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Biomedical subjects

R M Rose

Publications and source records attributed to R M Rose.

At least 145 records · Page 8Linked to original sources
PubMed1979

Effects of increased testosterone secretion on the behavior of adult male rhesus living in a social group.

Selected members of an all-male social group of rhesus monkeys were treated with twice-weekly injections of human chorionic gonadotropin (HCG) to determine the effects of the consequently increased androgen secretion on social behavior. Radioimmunoassay of blood samples confirmed significant increases in serum testosterone levels in each of 4 subject, but only 3 of these showed significant behavioral changes. The basic social structure of the group, including the dominance hierarchy, was not disrupted by the treatment with HCG. Rather, the behavioral changes which did not occur appeared to be intensifications of previously existing social relationship.

Aggression↗
PubMed1979

The relationship of the central motor pattern to the feeding cycle of Lymnaea stagnalis.

Electromyographic recordings from the buccal muscles of Lymnaea during feeding has shown that there are 4 component phases in the feeding cycle. Cinephotography of feeding cycles has confirmed that these correspond to protraction, 2 phases of retraction, and an inactive phase. The 4 phases of muscle activity can also be related to the cycle of neural activity described previously (Benjamin & Rose, 1979). Thus types 6, 4 group, and type 8 cells are motoneurones involved in protraction and the two retraction phases, while the type 5 cell fires in the inactive period. The combination of physiological and anatomical approaches has led to the suggestion that the single and double input cells described by Benjamin & Rose (1979) are involved with the control of buccal and oesophageal activity respectively.

Action Potentials↗
PubMed1979

Central generation of bursting in the feeding system of the snail, Lymnaea stagnalis.

The central generation of burst activity was investigated in the buccal ganglia of Lymnaea. Eight different patterns of burst activity were generated by one or two consecutive phases of compound synaptic potentials resulting from activity of neurones. These inputs acted upon the different endogenous properties of buccal neurones such as post-inhibitory rebound and spike adaptation. Effects of synaptic inputs were reinforced by by electrotonic coupling of some buccal neurones of the same type.

Action Potentials↗
PubMed1978

Prevalence of depression over a 12-month period in a nonpatient population.

A nonpatient population of air traffic controllers, all of whom remained employed during the observation period, was examined monthly for one year for level of depression using the Zung Self-Rating Depression Scale. The average monthly prevalence of depression was 9.1%, with 7.0% at the symptom level, 1.9% at a level comparable to outpatients, and 0.2% with moderately severe levels. These figures were generally similar to those for other reported population groups, although exact comparisons were difficult because of the preselection for health in this population. Two patterns of depression were observed. One was characterized by an acute, episodic symptomatology returning to nonsymptomatic levels for most of the year, similar to Research Diagnostic Criteria (RDC) category "episodic minor depressive disorder." The other showed a chronic, fluctuating course with significant depressive symptomatology over half the year, similar to RDC category "chronic and intermittent minor depressive disorder."

Adult↗
PubMed1978

Changes in testosterone and behavior during adolescence in the male rhesus monkey.

Five adolescent male rhesus were followed for 3 years, from age 2 through age 4, with the collection of monthly testosterone levels, along with observation of behavior. Testosterone levels showed initial rises by age 3, but did not show the adult male seasonal pattern until 4. Play behavior fell significantly from age 2 to age 3, while sex behavior showed seasonal increases in both Year 2 and Year prior to the rise in plasma testosterone. The number of adult males in the social group may influence the timing of the rise in testosterone during adolescence. Injury may also serve to delay the increase in testosterone in males during their third year of development.

Age Factors↗
PubMed1978

The assessment of life change stress: a comparative and methodological inquiry.

A comprehensive life events questionnaire was administered to 416 men. Total life change scores were computed from published normative weights and from individuals' own ratings of events that occurred. The results showed that the rank order of life events was highly correlated between our sample and the original normative groups. However, in the population of men we studied, there were significant differences between the total life event scores derived by summing the published normative weights and the total adjustment or distress reported by those men who experienced the events. Other results indicated that life event scores based on normative weights reflect more on the number of life events that are experienced, whereas life change scores based on individuals' ratings may better reflect on the potential impact of life change. Finally, the psychometric properties of several life change inventories are poor.

Adaptation, Psychological↗
PubMed1978

Health change in air traffic controllers: a prospective study. I. Background and description.

The background, rationale, and design of a 3-year prospective study of health change in 416 air traffic controllers is described. This study was designed to assess the relevant variables that might predict future physical and psychological health change. This report describes the major variables that were assessed in all participants, which included endocrine, cardiovascular, and behavioral differences in response to work, the occurrence of significant life events, work attitude and morale, availability and usefulness of psychosocial supports, and job commitment and performance. Future reports will describe the contribution, both individually and interactively, of these various factors to the risk for future illness. A major hypothesis to be tested by this study is that health change among air traffic controllers can be predicted by differential responsivity to work.

Adaptation, Physiological↗
PubMed1978

Is chondromalacia patellae a separate clinical entity?

The articular cartilage of the patella was studied in 100 knees at necropsy. In twenty-one of these knees the cartilage changes were related to the trabecular architecture of the underlying bone. It would appear that the initiation and location of cartilage damage and its rate and degree of progression are related to the relative stiffness of the underlying cancellous bone. On the basis of our observations we suggest that the diagnosis "chondromalacia of the patella" should be reserved for patients with asymptomatic or transiently symptomatic fibrillation of the articular cartilage of the central medial patellar facet. Those patients with persistent patellofemoral pain should be considered to have some other syndrome.

Cartilage Diseases↗
PubMed1978

Diurnal variation in plasma testosterone and cortisol in rhesus monkeys living in social groups.

Concentrations of cortisol and testosterone in the plasma of adult male rhesus monkeys living in social groups were determined during a 27-h period. Capture and venipuncture of experienced, conditioned animals did not lead to a fall in the concentration of testosterone in the plasma during the 90 min immediately after removal from the group. Both plasm cortisol and plasma testosterone concentrations showed a significant fall and rise in samples collected every 3 h during a 27-h period, even though there was considerable individual variation. During the autumn breeding season, animals showed higher concentrations of testosterone at both 10.00 and 22.00 h compared with those observed at the same times during the summer. Even though animals demonstrated significant diurnal changes, testosterone samples withdrawn at the same time of day (10.00 h) on consecutive days were significantly correlated with one another (r = 0.65, n = 27, P less than 0.01), suggesting the usefulness of sampling once a day to study potential environmental influences on plasma testosterone concentrations.

Animals↗
PubMed1977

Behavioural and hormonal responses of male rhesus monkeys introduced to females in the breeding and non-breeding seasons.

Six adult male rhesus monkeys were introduced individually to an all-female group for 10 days during the mating season. The initial aggressive responses of the females were rapidly replaced by positive social behaviour, and each male achieved alpha status and had access to social and sexual partners. A repetition of this paradigm in the non-breeding season produced significantly more female aggression, and no male attained high rank or engaged in sexual or other social behaviour. Male testosterone levels rose following introduction to the females in both seasons, but were significantly higher during the breeding season. Hormonal levels following removal from the females suggest a complex interplay between social, sexual and seasonal variables and recent social experiences. The differences in female social behaviour with newly introduced males, as a function of season, suggest an explanation for the seasonal limitation of male troop transfers.

Aggression↗