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Biomedical subjects

R Lober

Publications and source records attributed to R Lober.

At least 37 records · Page 2Linked to original sources
PubMed1994

[Sperm antibodies--a suitable parameter for diagnosis of fertility?].

Antibodies against spermatozoa specific antigens may be produced in female as well in male subjects. There is some evidence that they are able to contribute to infertility in susceptible couples. Therefore, we studied these antibodies with regard to the diagnostics of infertility. It is shown that there is no significant enhancement in the serum levels of the antibodies in infertile female patients and their partners. The figures measured are comparable to those found in pregnant or in climacteric women. It is concluded that the determination of these antibodies does not contribute to an improved diagnostic of infertility.

Adult↗
PubMed1993

[Oral methotrexate in trophoblast seeding after laparoscopically treated tubal pregnancy].

The atypical course after laparoscopic conservative treatment of tubal pregnancy is described. Routine measurements of the serum HCG levels postoperatively showed, after a short period of decreasing HCG levels, a new increase of HCG values. Under the suspicion of a disseminated intraperitoneal trophoblastic tissue the patient was treated with 20 mg methotrexate q.i.d. per os for 5 days, as a result of which HCG levels returned to normal within a short time.

Adult↗
PubMed1992

[Uterine abnormality and fallopian tube damage--surgical correction in one session?].

From 1983 to 1990 15 metroplasties were carried out at the Department of Obstetrics and Gynecology Greifswald. 11 of these operations were combined with a microsurgical tubal operation. For the diagnostics of uterus malformation and tubal damage as many methods as possible (hysterosalpingography, laparoscopy with chromotubation, hysteroscopy and sonography) should be used. A postoperative life birth rate of 62.5% shows that an operative correction of uterus malformation and tubal damage in one session is justified. Metroplasty is also indicated at primary tubal sterility with simultaneous uterus malformation. A caesarean section is not primarily indicated after metroplasty.

Abortion, Habitual↗
PubMed1991

[Microsurgical sterility operations in female patients with deficient contralateral tube--pros and cons].

Microsurgical operations of sterility on 39 women with only one remaining tube have been analysed in order to examine the justification of primary operations of sterility on these patients. 13 out of 26 women (50%), who had been followed up for at least 9 months after the operation, have become pregnant. Live birth rate was 30.8% abortion rate 7.7% and the rate of ectopic pregnancies 11.5%. The results correspond to these obtained from women bilaterally operated on, so that microsurgical operations are justified in sterile women with a lacking opposite tube, too. The removal of the opposite tube during the actual operation of sterility is prognostically more advantageous than the exstirpation before it. Salpingectomy has better results than salpingo-oophorectomy.

Abortion, Spontaneous↗
PubMed1991

[The prognostic value of pre- and postoperative adhesion score and chromopertubation score in sterility operations on the fallopian tubes. 1. Comparison of pre- and postoperative laparoscopic findings].

With 97 female patients who underwent a microsurgical operation of sterility the respectively less damaged tube has been assessed during the diagnostic laparoscopy and during the second-look-laparoscopy with the help of an adhesions-score and a chromopertubation-score. On 92 tubes only one operation was carried out, whereas on five tubes the proximate operation was combined with a distal one. After all methods of operations markedly better adhesions-scores and chromopertubations-scores were achieved. The postoperative adhesions-score was in 79.4% of all cases better than preoperative original value. The chromopertubation-score was postoperatively better in 72.2% of the tubes. 25.8% were macroscopically unobtrusive during the second-look-laparoscopy. After combined distal and proximal operations on one tube favorable postoperative laparoscopic results could be achieved, too.

Adult↗
PubMed1991

[The prognostic value of pre- and postoperative adhesion scores (AS) and chromopertubation scores (CPS) in tubal interventions for sterility. 2. Postoperative rate of conception in relation to pre- and postoperative laparoscopy findings in tubal interventions for sterility].

In 97 female patients the respectively less damaged tube has been laparoscopically assessed with the help of on adhesions-score and a chromopertubation-score. The correlation to postoperative fertility has been examined. The rate of conception of patients who underwent a laparoscopic examination was 28.8%. The live birth rate was 17.5%, the rate of spontaneous abortions was 2.1% and the rate of ectopic pregnancies 9.2%. The preoperative adhesions-score doesn't allow prognostical statements, whereas the postoperative adhesions-score closely correlated with the postoperative rate of conceptions. Female patients with a preoperative partial tubal occlusion (CPS = 1) postoperatively chances of conceptions twice as high as female patients with a preoperatively total tubal occlusion (CPS = 2). A postoperative total tubal occlusion (CPS = 2) is a primary indication for in-vitro fertilization.

Adult↗
PubMed1989

[Fertility following function-preserving operations in ectopic pregnancies--results and experiences].

Today the function-retaining operation of the ectopic pregnancy is the method of choice in adequate preconditions. After 63 tube-retaining operations 30 pregnancies (47.7%) and a live birth rate of 36.5% could be achieved. After tube-retainingly operated ectopic pregnancies the prognosis of fertility is more advantageous than after salpingectomien. Besides the risk of relapse has no been increased. The procedure and the perioperative programme is described in tube-retaining operations of ectopic pregnancy.

Fallopian Tubes↗
PubMed1988

[A rare case of cervix pregnancy].

A case of 11 week old cervical pregnancy is reported. Aetiology, pathogenesis, diagnosis and treatment of this rare case of ectopic pregnancy is discussed.

Abortion, Missed↗
PubMed1988

[Endometriosis and basal temperature].

Basal body temperature of 168 cycles have been measured in 20 infertile women (age 21-31 years) with endometriosis. There were 10.1% anovulatory cycles, and in 22.5% of the 151 biphasic cycles the hyperthermic phase lasted less than 11 days. A late decline of basal body temperature after the onset of menstruation was recorded in 34.5% and may be only limitedly indicative of endometriosis. In 64.9% of all cycles basal body temperature was somewhat elevated and/or proved one or more temperature peaks in the follicular phase. Perhaps this may be indicative of endometriosis. Nevertheless the so-called endocrinologic infertility requires endoscopy for accurate diagnosis.

Adult↗
PubMed1987

[Experiences with the use of sulprostone (Nalador) for the termination of pregnancy in the 1st trimester in primigravidae].

Sulprostone in different doses and application forms (25, 50 or 100 micrograms extra-amnionic; 500 micrograms or 3 times 500 micrograms every 4 hours intramuscularly) was given to perform termination of pregnancy between 7th and 12th week. The dose of 500 micrograms three times given was most effectiveness, but there were the most side effects, too. The dose of 500 micrograms Sulproston was accompanied by less side effects and the therapeutic success was sufficient. The extra-amnionic application was effective also in all used dosages.

Abortifacient Agents↗
PubMed1986

[Haptoglobin typing in abortion in the 1st trimester].

The type of haptoglobin was examined in 239 women suffering from hemorrhage in early pregnancy. The distribution of Hp-types in the different forms of abortion was compared with a reference group. A provable significant deviation in distribution of Hp-types could be traced in case of incomplete abortion. The immunological lower reaction capacity in haptoglobin type 1-1 has been discussed.

Abortion, Incomplete↗
PubMed1985

[Plasma fibrinogen in female patients with genital cancer and its early stage].

Changes of plasma fibrinogen derivates in 54 female patients suffering from carcinomas of the genital system (36 with cervix carcinoma, 9 with ovarian carcinomas, 7 with carcinomas of the corpus uteri, 1 woman with a vulva and 1 patient with vaginal carcinoma) and 6 females with cervical intraepithelial neoplasia were investigated. It was shown, that the fibrinogen content and the concentration of soluble fibrin monomer complexes in blood plasma depend on the extension of the clinically diagnosed tumor. Furthermore, differently degraded fibrinogens were demonstrated to exist in the blood circulation. The extent of fibrinogenolysis did not correlate with the clinically diagnosed tumor stage.

Adenocarcinoma↗
PubMed1985

[Proteolytic changes in plasma fibrinogen from ovarian venous blood in patients with cervix cancer].

From 9 female patients suffering from carcinoma cervicis (8 women with a stage Ib, 1 woman with a stage IIa carcinoma) blood was taken immediately from the ovarian veins and a cubital vein after laparotomy on the occasion of a surgical intervention according to Wertheim-Held. Fibrinogen was isolated from plasmas by affinity chromatography at fibrin monomer Sepharose and characterized by SDS-PAGE. With one exception proteolytically changed fibrinogens could be demonstrated in all plasmas. In 7 cases the fibrinogens from ovarian blood were more degraded than fibrinogen derivates in the blood obtained from cubital veins. It is assumed that the proteinase and/or plasminogen activator activities of tumor tissues are of importance for the observed proteolytic effects.

Adenocarcinoma↗
PubMed1985

[Intrathecal morphine administration in pain therapy following extensive gynecologic operations. Clinical study].

Experiences with intrathecal morphine analgesia in 36 patients undergoing Wertheim-Held hysterectomy are reported. Postoperative painrelief, bloodgas-parameters (pO2, pCO2, pH, SBE, SAT), analgetica demand, side-effects are compared with 23 patients of a control group. 95% of patients with intrathecal morphine analgesia were postoperatively without pain for at least 24 hours. The postoperative demand of analgetic drugs could be reduced to less than 50% in the first 48 postoperative hours. Besides not significant decreasing of the pH-value no changing of the bloodgases was observed. The incidence of nausea, vomiting and headache were not increased. Considering the not in all cases avoidable development of a respiration insufficiency even after a little dosis of morphine this method seems to be a suitable treatment of postoperative pain which enables the early mobilisation of the patients.

Adult↗
PubMed1983

[Alpha 1-globulin levels in patients with cancer of the genital tract].

Electrophoretical investigations of plasma protein patterns in 59 patients suffering from carcinomas of the genital system provide some evidence, that the alpha 1-globulin fraction amounts to only 2% in 25% and less than 2% of total plasma protein in 19% of the examined persons. The normal range of alpha 1-globulin is 2 to 4%. Low alpha 1-globulin values are mainly the result of a diminished alpha 1-antitrypsin level.

Alpha-Globulins↗