Search PubMed⌕ Search

Biomedical subjects

R Lloyd

Publications and source records attributed to R Lloyd.

At least 55 records · Page 3Linked to original sources
PubMed1984

Secretory diarrhea with islet cell hyperplasia and increased immunohistochemical reactivity to serotonin.

Two patients with secretory diarrhea and signs and symptoms consistent with the Verner-Morrison syndrome and islet cell hyperplasia are described. Both patients responded well to subtotal pancreatectomies. The morphologic changes in the pancreata were characterized by proliferation of islets associated with periductal and interstitial fibrosis. Immunohistochemical stains demonstrated increased staining for serotonin in islet cells. A few islet cells also stained for vasoactive intestinal polypeptide. The significance of these results is discussed.

Adenoma, Islet Cell↗
PubMed1983

Total thyroidectomy for Hürthle cell neoplasm of the thyroid.

The treatment of Hürthle cell neoplasms of the thyroid is controversial because of a lack of information about their clinical behavior and long-term follow-up. We reevaluated our experience of the past 33 years and compared our early experience with the more aggressive surgical approach used during the past ten years. We treated 62 patients with Hürthle cell neoplasm from 1949 through 1982. Twenty-six patients had benign neoplasms and 35 had malignant neoplasms proven by capsular or vascular invasion or nodal metastasis. Fourteen deaths were directly attributable to recurrent or metastatic disease, three among those with benign lesions. An aggressive surgical approach, involving total thyroidectomy or early-completion total thyroidectomy following lobectomy for all tumors histologically malignant or larger than 2 cm, resulted in a lower recurrence rate (21% v 59%) and fewer operations per patient (1.7 v 2.9) than in patients having other operations.

Adolescent↗
PubMed1983

Predictive value of an abnormal hepatobiliary scan in patients with severe intercurrent illness.

Ten patients had severe intercurrent illness and the gallbladder could not be seen on a hepatobiliary scan. In 4, surgery and pathological examination showed that the gallbladder was normal; 1 had chronic cholecystitis and 5 had acute acalculous cholecystitis. This study indicates that a positive hepatobiliary scan may not be indicative of acute gallbladder disease in the seriously ill patient.

Adult↗
PubMed1982

The spectrum of pheochromocytoma in hypertensive patients with neurofibromatosis.

We have found an appreciable number of pheochromocytomas in patients with neurofibromatosis and concurrent hypertension (ten of 18 cases). At diagnosis, the patient age range was 15 to 62 years, the clinical appearance of the neurofibromatosis did not predict who would and who would not have pheochromocytomas, but the age at diagnosis was helpful in that our younger patients tended to have causes of hypertension other than pheochromocytoma. However, several causes of hypertension may coexist. The biochemical findings were highly diagnostic. The pheochromocytomas secreted epinephrine as well as norepinephrine and resided in or next to the adrenal gland. Where pheochromocytoma is the cause of hypertension, its resection generally results in a better control of hypertension than that obtained in patients whose BPs were elevated from other unknown causes.

3-Iodobenzylguanidine↗
PubMed1975

Smooth-muscle antibodies in infertility.

Sera from 77 infertile women and 77 post-partum controls were examined for autoantibodies by indirect immunogluorescence. 27 (35%) of the infertile group had smooth-muscle antibody compared with 2 (3%) controls. Significantly more infertile patients had anti-nuclear factor, and reticulin antibodies were also more commonly found in this group. The differences for organ-specific autoantibodies between the two groups were not significant. There was no correlation between the occurrence of smooth-muscle antibodies and immunofluorescent anti-sperm antibodies. The high frequency of smooth-muscle antibodies in infertile women requires further study to determine whether an underlying viral infection is involved.

Antibodies, Antinuclear↗
PubMed1975

Reticulin antibodies in patients with coeliac disease and their relatives.

The sera of 69 index coeliac patients, 121 of their first-degree relatives, and 104 controls were screened for the presence of reticulin antibodies. Among the untreated coeliac patients 75% of adults and 93% of children had reticulin antibody in their serum. Reticulin antibody was not present in any adequately treated coeliac patient. Of the first-degree relatives, 21 were reticulin antibody positive; 17 of these were biopsied and 12 were shown to have coeliac disease. Sixty-five of the coeliac relatives who did not have reticulin antibodies in their sera were biopsied and two had coeliac disease. Of the 68 relatives and 63 controls with normal biopsies, five of the relatives and four of the controls were reticulin antibody positive.

Adolescent↗