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Biomedical subjects

R M Lubow

Publications and source records attributed to R M Lubow.

At least 37 records · Page 2Linked to original sources

Hepatitis B vaccine: implications for dental personnel.

The available data indicate that a highly effective vaccine to combat hepatitis B has been developed. In a well-controlled, double-blind clinical study of a high risk group (male homosexuals), this vaccine stimulated the production of anti-HBs in more than 92% of the test group followed for two years. As a generalization, this new vaccine can be described as highly effective, safe, stable, and a welcome addition to preventive medicine. Dentists, in particular oral surgeons and periodontists, are in a high risk category with respect to hepatitis B exposure. This vaccine deserves considerable attention by these groups. All members of the dental profession should seriously consider the use of this vaccine as a personal and public health measure when it becomes commercially available.

Clinical Trials as Topic↗

Particulate contamination of local anesthetic solutions.

Particulate contamination was found in one particular lot number of local anesthetic, lidocaine with 1:100,000 epinephrine. The contaminants were noticed in several cartridges of each container and varied in size from minute to several millimeters. Analysis of the foreign matter revealed the particles to be of a way or puttylike consistency; however, the sterility of the solution was not altered and the pH was still within acceptable limits. The contaminant was most likely wax or a combination of wax, silicone, and glycerin, which are constituents of the rubber stopper and its associated lubricants. This problem was most likely due to temperature changes during storage and shipment, but it was also possibly due to manufacturing discrepancies.

Drug Contamination↗