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Biomedical subjects

R M Craig

Publications and source records attributed to R M Craig.

At least 73 records · Page 4Linked to original sources
PubMed1983

Kinetic analysis of D-xylose absorption in normal subjects and in patients with chronic renal failure.

D-Xylose kinetics were studied in 12 normal subjects and in nine patients with chronic renal failure requiring dialysis (five hemodialysis and four peritoneal dialysis). None of the study subjects had demonstrable gastrointestinal disease. Doses of D-xylose were given intravenously (10 gm) and orally (25 gm) on different nondialysis days in order to determine the distribution and elimination kinetics and the absolute bioavailability of this compound. Our findings were as follows. (1) The nonrenal clearance of D-xylose is markedly reduced in chronic renal failure patients (43.3 vs. 90.9 ml/min, p less than 0.002). (2) D-Xylose is less completely absorbed in patients with chronic renal failure than in normal subjects (48.6% vs. 69.4%, p less than 0.01). (3) The absorption rate of D-xylose is slower in these patients than in normal subjects (0.555 hr-1 vs. 1.03 hr-1, p less than 0.05). (4) The absorption rate is positively correlated with the extent of D-xylose absorption (r = 0.49, p = 0.03). (5) Although peak D-xylose concentrations measured 1 hr after oral administration are well correlated with the extent of D-xylose absorption in normal subjects and in functionally anephric patients (r = 0.59, p less than 0.01), formal kinetic study is required to determine D-xylose bioavailability precisely because of the large variability in peak serum D-xylose concentrations and in the time required to reach these peak concentrations.

Adult↗
PubMed1982

Intense nutritional support in inflammatory bowel disease: a review.

We have reviewed the value of intense nutritional support in inflammatory bowel disease (IBD), relying mostly on the limited uncontrolled studies that have been performed. In most circumstances, nutritional restitution and a short-term clinical remission are accomplished when this support is provided. In some patients, particularly those with Crohn's disease who undergo surgery, intense nutritional support probably decreases morbidity and mortality. Children with IBD can undergo linear growth rates with nutritional supplementation. There is a great need for additional controlled studies.

Colitis, Ulcerative↗
PubMed1982

Unusual causes of spontaneous pneumoperitoneum.

Spontaneous pneumoperitoneum may pose a diagnostic dilemma, especially when evaluating a patient who has no or minimal abdominal or constitutional findings accompanying its presence. The free intraperitoneal air may be the result of a perforation of a hollow viscus in such instances. Under these circumstances, the air is most often from another source. The more common sites of origin are intrathoracic sites, air in the wall of the intestinal tract and the genital organs in women. Diagnostic and therapeutic procedures in or adjacent to the abdomen may result in an iatrogenic pneumoperitoneum. In each instance when the findings of an acute abdominal catastrophe are lacking, the circumstances present before the discovery of the pneumoperitoneum should give a clue to the appropriate diagnosis. When a reasonable nonsurgical cause can be discerned, continued observation may be sufficient, thus avoiding an unnecessary laparotomy.

Abdomen↗
PubMed1981

Intraoperative angiography in intestinal angiodysplasia.

Intraoperative angiography is quite useful in locating the site of bleeding in patients with angiodysplasia of the small intestine. We recommend the placement preoperatively of an angiographic catheter in these patients. We have described a technique that complements this procedure with metallic clip labeling to locate precisely the area of bleeding. This method of treatment is illustrated in the present study by reports of patients bleeding from vascular malformations of the ileum, duodenum and the head of the pancreas.

Aged↗
PubMed1980

Irregular papular lesions of the hard palate.

Dental practitioners should be familiar with Darier's disease because oral lesions of the disease may resemble other diseases. Differential diagnosis should include papillary hyperplasia of the palate, acanthosis nigricans, Cowden's disease, nicotine stomatitis, and condyloma acuminatum. Careful observation of the oral and skin lesions and consideration of the medical and family history should assist in diagnosis. Vitamin A, given in high doses, has been used with variable success in the treatment of Darier's disease. Systemic corticosteroids have been used with good results, but these require prolonged use as they are not curative. Secondary infection is a common complication for which topical corticosteroids are helpful.

Adult↗
PubMed1980

Acute episodic inflammatory lesions of the mucous membrane and skin.

The first consideration in the treatment of erythema multiforme is to search for and eliminate a possible underlying cause. Mild cases require little treatment. Severe forms of the disease must receive prompt, active therapeutic measures. Fluid and electrolyte imbalance must be corrected, secondary bacterial infections must be combated with topical or systemic antibiotics, and large doses of systemic corticosteroids are used for short periods. Without treatment, lesions can persist for many weeks. Mild forms of the disease, which constitute most of the cases, usually subside in a few days to two to three weeks without sequelae. Severe forms persist for three to six weeks longer; sequelae include neurologic changes, corneal opacities, blindness, conjunctival, vaginal, or preputial synechiae, and esophageal strictures. Mortality of all forms has been reported as less than 0.5% but severe cases, at approximately 10%. Recurrences are likely in approximately 25% of the cases; the pattern is variable, chronic, and episodic.

Adult↗
PubMed1980

Asymptomatic multilocular radiolucent lesion of the mandible.

The odontogenic keratocyst is an established pathologic entity. Dentists must be aware of its existence and understand its clinical characteristics. Because it is impossible to radiographically and clinically differentiate the keratocyst from more innocuous odontogenic cysts, all cystic lesions removed from patients should be submitted for histopathologic examination and diagnosis.

Adult↗
PubMed1980

Severe hepatocellular reaction resembling alcoholic hepatitis with cirrhosis after massive small bowel resection and prolonged total parenteral nutrition.

A middle-aged man is described who developed a severe liver disease resembling alcoholic hepatitis which occurred after prolonged total parenteral nutrition for a severe short bowel syndrome. His nutrition was well maintained in terms of biochemical parameters, suggesting that the liver disease was not mediated by a nutritional deficit.

Fatty Acids, Essential↗