Biomedical subjects

R M Salazar Villa

Publications and source records attributed to R M Salazar Villa.

9 recordsLinked to original sources

PubMedDate not supplied

[Symptomatic dermatographism and HLA antigens].

This research reports the unique case of manifestation of symptomatic dermographism which includes all of its twenty five members of the family. Probing a genetic transmission autosomal dominant manner and taking into account the highly probable role of HLA in this illness. The symptomatic dermographism correspond to a group of physical familiar urticarias with symptoms appearing in early childhood and evolving throughout adulthood with seldom periods of remission. Due to the fact that all patients were affected, it was not possible to realize a typification of HLA antigens with persons not affected, to establish a relationship with the data obtained. However, results show a significant association of haplotypes; HLA A2 (78.95), B16 (68.4%), A1 (47.3%), and B5 (42.5%) among the most important. This is the first research that reports the analysis of HLA within the physical familial urticarias.

Adolescent↗

PubMedDate not supplied

[The importance of pollinosis in the Valley of Mexico].

The climatic conditions and the vegetation in the valley of Mexico are analyzed in virtue of their modification during the last few years which have consequently altered the surrounding ecological systems. In this article, we were particularly interested in describing the botanical characteristics of the gimnospermas, an abundant vegetation in Mexico.

Geography↗

PubMedDate not supplied

[Asthma induced by aspirin and arachidonic acid metabolites. Role of leukotrienes (third part)].

Although the mechanism of aspirin-induced asthma is unknown, it has been suggested that adverse nasal and bronchial reactions are caused by an increased production of lipoxigenase products. In examining the hypothesis of inhibition on cycloxigenase, we support evidence in favor of this theory. We have measure the release of urinary LTE4, TXB2 and 11-dehydro-TXB2 of aspirin-induced asthmatics and controls by radioimmunoassay and HPLC methods during aspirin challenge and after desensitization. The over production demonstration of urinary LTE4 during aspirin challenge and the decrease after desensitization in inversal direct proportion manner with TXB2 suggest a "shunting" of the arachidonic acid metabolites of the target cells. Whichever theory is to be pursed further, it must also accommodate the clinical effect of aspirin desensitization.

Arachidonic Acid↗

PubMedDate not supplied

[Asthma induced by aspirin and arachidonic acid metabolites. II. The role of leukotrienes (part four)].

Although the mechanism of aspirin-induced asthma is unknown, it has be suggested that adverse nasal and bronchial reactions are caused by an increased production of lipoxygenase products. We have measured the release of urinary LTE4, TXB2 and 11-dehydro-TXB2 of aspirin induced asthmatics and controls by radioimmunoassay and HPLC methods during aspirin challenge and after desensitization. The overproduction demonstration of urinary LTE4 during aspirin challenge and the decrease after desensitization in inversal direct proportion manner with TXB2 suggest a "shunting" of the arachidonic acid metabolites of the target cells. Whichever theory is to be pursued further, it must also accommodate the clinical effect of aspirin densitization.

Arachidonic Acid↗

PubMedDate not supplied

[Aspirin-induced asthma and arachidonic acid metabolites. In search of answers to an enigma. Part 2].

Acetylsalicylic acid is one of the most commonly used drugs and high on the list of causes of drug reactions. Since early publication on 1902 by Hirschberg, a great deal of information has emerged on aspirin sensitivity, including data on epidemiology, further characterization of the two major subtypes of sensitivity (bronchospastic and urticarial types), hereditary aspects, cross-reactions to other nonsteroidal antiinflammatory drugs, and methods of desensitization. Although the pathogenesis of aspirin-sensitive asthma remains unknown, several theories has been proposed to explain the disease enigma.

Anti-Inflammatory Agents, Non-Steroidal↗

PubMedDate not supplied

[Asthma induced by aspirin and arachidonic acid metabolites. I. In search of answers to an enigma (first part)].

Acetylsalicylic acid, one of the most commonly used drugs and high on the list of causes of drug reactions. Since early publication on 1902 by Hirschberg, a great deal of information has emerged on aspirin sensitivity, including data on epidemiology, further characterization of the two major subtypes of sensitivity (bronchospastic and urticarial types), hereditary aspects, cross-reactions to other nonsteroidal antiinflammatory drugs, and methods of desensitization. Although the pathogenesis of aspirin-sensitive asthma remains unknown, several theories has been proposed to explain the disease enigma.

Arachidonic Acid↗

PubMedDate not supplied

[Metabolic changes in arachidonic acid during aspirin desensitization].

Aspirin sensitivity occurs in 10% of all asthmatics patients. In this subset of asthmatics, nasal congestion and bronchospasm occurs between 30-180 minutes after ingestion of aspirin. Following a respiratory reaction to aspirin, all patients can be desensitized to aspirin by repetitively introducing small and then larger doses of aspirin until the asthmatic subject can ingest 650 mg of aspirin without adverse effect. The mechanism of aspirin sensitivity are incompletely understood. And the reasons why ASA desensitization occurs universally are unknown. In this study, known ASA sensitive and control insensitive asthmatics were challenged with ASA. Urine was collected before, during induced bronchospasm, and after ingestion of 650 mg of ASA when the adverse effect (ie., acute desensitization) had subsided. Excretion levels of cyclo-oxygenase and lipoxygenase products in the urine were determined.

Acetaminophen↗

PubMedDate not supplied

[Immunotherapy in allergy].

This report includes a partial interpretation of the possible mechanisms of action related with the efficacy of specific immunotherapy with allergens. This cannot be explained by only one mechanism which regulates the immune reaction, which is why there is the relief that there is a large field in immunology which has yet to be explore.

Allergens↗

PubMedDate not supplied

[Use of transfer++factor in allergic bronchial asthma].

The therapeutic panorama of immunomodulation and its effects on the modification of the immune reaction is reviewed. Particular reference is made to the transfer factor as a therapeutic element in bronchial asthma, which insures its efficacy or innocuity.

Adjuvants, Immunologic↗