Biomedical subjects

R M Freeman

Publications and source records attributed to R M Freeman.

At least 73 records · Page 4Linked to original sources

PubMed1976

Serum levels of a component reacting with antiserum to urinary antitrypsin in health and disease with emphasis on high levels in renal failure.

A component in serum reacting immunologically to form a precipitate with an antiserum to purified urinary trypsin inhibitor (CRAUTI) was measured by radial immunodiffusion. CRAUTI was demonstrated in the sera of 94 normal subjects and 350 patients with a variety of illnesses. With few exceptions it was increased only in patients with renal disease. The amount of CRAUTI increased as glomerular filtration rate decreased and returned to normal promptly after successful renal transplantation. CRAUTI was nondialyzable. CRAUTI is immunologically related to but not identical with inter-alpha-trypsin inhibitor.

Adolescent↗

PubMed1975

Zinc metabolism in aminonucleoside-induced nephrosis.

Nephrosis was induced in Sprague-Dawley rats in two separate studies by injections of aminonucleoside with sacrifice of animals on days 20 and 54, respectively. Experimental animals in both studies showed the typical findings of nephrosis, i.e., hypoalbuminemia, hypercholesterolemia, and proteinuria. Biochemical findings included hypozincemia and hyperzincuria. A significant correlation between hypozincemia and hypoalbuminemia was noted in the short-term study. Proteinuria occurred on the 10th day in the short-term study and the 15th day in the long-term study and increased quantitatively over the remaining days. The hyperzincuria and proteinuria correlated significantly in the long-term study. Measurements of tissue zinc revealed no change in testes and kidney in the short-term study. Kidney and muscle zinc were increased, testicular zinc was unchanged and femur zinc was decreased in the long-term study. Our conclusions are that in the aminonucleoside induced nephrosis of the rat: 1) hypozincemia occurs probably as a result of hypoalbuminemia, 2) the hyperzincuria is likely due to proteinuria and 3) zinc deficiency is not observed in nephrotic rats who receive ample zinc in their diet and who are observed up to 6 weeks.

Animals↗

PubMed1973