Biomedical subjects

R M Bowley

Publications and source records attributed to R M Bowley.

5 recordsLinked to original sources

PubMed2004

Are Brazil nuts attractive?

We present event-driven simulation results for single and multiple intruders in a vertically vibrated granular bed. Under our vibratory conditions, the mean vertical position of a single intruder is governed primarily by a buoyancylike effect. Multiple intruders also exhibit buoyancy governed behavior; however, multiple neutrally buoyant intruders cluster spontaneously and undergo horizontal segregation. These effects can be understood by considering the dynamics of two neutrally buoyant intruders. We have measured an attractive force between such intruders which has a range of five intruder diameters, and we provide a mechanistic explanation for the origins of this force.

Journal Article↗

PubMed2003

Controlled E-field gradient coils.

Peripheral neural stimulation is a major problem in current gradient coil designs. Induced current problems in patients relate directly to gradient strength and modulation frequency. Current designs of gradient coil tend to limit ultra-high-speed imaging methods such as echo-planar imaging through the effect of induced currents which produce tingling sensations and involuntary muscle twitch. Neural stimulation could also trigger epileptic fits and/or cardiac fibrillation. For reduction of induced currents, an important aspect is the coil geometry. It is desirable to design the gradient coil in such a way as to prevent closed loop circulating currents within the body. Preliminary results using a four-sector gradient coil with rectangular geometry, operating in a low mutual coupling mode, indicate significant reduction in the E-field within the subject volume of the coil. Reduction in induced currents in the patient allows safer operation at higher magnetic field strengths together with faster scans currently prohibited through neural stimulation effects in standard coil geometries.

Computer Simulation↗

PubMed2002

Electric fields induced in a spherical volume conductor by temporally varying magnetic field gradients.

A homogeneous spherical volume conductor is used as a model system for the purpose of calculating electric fields induced in the human head by externally applied time-varying magnetic fields. We present results for the case where magnetic field gradient coils, used in magnetic resonance imaging (MRI), form the magnetic field, and we use these data to put limits on the rates of gradient change with time needed to produce nerve stimulation. The electric field is calculated analytically for the case of ideal longitudinal and transverse linear field gradients. We also show results from computer calculations yielding the electric field maps in a sphere when the field gradients are generated by a real MRI gradient coil set. In addition, the effect of shifting the sphere within each gradient coil volume is investigated. Numerical analysis shows similar results when applied to a model human head.

Biophysical Phenomena↗

PubMed2000

Analytic calculations of the E-fields induced by time-varying magnetic fields generated by cylindrical gradient coils.

Analytic expressions which allow the direct calculation of the electric field generated inside an infinite conducting cylinder by varying the current through the wires of any cylindrical coil are presented. These expressions provide some general insight into the spatial characteristics of the electric field generated inside the body by switched gradients and can be used to evaluate the locations where nerve stimulation by rapid gradient switching is likely to occur. They may also be employed at the design stage to produce gradient coils which can provide higher gradient switching rates without causing nerve stimulation. Using these expressions the electric field patterns produced by transverse and longitudinal, whole-body gradient coils were calculated. Example data are presented along with the associated magnetic field patterns. The effect on the induced electric field pattern of varying the body size and the size of the region of gradient linearity was explored.

Body Constitution↗

PubMed1988

A general approach to selection of multiple cubic volume elements using the ISIS technique.

The ISIS method is used regularly for the selection of a single cubic volume of tissue for in vivo investigation by high-resolution NMR spectroscopy. This technique has been extended on a theoretical basis to include the simultaneous selection of a number of cubes, the signals from which can be either assessed individually or in certain circumstances coadded to produce improvement in signal-to-noise ratio. The modification requires additional selective RF pulses in the spatial encoding prepulse period, and spatially localized spectra are produced by addition and subtraction of NMR signals in a manner similar to the original ISIS technique.

Humans↗