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Biomedical subjects

R Lutz

Publications and source records attributed to R Lutz.

41 records · Page 3Linked to original sources
PubMed1981

A fast interval processor (FIP) for cervical prescreening.

A cervical prescreening device (FIP: fast interval processor) designed to scan and classify a slide-mounted specimen within two minutes is described. The image analysis techniques are based directly on the MRC Cerviscan equipment with the minimal conversion needed to adapt these techniques for interval processing. A high scanning rate is achieved by scanning with a charge-coupled diode linear image sensor along one axis and by stepping the microscope stage continuously along the other axis. High processing rates are achieved using an asynchronous pipeline approach. Operations on pixels are carried out by parallel dedicated hardware units, while operations on intervals (segments) are carrie out using a dual microprocessing configuration. A determined attempt has been made to minimize the cost of the components required. Preliminary results showing scanning and processing performance are given.

Cervix Uteri↗
PubMed1975

Benzopyranopyridine derivatives. 1. Aminoalkyl derivatives of the azaxanthenes as bronchodilating agents.

The preparation of the four isomeric azaxanthones 3 and a number of their aromatic ring substituted derivatives is described. These ketones were converted into the title compounds which were examined for their biological properties. The most interesting compound in this series, the 1-methyl-4-piperidylidene derivative of 1-azaxanthene, shows the profile of an orally effective potent bronchodilating agent as well as a moderate antihistamine. Biological properties of this compound were compared to a number of antihistamines as well as known bronchodilating agents. Structure-activity relationships are also discussed.

Airway Resistance↗
PubMedDate not supplied

Expression of the proliferation-associated Ki-67 antigen in bovine testicular tubular cells during the seminiferous epithelial cycle, demonstrated with the MIB-1 antibody.

Ki-67 expression in the seminiferous tubule of the bovine testis was studied by immunohistochemistry during the seminiferous epithelial cycle using the monoclonal antibody MIB-1. Spermatogonial proliferation is most obvious in stages 5-7, and 8, when B-spermatogonia divide. A lower rate of spermatogonial propagation is observed preceding or during meiosis in stages 1-4. The MIB-1 antibody also gives positive results with some post-spermatogonial tubular cells. Preleptotenes passing through S-phase in stage 1 reveal positive nuclei. During prophase of meiosis I pachytenes react strongly, diplotenes react in an attenuated manner, while leptotenes and zygotenes stay negative. Secondary spermatocytes seen in stage 4 are positive as are the chromosomes during meta- and anaphase of the meiotic divisions. Post-meiotic spermatids are also decorated but stop Ki-67 expression abruptly at the end of stage 4. Sertoli cells are negative.

Animals↗
PubMedDate not supplied

Spontaneous fusion in scoliosis after instrumentation without arthrodesis.

The technique of subcutaneous rod insertion without exposure of the curve has been proposed as a method of controlling the progression of scoliosis while allowing the spine to grow. We review the literature and present three patients whose spines spontaneously fused unexpectedly while undergoing this form of treatment. The fusion occurred posteriorly, and continued anterior growth led to increased deformity from the crankshaft phenomenon. Based on this experience, the authors recommend careful follow-up and early anterior fusion when the crankshaft phenomenon is observed.

Child↗