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Biomedical subjects

R Liu

Publications and source records attributed to R Liu.

At least 361 records · Page 20Linked to original sources
PubMed1990

Clinical trial with somatonorm in idiopathic growth hormone deficiency in children.

This article reports the efficacy and safety of treatment with Somatonorm in 9 children with idiopathic growth hormone (GH) deficiency in China. The growth velocity increased from 2.6 +/- 0.2 cm/year before treatment to 10.7 +/- 0.5 cm/year at the end of 1-year treatment. The increment of human growth hormone (hGH) level and area under the response curve above the baseline level were larger after one injection of Somatonorm at the dose of 0.1 IU/kg sc than that of 0.17 IU/kg im. Increments of delayed bone age were not significant. There was no correlation between the increase of height growth velocities and the serum Somatomedin-C (SMC) levels during hGH therapy (r = -0.055). Blood sugar levels and blood alkaline phosphatase concentrations increased significantly after therapy. There were no significant side effects. Serum T4 levels of 3 patients dropped below normal after treatment. Serum anti-hGH antibody appeared at 3-12 month in 2 patients, but it did not attenuate the growth velocity.

Child↗
PubMed1990

[Objective display on phenomena of propagated sensation along channels (PSC)--changes on the infrared thermal image channels pathway of upper extremity].

This paper reported the observed results on changes of the infrared thermal image of upper extremity induced by needle "Hega" (LI 4), "Daling" (P 7) and "Neiguan" (P6) points. The results indicated that 10 out of 23 cases whose higher and middle temperature bands of upper extremity distributed along the "Dachang" (Large Intestine) channels, when they felt phenomena of propagated sensation along the "Dachang" channels induced by needle "Hegu" points. Those effects did not appear in the objects who did not feel PSC along the "Dachang" channels induced by needled points. Above results provide an objective basis for the phenomena of channels and suggest that the phenomenon of PSC is an objective fact in human body.

Acupuncture Points↗
PubMed1990

[Objective observation on phenomena of sensation along channels (PSC) and QI reaching to affects area (QIRA)--the influence of acupuncture points on infrared thermal image of face].

Thirty three patients and nine volunteers were observed. 18 out of 33 patients felt PSC and Qi reaching to face induced by needle points. The QiRA rate was 80% in patients with face diseases. During acupuncture "Hegu" (LI 4) points, most of the patients felt PSC reaching to their faces and sensed heat in face. The infrared thermal image demonstrated that the temperature of face skin increase and the hyperthermal areas coincided basically with the pathway of "Yangming" channels. Those effects were more than the effects of the other objects who didn't feel PSC or sensed Qi reaching to face induced by needle "Hegu" (LI 4) or "Daling" (P 7) Points. The difference between the two groups was statistical significant. The temperature rising responses induced by needle points were not the results of natural fluctuation. The above results indicate that the PSC and QiRA is objective existence.

Acupuncture Points↗
PubMed1990

Epidemic non-A, non-B hepatitis in Xinjiang. Clinical and pathologic observations.

131 cases of epidemic hepatitis from two villages in Xinjiang, were admitted to the provisional infectious diseases hospital from February to April 1987. In 125 (95%) patients neither anti-HAV IgM nor anti-HBc IgM were positive. 118 (90%) were drinking water from a local stream of the Hotan River. The study was conducted on 125 patients aged from 5 to 90 years, with a mean of 26.4 years. There were slightly more males than females, a ratio of 1.5 to 1. The incubation period was roughly estimated to be 17 to 37 days (mean 24.8 days). All subjects were jaundiced. 12 patients (including 6 pregnant women) had cholestatic symptoms. Except one woman who died of postpartum bleeding, all patients ran a benign course without fulminant hepatic failure. Pathologic changes of liver biopsies from 35 cases included lobular damage and inflammation, ballooned hepatocytes with clear cytoplasm and delineated cell membrane which were named "clear cell". There were cholestasis of different degrees in the acute icteric stage and fatty changes in the convalescent stage. It was seen under the electron microscope that the livers of 8 cases had neither tubular structure nor sponge-like inclusions, but had nuclear changes including curled edge of nuclear membrane and nuclear heterochromatin condensed in masses. Liver biopsies were repeated in 7 cases followed up for 6-13 months, and hepatohistology was normal in 5. Of the other two cases there was one of each.

Adolescent↗
PubMed1990

Gossypol-induced alterations of aminophospholipid composition in human sperm.

Gossypol-induced alterations of aminophospholipid composition in human sperm were observed and the effects of some factors on these alterations were investigated. The alterations of aminophospholipid composition of human sperm induced by gossypol included a progressive decrease in the levels of phosphatidylethanolamine (PE) and phosphatidylserine (PS) when gossypol concentrations ranged from 5-500 mumol/L, and a progressive increase in the level of (LPE) at lower gossypol concentrations (5-50 mumol/L). The conversion of PE into lysophosphatidylethanolamine (LPE) was strongly enhanced by Ca2+ and inhibited by 0.5 mmol/L EDTA, while PMSF, NEM, iodoacetamide and Zn2+ had no effect. This conversion was weaker in sperm with stripped surface proteins than in normal sperm. In addition, three surface proteins (MW 80, 60 and 40 kD) were fixed on the plasma membrane by gossypol treatment. The significance of gossypol action and the possibility that sperm PLA2, PE and some surface proteins might play an important role in the physiological acrosome reaction of human sperm, as well as in oocyte penetration, are discussed.

Gossypol↗
PubMed1989

In vitro evaluation of cisplatin interaction with doxorubicin or 4-hydroperoxycyclophosphamide against human gynecologic cancer cell lines.

Doxorubicin, cisplatin, and cyclophosphamide are the three drugs most commonly used in the treatment of ovarian cancer, but no effect greater than additivity was observed for any combination of these drugs in the present study. Only a few studies have been reported concerning the degree of their additivity or their best order of sequencing. In our in vitro studies, cisplatin in combination with doxorubicin or 4-hydroperoxycyclophosphamide (4HC) was tested against seven human gynecologic tumor-cell lines in different sequences, using a double-agar layer tissue-culture system. Drug interactions with respect to inhibition of tumor clonogenicity were evaluated by isobologram and fractional survival methods. Doxorubicin and 4HC were sequenced simultaneously and at 1, 6 and 24 h after cisplatin, and cisplatin was sequenced at 1, 6 and 24 h after 4HC. The isobolograms constructed for doxorubicin or 4HC plus cisplatin revealed strict additivity between these agents against ovarian cancer clonogenicity. Both doxorubicin and 4HC showed the greatest additivity when used simultaneously and at 1 h vs 6 or 24 h after cisplatin. Although the mechanisms by which these sequencing effects occur are unknown, these studies provide new leads for the design of clinical trials with combinations of these three agents.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1989

Effects of granulocyte-macrophage colony-stimulating factor on in vitro growth of human solid tumors.

Solid tumor biopsies from 33 patients were tested in vitro to evaluate the growth modulatory effects of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF). In 29 of 33 studies (88%), addition of GM-CSF either had no effect on in vitro growth, or induced growth inhibition. While significant growth inhibition was observed in 10 studies, marked inhibition was only observed in three studies. However, all dose-response curves were usually flat, suggesting indirect effects. Moderate growth stimulation was observed in four instances, which may have been due to residual granulocyte-macrophage progenitors within the biopsies. We conclude that GM-CSF has little or no growth-modulatory effect on most nonhematopoietic neoplasms. The primary role of GM-CSF in patients with solid tumors appears to be in prevention or reversal of myelosuppression associated with therapy. Thus, while GM-CSF seems unlikely to have a role in monotherapy of cancer, it is also unlikely to have its utility compromised by enhancement of tumor growth.

Antineoplastic Agents↗