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Biomedical subjects

R M Rubin

Publications and source records attributed to R M Rubin.

At least 55 records · Page 3Linked to original sources
PubMed1980

Mode of respiration and facial growth.

There is a substantial amount of evidence to support the theory that the spatial relationship of the mandible to the craniomaxillary complex is influenced, in part, by the function of the muscular elevators of the mandible. One factor acting on the elevators of the mandible is the rest position of the mandible, which may be influenced by the patient's mode of respiration. Obstruction of the nasal airway is followed by the lowering of the mandible to establish an oral airway. Allergic rhinitis is one cause of nasal airway obstruction. There are reports that avoidance of the ingestion of foreign airway. The orthodontist should recognize early signs of the development of the long face syndrome and make appropriate referrals to medical colleagues to promote nasopharyngeal health.

Airway Obstruction↗
PubMed1979

Facial deformity: a preventable disease?

By training, the orthodontist is uniquely qualified to be the primary monitor of facial growth. He should assess the mode of respiration at approximately two years of age and confer with the pediatrician, allergist and otolaryngologist to institute appropriate medical management of any developing problems. He must educate his colleagues in medicine and dentistry to recognize those conditions that can produce facial deformity. The primary care physician should appreciate that obstruction of the nasal airway is an important dysfunction. Medical and surgical intervention and, above all, good preventive management must be instituted to promote patency of the nasal airway. Allergy is a disease of modern man. It is possible that better prenatal care, breastfeeding, the avoidance of common allergens, and appropriate surgical and medical management to reduce the incidence of respiratory obstruction in growing children will result in fewer cases of cleft lip and palate and other craniofacial anomalies.

Airway Obstruction↗
PubMed1979

Microvasculature of the cruciate ligaments and its response to injury. An experimental study in dogs.

UNLABELLED: The normal vascular anatomy of the cruciate ligaments was investigated in eight dogs by microangiography, histology, and tissue-clearing (Spalteholz) techniques. The vessels were found to originate predominantly from the soft tissues (infrapatellar fat pad and synovial membrane) of the joint. The vascular response to partial surgical transection of the anteromedial mid-portion of the anterior cruciate ligament was evaluated in twelve dogs. This response, which was vigorous and extensive, appeared to arise from the soft tissues. Resection of the infrapatellar fat pad and synovial membrane at the time of injury tended to decrease this response. Spontaneous healing of the defect had not occurred in either group by eight weeks. CLINICAL RELEVANCE: The predominant soft-tissue, as opposed to osseous, origin of the blood supply to the cruciate ligaments may be an important consideration in the repair of these structures. The preservation and utilization of the infrapatellar fat pad and synovial envelope may optimize the vascular response and healing of the ligament.

Adipose Tissue↗
PubMed1976

Effects of temperature and time on the infectivity of Cryogenically preserved samples of Anaplasma marginale- infected erythrocytes.

The effects of temperature (25 C) and time (2, 4, 6, 8, 12, 24, 48, 72, 96 hours and 5, 13, and 19 days) were determined on thawed samples of Anaplasma marginale-infected erythrocytes cryogenically preserved with dimethyl sulfoxide and frozen in liquid nitrogen. Inoculation into splenectomized calves indicated that infectivity was not destroyed by either time or temperature from 2 to 72 hours, but was destroyed at 96 hours. The incubation periods of the disease in inoculated splenectomized calves increased in proportion to the length of time the samples were held at 25C.

Anaplasma↗
PubMed1975

Porous hydrophilic polymer: good and bad news in the orthopedic application of cruciate ligament substitution.

In the configuration used, the Hydron sponge did not enhance the ingrowth of bone into the Dacron for prosthesis anchorage. In fact, the presence of the Hydron seemed to retard such ingrowth, even though there was bony incorporation of portions of the Hydron polymer. Fixation was more rigid when Dacron was implanted bare. Hydron sponge does not appear to remain intact within a joint. It would not seem suitable for intra-articular protection of a prosthesis or local delivery of antibiotics here. We did not search further for the polymer in the regional lymph nodes. Hydron sponge is capable of eleciting an unusual phenomenon of woven bone formation. This is "good news" for its potential, but realization of such potential will certainly require additional study. Double and triple interval fluorochrome labelling would be especially helpful in further studying the localization and rate of this bone formation.

Acrylates↗
PubMed1967

The motor innervation of the rat urinary bladder.

1. The post-ganglionic nerves visible in silver-impregnated sections of a normal rat bladder were absent 14 days after both pelvic ganglia had been ablated. After ablation of one ganglion the distribution of nerve trunks in either side of the organ was unchanged. Post-ganglionic axons from either side appear to distribute bilaterally.2. The acetylcholine (ACh) content of the rat bladder was reduced from control by 50% after the post-ganglionic nerves from one ganglion had degenerated. However, the ACh content in the two halves of the bladder sectioned along the mid line was the same after one nerve had degenerated.3. Motor responses of bladder preparations elicited during stimulation of both pelvic nerves were compared with responses elicited when each nerve was stimulated separately. In three-quarters of the animals the sum of the individual responses exceeded the response to combined nerve stimulation by no more than 20%. The functional overlap between the two groups of motor nerves to the bladder was therefore no greater than this amount in most animals.4. Motor responses of normally innervated bladder preparations elicited in vitro by transmural stimulation were compared with responses elicited after the post-ganglionic innervation from one side had degenerated. The mean response of bladders with half their innervation was 50-65% of the mean response of bladders normally innervated. The functional overlap by the two groups of nerves was found to be no greater than 15%.

Acetylcholine↗
PubMedDate not supplied

Prevention of knee instability. Experimental model for prosthetic anterior cruciate ligament.

Loss of the anterior cruciate ligament (ACL) in the dog results in a predictable type of arthritis. This condition can be prevented by successful prosthetic substitution of the anterior cruciate ligament (ACL). The condition is a practical model, and a sensitive index of success and failure for evaluation of prototype prostheses. Changes in the joint can be differentiated on the basis of cruciate insufficiency and reaction to the synthetic implant. The model was defined by replacing the ACL with a mesh or tape Dacron prosthesis in 16 Beagle dogs. Gait and anterior drawer sign are unreliable parameters of ACL insufficiency in dogs. At sacrifice up to 3 years postoperatively, 8 joints out of 32 joints were without arthritic changes. Arthritis developed in all joints in which the prosthesis elongated or broke. Failure always occurred intra-articularly at the mouth of a bone tunnel. Successes were inconsistent even with a single material and animal breed. The drillhole techniques used in ACL reconstructions are difficult to standardize. Variability in placement of the prosthesis is compounded by cutting action of bone edges. Porous mesh did not provide a lattice for true ligament regeneration through the joint. Fixation was not a problem in this series.

Animals↗