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Biomedical subjects

R M Rose

Publications and source records attributed to R M Rose.

At least 19 recordsLinked to original sources
PubMed1992

The effect of aerosolized recombinant human granulocyte macrophage colony-stimulating factor on lung leukocytes in nonhuman primates.

The number and function of myeloid cells in the lungs are critical determinants of health and disease. To examine whether these cells can be modulated in vivo by a colony-stimulating factor (CSF), recombinant human granulocyte macrophage-CSF (GM-CSF) was given to cynomolgus monkeys by either continuous intravenous infusion (7,200 U/kg/day) for 2 wk or by aerosol exposure to 10(7) U on 1 or 2 consecutive days. At intervals after the initiation of GM-CSF administration, animals underwent bronchoalveolar lavage (BAL) and had peripheral blood sampled to characterize changes in lung and circulating phagocytic cells. Compared with animals exposed to bovine serum albumin, there was an increase in the total number of BAL cells retrieved. This increase was greatest in animals receiving aerosolized GM-CSF, and it was the result of more macrophages and neutrophils. Both lung macrophages and blood neutrophils from animals exposed to aerosolized GM-CSF exhibited an augmented respiratory burst in response to phorbol myristate acetate. Lung macrophages from GM-CSF-exposed animals exhibited increased capacity to bind and/or ingest opsonized and unopsonized Staphylococcus aureus. Despite functional activation of lung phagocytic cells, biochemical analyses of BAL fluid for markers of lung injury revealed an increase in only some parameters in the GM-CSF group. Intravenous administration of GM-CSF had the expected effect on augmenting the number of myeloid cells in the bloodstream. Aerosolized GM-CSF produced a transient effect on circulating myeloid cell number between 3 and 5 days after exposure.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Inhalation↗
PubMed1979

Life changes. Do people really remember?

The question, "How well do people remember life changes?" was approached in a longitudinal study of nearly 400 healthy men in a responsible profession. Three scales for assessing life changes were administered by questionnaire at two examinations nine months apart. The subjects were asked to report life change events occurring during a specific six-month period--that which immediately preceded the first examination. For all three life change scales there was substantial forgetting over the interval between reports, with a second report yielding total scores 34% to 46% less than those from the first report for the same period. The amount of change over time varied greatly across persons. These findings raise serious questions about the validity of retrospective studies of life change and illness when the period being reported is greater than six months in the past. They do not, however, jeopardize the potential of the method for prospective studies.

Adult↗
PubMed1979

The effects of radiation sterilization on the properties of ultrahigh molecular weight polyethylene.

The effects of radiation sterilization on ultrahigh molecular weight polyethylene were explored by freeze fractures, electron spin resonance, absorption of aqueous media, density measurements, small-angle and wide-angle x-ray scatter, differential scanning calorimetry, infrared and ultraviolet-visible spectrometry, static and dynamic mechanical fatigue measurements, and standard environmental stress cracking measurements. The rate of fluid absorption increased significantly due to the appearance of carbonyl groups. As the fluids were absorbed, density increased and small-angle x-ray scatter (SAXS) intensity diminished slightly, as expected. Small changes in mechanical properties (e.g., tensile properties and dynamic spectrum) were always consistent with the cross-linking which occurs after irradiation; the only significant mechanical deterioration was in the fatigue properties. The nonspherulitic, inhibited crystallinity which characterized this material and which is responsible for its excellent static resistance to environmental stress cracking was not at all changed.

Absorption↗
PubMed1979

Psychoendocrinology of the menstrual cycle: I. Enjoyment of daily activities and moods.

Thirty-three women participated in a study of the relationship between moods and enjoyment of activities during the menstrual cycle. All subjects had normal cycles and were screened for psychological health. None were taking oral contraceptives. Each subject filled out daily the Profile of Mood States (POMS) and the Social--Sexual Activities Log (SAAL). They also completed the Moos Menstrual Distress Questionnaire (MDQ) once a month. The SSAL was developed as part of this research in order to provide a means of assessing subjective enjoyment of daily activities. SSAL items were developed from semistructural individual interviews and assessed behavior across eight different categories. Results suggest that the SSAL is a reliable self-report instrument. Although there were no changes in either moods or enjoyment of activities as a function of cycle phase with either the POMS or the SSAL, scores on the MDQ showed the usual cycle-related differences. These findings raise questions concerning the validity of retrospective methods in general, and of the MDQ in particular, as techniques for assessment of personal distress during the menstrual cycle. Equally important, the results suggest that when changes in psychological states are assessed concurrently during the menstrual cycle, the fluctuations observed in a healthy population are minimal.

Adult↗
PubMed1979

Psychoendocrinology of the menstrual cycle: II. The relationship between enjoyment of activities, moods, and reproductive hormones.

Fourteen women served as subjects in a study of the relationships between emotional states, enjoyment of activities, and reproductive hormones. Each subject was psychologically and physically healthy, had a documented history of normal and regular menstrual cycles, was not taking oral contraceptives, and was involved in an ongoing heterosexual relationship. Each woman participated for at least two complete menstrual cycles. The Profile of Mood States and the Social-Sexual Activities Log were filled out daily; other questionnaires were completed less frequently. Blood was drawn between 3 and 5 times/week and was analyzed, using radioimmunoassay methods, from plasma levels of estradiol, progesterone, and luteinizing hormone. Twenty-seven of the twenty-eight cycles appeared to be normal and ovulatory, according to accepted endocrinological criteria. Results showed that in this sample of healthy women there was no relationship between mood states or enjoyment of activities and phase of the menstrual cycle, and no relationship between these psychological states and absolute levels of the reproductive hormones estradiol and progesterone.

Adult↗
PubMed1979

Effects of increased testosterone secretion on the behavior of adult male rhesus living in a social group.

Selected members of an all-male social group of rhesus monkeys were treated with twice-weekly injections of human chorionic gonadotropin (HCG) to determine the effects of the consequently increased androgen secretion on social behavior. Radioimmunoassay of blood samples confirmed significant increases in serum testosterone levels in each of 4 subject, but only 3 of these showed significant behavioral changes. The basic social structure of the group, including the dominance hierarchy, was not disrupted by the treatment with HCG. Rather, the behavioral changes which did not occur appeared to be intensifications of previously existing social relationship.

Aggression↗
PubMed1979

The relationship of the central motor pattern to the feeding cycle of Lymnaea stagnalis.

Electromyographic recordings from the buccal muscles of Lymnaea during feeding has shown that there are 4 component phases in the feeding cycle. Cinephotography of feeding cycles has confirmed that these correspond to protraction, 2 phases of retraction, and an inactive phase. The 4 phases of muscle activity can also be related to the cycle of neural activity described previously (Benjamin & Rose, 1979). Thus types 6, 4 group, and type 8 cells are motoneurones involved in protraction and the two retraction phases, while the type 5 cell fires in the inactive period. The combination of physiological and anatomical approaches has led to the suggestion that the single and double input cells described by Benjamin & Rose (1979) are involved with the control of buccal and oesophageal activity respectively.

Action Potentials↗
PubMed1979

Central generation of bursting in the feeding system of the snail, Lymnaea stagnalis.

The central generation of burst activity was investigated in the buccal ganglia of Lymnaea. Eight different patterns of burst activity were generated by one or two consecutive phases of compound synaptic potentials resulting from activity of neurones. These inputs acted upon the different endogenous properties of buccal neurones such as post-inhibitory rebound and spike adaptation. Effects of synaptic inputs were reinforced by by electrotonic coupling of some buccal neurones of the same type.

Action Potentials↗
PubMed1978

Prevalence of depression over a 12-month period in a nonpatient population.

A nonpatient population of air traffic controllers, all of whom remained employed during the observation period, was examined monthly for one year for level of depression using the Zung Self-Rating Depression Scale. The average monthly prevalence of depression was 9.1%, with 7.0% at the symptom level, 1.9% at a level comparable to outpatients, and 0.2% with moderately severe levels. These figures were generally similar to those for other reported population groups, although exact comparisons were difficult because of the preselection for health in this population. Two patterns of depression were observed. One was characterized by an acute, episodic symptomatology returning to nonsymptomatic levels for most of the year, similar to Research Diagnostic Criteria (RDC) category "episodic minor depressive disorder." The other showed a chronic, fluctuating course with significant depressive symptomatology over half the year, similar to RDC category "chronic and intermittent minor depressive disorder."

Adult↗