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Biomedical subjects

R Livingston

Publications and source records attributed to R Livingston.

69 records · Page 4Linked to original sources
PubMed1978

Chemotherapy for colorectal cancer with 5-fluorouracil, cyclophosphamide, and CCNU: comparison of oral and continuous iv administration of 5-fluorouracil.

Forty-six adult patients with colorectal cancer were treated with cyclophosphamide and CCNU administered orally and 5-fluorouracil (5-FU) administered either orally or by continuous iv infusion (FCC-CIF), depending on the availability of hospital beds. The overall response rate in 37 patients with measurable disease was 25%. The response was greater in patients who had had no prior treatment (seven of 20 versus two of 17) and in patients treated with FCC-CIF (six of 19 versus three of 18). Among patients receiving FCC-CIF, response was also greater in those who had received no prior therapy (five of nine versus one of ten). The overall median survival was 7.5 months, regardless of the route of administration of 5-FU. Further investigations are indicated to study the efficacy of 5-FU administered by continuous iv infusion in combination with other agents in patients who have had no prior treatment.

Administration, Oral↗
PubMed1977

Antibiotic-resistant Staphylococcus aureus in dermatology and burn wards.

Staphylococcus aureus isolated between 1967 and 1975 from the nose and skin lesions of patients in dermatology wards and from the burns of patients in a burns unit in Birmingham showed a high incidence of multiple antibiotic-resistant strains in both environments. Over 20% of the strains isolated from patients on admission to the dermatology wards were multiresistant. Resistance to benzylpenicillin, tetracycline, erythromycin, and fusidic acid was common in the dermatology wards; a smaller proportion of strains were resistant to lincomycin, and few (since 1972 none) were resistant to methicillin; resistance to novobiocin and chloramphenicol was uncommon. In the burns unit, fusidic acid resistance was uncommon, but resistance to benzylpenicillin, tetracycline, erythromycin, novobiocin, neomycin, methicilin, and lincomycin was common. Several of the antibiotics to which resistance was common in the burns unit were rarely if ever used there; strains resistant to these antibiotics probably remained common in the ward through the frequent use of other antibiotics, especially erythromycin, to which these strains were also resistant.

Anti-Bacterial Agents↗
PubMed1976

Phase I studies with Baker's Antifol (BAF) (NSC 139105).

Phase I studies were conducted in 58 adult cancer patients with Baker's Antifol (BAF), a new active-site directed inhibitor of dihydrofolate reductase. Dose escalation ranged from 10 to 250 mg/m2/day X 5 days and courses of treatment were repeated every 2-3 weeks. Biologic effects were observed mostly at doses greater than 100 mg/m2/day X 5 days. The patients developed myelosuppression during 19% of the trials. Other types of toxicity were dermatitis in 12 to 30% and stomatitis in 7 to 38% of the trials. Toxicity was directly related to the impairment of the patient's liver function. Two partial responses (in a patient with adenocarcinoma of the lung and a patient with transitional cell carcinoma of the bladder) occurred. BAF is an active new chemotherapeutic agent which deserves further clinical trials in patients with various malignancies.

Adolescent↗
PubMed1975

Effects of synthetic androgen fluoxymesterone on triglyceride secretion rates in the rat.

Fluoxymesterone, a C-17 methylated derivative of testosterone employed in the treatment of renal-failure patients with refractory anemia, was administered to Sprague-Dawley rats and the effects on plasma triglyceride (TG) and immunoreactive insulin (IRI) levels and the rate of hepatic triglyceride secretion (TGSR) into plasma determined (Triton). Animals treated with fluoxymesterone demonstrated significantly lower TG (less than 0.05) and no alteration in TGSR. These findings are consistent with other observations which suggest that the triglyceride-lowering effect of androgens results from an accelerated rate of removal of triglyceride-rich lipoproteins from plasma.

Animals↗
PubMed1974

Target structure and echo spectral discrimination by echolocating bats.

Echolocating bats can use sonar to discriminate among targets which reflect echoes differing in spectral distribution of energy but not in overall intensity. They can detect differences smaller than 1 millimeter in fine target structure. Bats may be capable of classifying targets from echo spectral signatures and might thus be able to distinguish among flying insect prey by sonar.

Animals↗
PubMedDate not supplied

Youth homicide.

Explore the source record for details and available documents.

Adolescent↗
PubMedDate not supplied

Plantar abscess in the diabetic patient.

This is a report on 42 plantar abscesses in 40 patients with diabetes mellitus. Data concerning the mode of origin, the microorganisms involved, the antibiotics used, the end results or treatment, and the length of stay are given. Several typical cases are presented. Below-knee amputation can usually be avoided in diabetic patients with plantar abscess. The extremity can often be saved by a team consisting of specialists in infectious diseases, vascular surgery, and orthopaedic surgery.

Abscess↗