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Biomedical subjects

R M Preshaw

Publications and source records attributed to R M Preshaw.

At least 37 records · Page 2Linked to original sources
PubMed1979

Randomized sequential trial of parenteral nutrition in healing of colonic anastomoses in man.

Adults who underwent elective colonic resection with anastomosis for both benign and malignant disease were randomly assigned to control or treated groups. Treated patients received daily 50 ml/kg of amino acid solution containing either 10 or 25 g/dl glucose by central or peripheral vein plus 500 ml of commercial soybean emulsion for 24 hours before operation and for 5 consecutive days after. Patients in both groups were examined by roentgenography after a water-soluble contrast enema, between 10 and 14 days after operation, and the integrity of the anastomosis was assessed radiologically without knowledge of the treatment given. Results were assessed by sequential analysis. After 21 pairs of subjects were entered,a boundary was crossed making the area favourable to treatment inaccessible, and the trial was terminated. Forty-seven patients were included in the trial: there were four anastomotic leaks in 23 control subjects and eight leaks in 24 treated subjects. The authors conclude that intensive perioperative parenteral nutrition in patients who undergo routine elective colonic resection does not improve the rate of healing of colonic anastomoses.

Aged↗
PubMed1977

Hemobilia associated with a traumatic arteriovenous fistula.

Although there have been many reports of hemobilia, its association with an arteriovenous fistula within the liver is extremely rare, only two cases having been reported in the world literature. The authors describe a third case in which a gunshot injury to the liver of a 19-year-old man resulted in the development of hemobilia demonstrated radiologically to be associated with an arteriovenous fistula. The condition was successfully managed by ligation of the proximal hepatic artery.

Adult↗
PubMed1976

Liver transplantation in a patient with cholangiocarcinoma and ulcerative colitis.

A 39 year-old patient with cholangiocarcinoma and pre-existing ulcerative colitis was successfully treated by orthotopic liver transplantation. He was given low doses of prednisone and azathioprine and survived for more than 9 months, dying with tumour metastases, thrombosis of the inferior vena cava and an intra-abdominal abscess. At autopsy the homograft showed little evidence of rejection. Preoperatively the patient had septicemia. Removal of his liver was difficult. The discrepancy between donor and recipient in size of blood vessels and the presence of two hepatic arteries in the donor caused problems during the vascular anastomoses. During the operation cardiac arrest occurred. Postoperatively there were several medical and surgical problems, including intraperitoneal and gastrointestinal hemorrhage, paralysis of the right dome of the diaphragm, sinus bradycardia, massive diuresis, peroneal nerve palsy, and one major and three minor episodes of rejection, which were reversed by giving pulse doses of methylprednisolone intravenously.

Adenoma, Bile Duct↗
PubMed1970

Vagotomy.

Explore the source record for details and available documents.

Animals↗
PubMed1969

Secretomotor function of the dorsal motor nucleus of the vagus.

1. The effect of chronic ablation of the dorsal motor nucleus of the vagus on insulin-induced secretion of acid by the stomach has been investigated in conscious cats.2. Destruction of this nucleus results in a persistent profound reduction in gastric secretion of acid under these experimental conditions, while the visceromotor and cardioinhibitory effects of stimulation of the distal end of the acutely transected ipsilateral cervical vagus were unaffected.3. It is concluded that the dorsal motor nucleus is a secretomotor centre.

Animals↗