Search PubMed⌕ Search

Biomedical subjects

R M Browne

Publications and source records attributed to R M Browne.

At least 109 records · Page 6Linked to original sources
PubMed1977

Autofluorescent granular cells in oral mucosal hyperplasias.

Four hyperplastic lesions of the hard palate are described. They were characterized by the presence of an atrophic surface epithelium, an oedematous matrix and the presence of large numbers of autofluorescent granular cells. In addition there were numerous mast cells. Histochemical and electronmicroscopical studies suggest that the granules are composed of lipofuscin. The pathogenesis of these lesions is discussed.

Aged↗
PubMed1977

Etiological factors in oral squamous cell carcinoma.

A retrospective survey of 75 patients with oral squamous cell carcinoma (ICD Nos. 143, 144, 145) resident in the County Borough of Stoke-on-Trent, England, and 150 controls has been carried out by interview. The controls were matched for age, sex, occupation and place of residence. There was no difference in the prevalence or duration of denture wearing, although male controls had their dentures remade more frequently. Male patients practised oral hygiene procedures less frequently when they had their own teeth than controls. Habitual beer-drinking was more common and greater quantities were drunk by male patients than controls. Habitual cigarette smoking was less and pipe smoking greater among male patients than controls. Tobacco chewing, which was restricted to miners, was equally common (45%) in the two groups. Among miners, the combined habit of tobacco chewing and pipe smoking was more common among patients (1005) than among controls (25%).

Adult↗
PubMed1976

Some observations on the fluids of odontogenic cysts.

The fluids of 44 dental cysts, 19 dentigerous cysts, 36 odontogenic keratocysts, and 12 ameloblastomas have been investigated. The incidence of epithelial cells, inflammatory cells, cholesterol crystals and bacteria was recorded in smears. There was a high incidence of epithelial cells in odontogenic keratocysts and not in other lesions. Cholesterol crystals had a similar incidence in all lesions. The proportion of the soluble proteins and total protein content was determined from cellulose acetate electrophoresis. Dental cysts contained an average of 51.19% albumin, 17.52% beta globulin, 22.04 % gamma globulin, and 6.30 g/100 ml protein. Dentigerous cysts contained an average of 61.35% albumin, 13.98% beta globulin, 12.70% gamma globulin and 5.40 g/100 ml protein. Odontogenic keratocysts contained an average of 78.03% albumin, 7.51% beta globulin, 7.91% gamma globulin, and 2.09 g/100 ml protein. Ameloblastomas contained an average of 67.38% albumin, 12.83% beta globulin, 12.60% gamma globulin and 4.86 g/100 ml protein. The immunoglobulin content was determined by single radial immunodiffusion. Dental cysts contained an average of 488.9 mg/100 ml IgA, 2535.4 mg/100 ml IgG, and 135.6 mg/100 ml IgM. Dentigerous cysts contained an average of 308.4 mg/100 ml IgA, 1618.2 mg/100 ml IgG, and 155.6 mg/100 ml IgM. Odontogenic keratocysts contained an average of 135.6 mg/100 ml IgA, 491.9 mg/100 ml IgG, and 54.1 mg/100 ml IgM. The significance of these findings in the pathogenesis and diagnosis of these lesions is discussed.

Albumins↗
PubMed1976

Reprecipitation phenomena arising during the preparation of demineralised sections. III Scanning electron microscopic examinations of secondary calcium phosphate deposits.

Sections of teeth partly demineralized in 10% formic acid were examined by X-ray diffraction, microradiography and scanning electron microscopy. In the undemineralized circumpulpal dentin, the tubules were empty, lying in a matrix containing hydroxyapatite. In the "plume" areas of remineralisation, the tubules were filled with mineral deposits. X-ray diffraction revealed the presence of brushite and monetite in these areas. In the outer layers of dentin the tubules were empty, lying in a matrix containing some residual hydroxyapatite. These findings confirmed that the remineralisation process occurred within the dentinal tubules.

Calcium Phosphates↗
PubMed1975

The pathogenesis of odontogenic cysts: a review.

The pathogenesis of the three common forms of odontogenic cyst is discussed. It is concluded that the dental cyst arises from proliferation of the epithelial rests of Malassez in a focus of inflammation stimulated by pulpal necrosis of the associated tooth. It enlarges by unicentric expansion from the hydrostatis pressure of its contents. The dentigerous cyst arises from pooling of inflammatory exudate, which is derived from the obstructed follicular veins of an unerupted tooth and accumulates between the reduced enamel epithelium and the crown of the tooth. It enlarges by unicentric expansion from the hydrostatic pressure of its contents. The odontogenic keratocyst arises by proliferation of the residues of the dental lamina, possibly as a hamartomatous abnormality. It enlarges by both multicentric expansion due to the proliferation of localized groups of epithelial cells in the lining and by unicentric expansion from the hydrostatic pressure of its contents.

Autoradiography↗
PubMed1975

Reprecipitation during the preparation of demineralized sections. II. Experimental observations.

Teeth were incompletely demineralized by immersion in unchanged 10% formic acid for 7 days. Reprecipitation deposits of secondary calcium phosphate were present in the dentin and soft tissues of the dental pulp and, if the final pH was 3 or greater, in the remnants of the periodontal ligament. The deposits in the dentin appeared to be intratubular. Deminieralized sections of teeth suspended in supersaturated solutions of brushite contained similar deposits in the soft tissues. It is suggested that reprecipitation of secondary calcium phosphates is a frequent intermediate stage during demineralization with formic acid.

Acids↗
PubMed1974

Tissue reactions to two fissure sealant resina.

Specimens of polymerized and unpolymerized Nuva-Seal and Alpha-Seal were implanted subcutaneously on polythene rods. Polymerized specimens caused only slightly greater reaction than controls over intervals of from 2 days to 1 year. Unpolymerized specimens caused necrosis, marked inflammatory cell infiltration and granulation tissue formation for up to 1 week but were similar to the controls at 1 year. No reaction to unpolymerized resin painted on the oral mucosa was observed.

Animals↗