Search PubMed⌕ Search

Biomedical subjects

R M Kaplan

Publications and source records attributed to R M Kaplan.

At least 109 records · Page 6Linked to original sources
PubMed1993

Quality of life assessment for cost/utility studies in cancer.

The goals of cancer treatment and cancer prevention are to extend life expectancy and to improve quality of life in the years prior to death. Typically, outcomes of cancer treatment are evaluated in terms of survival time. Although quality of life is often measured, interpretation of these outcomes in relation to mortality is difficult. Survival analysis places each individual into one of two categories: alive or dead. Among those alive, all individuals are considered equivalent. Thus, a patient confined to bed with severe symptoms is scored the same as someone who is active and asymptomatic. A General Health Policy Model is proposed as a solution to this problem. The model adjusts life expectancy for diminished quality of life, which is measured using a standardized instrument known as the Quality of Well-being (QWB) scale. The model expresses the effect of treatment in a unit known as a Well-Year or Quality Adjusted Life Year (QALY). These units integrate side-effects and benefits of treatment by combining into a single number, mortality, morbidity, and duration of each health state. Similar methods, such as the Q-TWiST, have been proposed for use in cancer clinical trials. However, the Q-TWiST is a subset of the more general model and carries limitations for cross-disease comparisons. We conclude that general health outcome models can be of considerable value for analysing the costs, risks and benefits of cancer therapies.

Cost-Benefit Analysis↗
PubMed1993

Effects of a preventive cardiology curriculum on behavioral cardiovascular risk factors and knowledge of medical students.

We evaluated a Preventive Cardiology Academic Award (PCAA) program designed to integrate preventive cardiology concepts into the medical school curriculum. Diet, preventive cardiology knowledge, preventive cardiology attitudes, exercise behavior, and body mass index were compared at entrance to medical school and during the graduation year. Complete data were available on 94 students (65 men and 29 women). Similar data from students who graduated in 1987, prior to the introduction of the PCAA curriculum, served as a control. Women showed a significant enhancement in attitude towards cardiovascular disease (CVD) prevention, while both men and women significantly increased their knowledge about CVD prevention. The frequency of planned physical activity decreased significantly in both sexes and men showed a significant increase in body mass index. Men significantly reduced total calories, percent of calories from fat and saturated fat and dietary cholesterol and increased fiber intake. In women, the only significant reduction was in total calories. In comparison to the control class that did not have the program, men receiving the PCAA curriculum reduced dietary cholesterol, dietary fat, saturated fat and monounsaturated fat. Changes in these dietary parameters were nonsignificant for women in comparison to the control class women. Additional analyses showed no systematic secular trends in dietary or other variables in classes entering from 1986 to 1990. We conclude that the PCAA curriculum changes have favorably affected the preventive cardiology knowledge, attitudes and diet of medical students.

Adult↗
PubMed1993

Application of a general health policy model in the American health care crisis.

There is near consensus that the US health care system requires reform. Only a quarter of the American public has faith in the current system. Health care was one of the major issues considered in the 1992 US presidential election and the search for innovative solutions has transcended administrations.

Delivery of Health Care↗
PubMed1993

Quality of life assessment: understanding its use as an outcome measure.

The limited available evidence of the effectiveness of many existing and emerging medical practices has led to the realization that health outcome data should be used in the evaluation of health care interventions. Interest in improving health outcome evaluation is increasing as a result of the need to balance the costs and benefits of medical technologies. Measures of health-related quality of life are receiving greater use in clinical studies. Quality of life measurement provides additional data for making clinical and health care policy decisions. In addition, there is growing awareness that in certain diseases, quality of life may be the most important health outcome to consider in assessing treatment efficacy. There are a number of methodological issues that must be considered in conducting or evaluating quality of life research.

Health Services Research↗
PubMed1992

Effects of offering advance directives on medical treatments and costs.

OBJECTIVE: To examine the effects of advance directives on medical treatments and on patient satisfaction and well-being and to determine whether the enhancement of patient autonomy through advance directives provides a more ethically feasible approach to cost control than does the imposition of limits through rationing. DESIGN: Randomized, controlled trial. SETTING: University and Veterans Affairs medical center. PATIENTS: Two hundred and four patients with life-threatening illnesses, 100 of whom died after enrollment in the study. INTERVENTION: Patients randomly assigned to the experimental group were offered the California Durable Power of Attorney (a typical proxy-instruction directive), and patients assigned to the control group were not offered the advance directive. Hospital admissions were monitored to assure that a summary of the document was present in the active medical record at each hospitalization. MEASUREMENTS: Cognitive function, patient satisfaction, psychological well-being, health locus of control, sense of coherence, health-related quality of life, receipt of medical treatments, and medical treatment charges. RESULTS: No significant differences were found between advance-directive and control groups regarding psychosocial variables, health outcome variables, and medical treatments or charges. Patients offered an advance directive had an average hospital stay of 40.8 days (95% CI, 32.2 to 49.4 days), compared with an average of 33.1 days (95% CI, 26.0 to 40.2 days) for controls. Patients offered an advance directive were charged an average of $19,502 (95% CI, $13,030 to $25,974) for medical treatments in the last month of life compared with $19,700 (95% CI, $13,704 to $25,696) for controls. CONCLUSIONS: Despite claims that public demand for longer life accounts for rising medical costs, most surveys suggest that patients are calling for less, not more, of the expensive, high-technology treatment often used in terminal phases of illness. Executing the California Durable Power of Attorney for Health Care and having a summary copy placed in the patient's medical record had no significant positive or negative effect on a patient's well-being, health status, medical treatments, or medical treatment charges.

Advance Directives↗
PubMed1992

Quality of life and policy analysis in arthritis.

Problems in the American health care system have stimulated interest in cost-effectiveness methodologies. However, there is little consensus on how to define a common unit of health outcome. Many measures used in policy studies consider only mortality and do not fully capture the significant impact of disease-related dysfunction. The impact of conditions, such as osteoarthritis, that have little impact on mortality rates but substantial impact on functioning and well-being may be underestimated in these analyses. In this article, we propose a measurement and policy model that is based on a theoretical conceptualization of health outcome. The model considers the impact of disease and its treatment in terms of both morbidity and mortality. The value of the model for clinical trials, population assessments, and policy analysis is reviewed. A public policy application of the model in Oregon is briefly described.

Arthritis↗
PubMed1992

One-year evaluation of cognitive-behavioral intervention in osteoarthritis.

We compared a cognitive-behavior modification and a traditional education intervention for adults with osteoarthritis (OA). Forty OA patients were randomly assigned to one of two groups: cognitive-behavior modification or didactic lectures. During ten weekly sessions, the cognitive-behavior group learned methods for coping with pain and the disabilities associated with OA. The traditional education group experienced a series of lectures from health care professionals. Prior to the interventions and following 2, 6, and 12 months, patients in both groups were evaluated with a general Quality of Well-being (QWB) scale, the Arthritis Impact Measurement Scales (AIMS), the Beck Depression Inventory (BDI), and other measures. Although there were some differences between the two groups at 2-month follow-up, by the end of 1 year, physical and psychological functioning did not differ significantly between the two groups. In comparison to baseline, both groups demonstrated initial changes on QWB, depression, and the pain component of the AIMS. Improvements in depression remained through the 1-year follow-up. Multiple regression analysis demonstrated that the mobility and physical activity aspects of the AIMS were significant long-term predictors of outcome (1 year) for general quality-of-life measures. One-year outcomes for depression were significantly predicted from scores on social support and mobility measures from the AIMS. We conclude that cognitive-behavior modification and education produce similar effects on long-term physical and psychological functioning in OA patients.

Activities of Daily Living↗
PubMed1992

Cigarette smoking, mortality, institutional and community-based care utilization in an adult community.

We evaluated mortality and health services utilization in a prospective study of 630 older residents of a Southern California community. All participants were 65 years or older when initially evaluated in 1973-1975. In addition to being followed for vital status each year, participants were reinterviewed in 1984-1986 and asked about nursing home, hospital, and community-based care for the interim period. Current cigarette use in 1973-1975 was a significant predictor of mortality for both men and women. In addition, former smoking status (before 1973-1975) significantly predicted both mortality and hospital inpatient utilization in men and women combined. However, smoking was not significantly associated with nursing home utilization or use of three categories of community-based care services. More research is necessary to identify the relationship between cigarette smoking and outpatient service use. The findings for mortality and inpatient hospital service utilization reaffirm the hazards of cigarette smoking.

Adult↗
PubMed1992

Does a reduced fat diet cause retardation in child growth?

BACKGROUND: A diet low in saturated fat and cholesterol is strongly recommended by the American Heart Association and the National Cholesterol Education Program as a way to prevent coronary heart disease. In addition, the National Cancer Institute has suggested that dietary fat restriction may also prevent the development of some cancers. However, the American Academy of Pediatrics reviewed the same evidence in relation to children and concluded that that major dietary changes recommended for adults should not be prescribed for children. METHODS: In this article, we review the evidence for the detrimental consequences associated with dietary fat restriction for children. Evidence from studies on secular trends, migration, and vegetarian communities suggests minor effects of dietary fat restriction upon growth. In addition, there is some evidence indicating that children who are placed on severe dietary restriction during growth periods may experience growth stunting. Virtually all of the published studies have serious methodological limitations. CONCLUSION: We conclude that dietary fat restriction may have some small, but measurable, effects upon growth.

Adolescent↗
PubMed1992

Functional status as an overall measure of health in adults with cystic fibrosis: further validation of a generic health measure.

We studied the validity of a generic health measure in a population with a chronic, life-shortening illness. Thirty-seven adults with cystic fibrosis (CF) and 46 of their healthy peers completed a questionnaire which included 12 questions on functional status from the RAND Health Insurance Study. For the CF group, the questionnaire and a medical chart review yielded data on 7 additional health variables, including pulmonary function. After data collection, members of the CF group were followed for 5 years, by which time 11 had died. The functional status of the CF group was significantly lower than that of the comparison group. Within the CF group, functional status correlated significantly with 6 of the 7 other health variables. Analysis using the Cox proportional hazards model showed that functional status alone was a significant (p less than 0.001) predictor of a CF subject's survival time; in a multivariate model a non-significant trend suggested that lowered functional status may be associated with an increased risk of early death even after adjustment for pulmonary function and percent ideal body weight. These results extend previous findings and suggest that functional status can be used as an overall measure of health in a wide variety of studies.

Activities of Daily Living↗
PubMed1992

Effect of posture on arterial oxygenation in patients with chronic obstructive pulmonary disease.

We studied 117 patients with chronic obstructive pulmonary disease (COPD) to evaluate (1) the frequency and magnitude of postural changes in resting arterial oxygenation and (2) the relationship of these changes to other measures of pulmonary function and exercise arterial blood gases. Compared to the supine measurement, room air PaO2 measured while standing increased more than 3 mm Hg in 28 patients (group 1), did not change (+/- 3 mm Hg) in 57 patients (group 2), and decreased more than 3 mm Hg in 32 patients (group 3) (range = 31 mm Hg increase to 20 mm Hg decrease). Patients in group 1 had significantly less severe disease than patients in the other two groups. There were no significant pulmonary function differences between groups 2 and 3. Supine PaO2 was similar for all groups, suggesting that standing PaO2 accounted for the postural change in PaO2. Because of unpredictable postural changes in PaO2 in patients with COPD, we believe that body position should be noted for arterial blood gas measurements and should be kept constant for valid comparison of serial measurements. These findings may also be important for other diffuse lung diseases.

Arteries↗
PubMed1992

Fear of dying and HIV infection vs hepatitis B infection.

Accidental exposure to the blood of hepatitis B patients produced less fear than does accidental exposure today to the human immunodeficiency virus (HIV), even though both have an approximately equal overall risk of death (approximately 1%). Subjects responding to hypothetical insect-exposure and disease-exposure scenarios chose to avoid the HIV-type risk of 1% chance of exposure/100% chance of death. Fear of certain death seems to account for the greater concern about exposure to HIV than to Hepatitis B.

Acquired Immunodeficiency Syndrome↗
PubMed1992

Relationship of general advance directive instructions to specific life-sustaining treatment preferences in patients with serious illness.

OBJECTIVE: To determine whether brief general instructions in a typical proxy-instruction advance directive (California Durable Power of Attorney for Health Care [DPAHC]) provide interpretable information about patient requests to limit life-saving treatments, and to determine whether patient treatment preferences are stable over time. DESIGN: Prospective structured interviews. SETTING: University of California, San Diego Medical Center and Veterans Affairs Medical Center, La Jolla. PATIENTS: One hundred four patients (from a randomly chosen sample of 185) with a 5-year life expectancy of no better than 50% as judged by their physicians. MAIN OUTCOME MEASURES: Patients completed the California DPAHC, a proxy-instruction advance directive, at entry and at 1 year. The patients also completed a questionnaire at entry, after 6 months, and after 1 year, indicating their preferences on a five-point Likert-format comparative rating scale for cardiopulmonary resuscitation, mechanical ventilation, artificial nutrition, and hospitalization for pneumonia. RESULTS: Sixty-eight percent of the subjects executed the DPAHC. Most patients wished treatments to be limited or withheld under certain conditions of reduced quality of life. Although general instructions noted on the DPAHC and preferences regarding specific procedures were stable over the course of a year, the advance directive's general instructions were often inconsistent with, and poor predictors of, specific procedure preferences. CONCLUSIONS: The brief general instruction component of the California DPAHC is not helpful in communicating patient wishes regarding specific life-saving procedures.

Advance Directives↗
PubMed1991

Physical activity, physical fitness, and psychological characteristics of medical students.

Exercise habits, cardiovascular fitness, and selected psychological characteristics were assessed in a sample of over 200 men and women at entrance to medical school. Fitness was measured with a step test, and other variables were measured with standardized questionnaires. Anger ('anger-in') showed the strongest negative correlation with both exercise and fitness. Anger suppression, Type A behavior, and daily stress showed significant negative correlations with both exercise and fitness variables, although the strengths of these associations were uniformly weak. Associations of exercise/fitness with depression and total anger inventory were nonsignificant. Few gender differences were found. Both exercise and fitness showed similar patterns of association with psychological variables. Both exercise and fitness were associated with a style of anger expression that has been found to be related to cardiovascular risk in other studies.

Adaptation, Psychological↗
PubMed1991

Use of factor analysis to consolidate multiple outcome measures in chronic obstructive pulmonary disease.

Multiple outcome measures are often used in clinical research and practice. However, the use of multiple measures inflates the probability of a type I error. In this paper, we used factor analysis techniques to reduce multiple outcome measures to a lesser number of orthogonal dimensions. The data were obtained from 119 patients with chronic obstructive pulmonary disease. Each patient had measurements made of 28 variables, including multiple parameters of pulmonary function, exercise tolerance and gas exchange. Factor analysis using a maximum likelihood iterative solution was performed. The factors were then rotated to a varimax solution. The analysis yielded four meaningful factors: exercise tolerance, disease severity, lung volumes and flow rates. Exercise tolerance and disease severity were the most important factors accounting, respectively, for 44 and 13% of the common variance. For further analyses, these composite factors could be used or a representative clinical measure from each factor might be chosen. We conclude that many physiologic measures provide highly correlated information about chronic obstructive pulmonary disease patients. Factor analysis may help reduce these measures into a smaller number of reliable composites.

Aged↗