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Biomedical subjects

R M Fusaro

Publications and source records attributed to R M Fusaro.

At least 55 records · Page 3Linked to original sources
PubMed1991

Pancreatic cancer and the familial atypical multiple mole melanoma (FAMMM) syndrome.

The role of host factors in the etiology of pancreatic cancer has received a paucity of systematic investigation. Anecdotal reports and one population-based study have supported the concept that familial clustering of this disease exists. We have studied a kindred with a cancer-associated genodermatosis known as familial atypical multiple mole melanoma (FAMMM) syndrome (hereditary dysplastic nervus syndrome). Three key relatives have manifested pancreatic carcinoma. Since FAMMM may account for as much as 10% of the total malignant melanoma burden, its association with pancreatic cancer harbors important public health implications. Given the fact that the etiology of pancreatic cancer remains enigmatic, it is important to investigate all possible clues to its causality, including the potential role of host factors.

Adult↗
PubMed1991

Mucinous cysts of the vulva.

Two cases of mucinous cysts of the vulva are reported. The embryology of the lower female genital tract is described, including the Müllerian duct system, cloaca and urogenital sinus. The relationship of the Wolffian duct system is also included in the discussion. It has been felt in the past that these vulvar cysts are Müllerian-derived. However, it is now deemed more plausible that they are from the entodermally-derived urogenital sinus epithelium. These cysts pose no threat to the patient but are interesting from the standpoint of embryogenesis.

Adult↗
PubMed1990

Systemic cancer and the FAMMM syndrome.

The FAMMM syndrome consists of the familial occurrence of cutaneous malignant melanoma and atypical nevi (dysplastic nevi), and is inherited as an autosomal dominant trait. Conflicting results have been reported on the question of whether the syndrome includes increased susceptibility to non-melanoma cancers. We have studied cancer of all anatomic sites and histologies in nine FAMMM families which were ascertained in a pigmented lesions clinic in the Netherlands. We evaluated two hypotheses: that the number of systemic cancers observed in the families was excessive, compared to expected incidence, based on Dutch incidence data, and that there was variation (or heterogeneity) among families in the frequency of systemic cancer. A significant excess of systemic cancer (especially digestive tract cancer) was observed. Significant heterogeneity was also found among the families; three of the nine families had marked excess in numbers of systemic cancers, and the remaining families had normal numbers of cancers among the known FAMMM gene carriers and their first degree relatives. Thus, we provide evidence of increased susceptibility to systemic cancer occurring in conjunction with the FAMMM syndrome in a subset of this resource.

Adult↗
PubMed1988

Flexible classification for the clinical potency of topical corticosteroid proprietaries.

A flexible system of classifying topical corticosteroid proprietaries is proposed to help the clinician understand the relative antiinflammatory potency of these products. This system has the advantage of indicating not only the relative potency of a specific proprietary preparation but also noting the number of divisions in the classification. It allows for new product development and keeps the clinician informed of the change by the number of divisions being used. The system also has the potential for the classification of relative severity of both local and systemic side effects of corticosteroids.

Administration, Topical↗
PubMed1988

Some unusual periorbital dermatoses.

Three case reports of primary periorbital dermatitis are presented. The etiology of these were molluscum contagiosum, Microsporum canis, and Coccidioides immitis. In each case, the presenting complaint was unusual since the primary lesion started in the periorbital region.

Adult↗
PubMed1987

Protection of photosensitized rats against long ultraviolet radiation by topical application of compounds with structures similar to that of dihydroxyacetone.

Dihydroxyacetone (DHA), a browning agent, protects photosensitive rats and humans against long ultraviolet radiation (UVA, 320-400 nm) and visible (blue) light. The photoprotective efficacy of DHA and structurally similar compounds was assessed as prevention of edema in the paws of psoralen-sensitized rats, after exposure to blacklight fluorescent lamps. Methylglyoxal produced a yellow-brown color and provided nearly the same protection as DHA, whereas monohydroxyacetone did not color the skin and afforded little or no protection. Glyceraldehyde provided a moderate amount of protection, which was enhanced by prior exposure of the agent to alkaline pH. A solution of 5-hydroxymethylfurfuraldehyde was yellow and provided minimal protection by staining the skin rather than browning it. We conclude that the ability to produce a brown color in skin is a useful criterion for screening compounds for photoprotective efficacy against UVA radiation.

Aldehydes↗
PubMed1986

Hereditary malignant melanoma: a unifying etiologic hypothesis.

The recent increase in incidence of malignant melanoma in many of the "sun belts" of the world has focused intense interest on its etiology. Although sunlight is an important factor, only a fraction of those individuals exposed to significantly large amounts of sunlight develop malignant melanoma. Genetic susceptibility undoubtedly plays an important etiologic role. We have put forth a multifaceted hypothesis, which we believe provides unification for the genetic-environmental interaction in the etiology of malignant melanoma. Genetic heterogeneity in the familial atypical multiple mole melanoma (FAMMM) syndrome and other single gene disorders that predispose to malignant melanoma are particularly stressed. The possibility of polygenic or multifactorial factors in the etiology of malignant melanoma remains to be elucidated.

Albinism↗