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Biomedical subjects

R M Hurley

Publications and source records attributed to R M Hurley.

At least 55 records · Page 3Linked to original sources
PubMed1984

Accidental carbon monoxide poisoning.

In this case report of an accidental automobile carbon monoxide poisoning, we identify the following risk factors: freezing temperature, young passenger age, location in the rear of the auto, smaller patient mass, and auto disrepair. The pathogenesis of carbon monoxide poisoning is reviewed. Emergency treatment and suggested criteria for hyperbaric oxygen use in pediatric patients are discussed.

Accident Prevention↗
PubMed1984

Anaphylaxis during hemodialysis.

A ten year old boy with renal failure secondary to the branchio-oto-renal syndrome had a severe anaphylactic reaction during his first hemodialysis. The allergen implicated in the reaction was ethylene oxide gas used for dialyzer sterilization. RAST testing done just after anaphylaxis may be falsely negative and thereby misleading.

Anaphylaxis↗
PubMed1982

A preliminary report on three 40-word revised CID W-22 lists of equal difficulty.

Normal-hearing young adults (N: 24) yielded normative speech recognition data at 6 SLs from 4-24 db on each of 3 experimental lists of 40 words each, taken from the 120 most difficult words in the CID W-22 word pool (Campbell, 1965). Tapes were recorded by a male talker who independently produced each of 4 scramblings of each list. There were no significant differences among the scramblings of each list. With the scramblings collapsed across SL, the 3 lists were shown equivalent, with a performance-intensity function slope through its linear portion of 3.8%/db.

Adult↗
PubMed1982

The effect of training on discrimination of vibrotactual speech stimuli.

Normal-hearing young adults (N: 30) discriminated CVs and vowels vibrotactually presented by a vibrator of the hearing-aid type. Features of voicing, place and manner could be discriminated above chance levels when contrasted with the same phoneme class. Discrimination of vowels, however, was at chance level. Although a brief (10-hr) training curriculum did not significantly increase vibrotactile discrimination of either CVs or vowels, such a vibrator could be used to supplement the acquisition of articulation in the severely and profoundly hearing-impaired person.

Adult↗
PubMed1981

Renal disease-a sixth cardinal feature of the Laurence-Moon-Biedl syndrome.

A 39 year old man with 4 of the 5 cardinal features of the Laurence-Moon-Biedl syndrome (LMBS) had proteinuria and moderate renal failure. Excretory urography showed small cysts communicating with the dilated calyceal system. Renal biopsy showed diffuse mesangial sclerosis and cellular proliferation. Excretory urograms in 22 of 24 reported patients demonstrated similar findings. Review of renal pathology reports on 16 patients revealed either chronic glomerulonephritis or severe tubulo-interstitial disease with cysts or both in 8 of 9 who died from uremia and 2 of 7 who died from other causes. The abnormalities seen on excretory urography occur more frequently than 2 of the cardinal features, and as uremia is often the cause of death for these patients, renal disease should be considered a cardinal feature of LMBS.

Adult↗
PubMed1979

Methylmalonic acidemia: 6 years' clinical experience with two variants unresponsive to vitamin B12 therapy.

Two infants with lethargy, vomiting, convulsions, coma and marked metabolic acidosis were found to have very high concentrations of methylmalonic acid in their serum and urine. In vitro studies of fibroblasts demonstrated that the infants had different variants of methylmalonic acidemia.Vitamin B(12) was given in two different forms at 1 month of age and at 12 months of age. Each trial continued for 4 months but neither infant showed a clinical or biochemical response.In both infants hyperglycinemia, neutropenia and thrombocytopenia developed during acute metabolic crises only. Hypoglycemia was found in patient 2. Hyperammonemia was severe in patient 2 during acute crises but never appeared in patient 1. When clinically well, both infants continued to excrete abnormal amounts of methylmalonic acid in the urine and both had persistent compensated metabolic acidosis.Marked hyperuricemia developed in patient 1 at 18 months of age and led to progressive renal failure. Allopurinol therapy was necessary to keep the uric acid concentration within the normal range. Renal function returned to normal, as indicated by a marked increase in the renal clearance of creatinine and uric acid.Patient 1 is physically and mentally retarded, and has moderate hypotonia, hepatomegaly and persistent vomiting. Patient 2 has developed normally.The urine concentrations of methylmalonic acid in the four parents were normal.

Amino Acid Metabolism, Inborn Errors↗
PubMed1977

Treatment of recurrent syndrome of inappropriate secretion of antidiuretic hormone with lithium.

The usual treatment for recurrent syndrome of inappropriate secretion of antidiuretic hormone has been fluid restriction. Recently White and Fetner described an adult with SIADH successfully managed with lithium carbonate. Described here is a child with recurrent SIADH who was diagnosed as having an acute hyponatremic episode and who then relapsed twice in a two-month period while chronic fluid restriction was attempted. He has now been maintained on 300 mg/day of lithium carbonate and is asymptomatic with normal serum sodium concentration and urine osmolalities. Lithium appears to be effective in the management of recurrent SIADH and may allow control in a patient who cannot comply with long-term fluid restriction.

Child↗