free-standing thalassemia screening centers and clinics.

Chromatography, Gel↗

PubMed1975

Identification of human hemoglobins by use of isoelectric focusing in gel.

Newly-developed gel isoelectric focusing techniques provide for rapid and correct identification of human hemoblobins. With this technique, we examined samples previously identified by the National Hemoglobinopathy Standardization Laboratory of the Center for Disease Control. A wide variety of both normal and abnormal hemoglobins was included in the 134 different specimens examined. The isoelectric points (pl's) were precisely determined; no discrepancies with results by standard techniques of identification were found. The method is accurate and precise. It is proposed as a powerful adjunct to other laboratory methods suitable for use in a hemoglobinopathy reference laboratory or specialized hematology service laboratory.

Electrophoresis, Polyacrylamide Gel↗

PubMed1975

[Studies on protein genetic factors in multiple sclerosis and psychoses].

In more than 200 cases of multiple sclerosis, psychosis and cyclothymia, the Hp types are studied with the help of polyacrylamide gel electrophoresis (Schreyer and Schaible, 1967) and the Gc types wtih agar gel electrophoresis (Schlesinger, Vogt and Prokop, 1963). All Hp and Gc types were found in these diseases, but there was no frequent occurence of any particular type in multiple acleroses of psychoses. According to our results, there is no interdependence between these diseases and the Hp and Gc types.

Haptoglobins↗

PubMed1975

[Frequency pattern of alpha waves in the early stages of cerebrovascular circulation disorders].

In this study 201 EEG curves are interpreted belonging to patients suffering from incipient disturbances of the cerebral circulation. The patients were divided into 3 groups according to age (group I, 30-40 years; group II, 40-50 years; group III, 50 years and over). In group I there prevailed a rate of 11-12 alpha waves per sec., and a slower rate was hardly ever found; in group III the frequency pattern was quite different. This decreased frequency of the waves could be confirmed by statistics. We believe a direct link can be assumed to exist between a decrease in frequency and the beginning of disturbed cerebral circulation.

Adult↗

PubMed1974