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Biomedical subjects

R Leoni

Publications and source records attributed to R Leoni.

10 recordsLinked to original sources

Early reoperation after vertical rectus muscle surgery.

PURPOSE: Adjustable suture strabismus surgery has a success rate between 90% and 94%. In some patients, undesirable deviations are noted in the first week after surgery. In this article, we describe a method of reoperation in the first week of the initial repair in an outpatient clinical setting. METHODS: A retrospective review of clinical records from 1990 to 1998 identified 7 patients who underwent reoperation of the original surgical procedure in a clinic setting. All patients had vertical deviations that were overcorrected and had a reversal of their diplopia. RESULTS: Follow-up ranged from 3 months to 59 months. All patients were free of diplopia and were either orthophoric or had small phoric deviations. CONCLUSIONS: Proper identification of patients with strabismus as a result of overcorrected adjustable sutures and prompt reoperation in the first week after surgery are possible and prevent the need for repeat anesthesia in the operating suite.

Adolescent↗

[Hypercalcitoninemia and disorders of dentition development. A family study].

INTRODUCTION: A lot of factors interfere in the physiopathology of the exfoliation of the primary teeth. One of the most important factors is bone shuffle which is due to osteoclastic activity; this activity is controlled by a hormonal equilibrium. CLINICAL CASE: The aim of the present study was to correlate primary teeth's exfoliation delay in two brothers with their hypercalcitoninemia. They had a positive familiar anamnesis for thyroid medullar cancer; this disease is notoriously associated with hypercalcitoninemia. CONCLUSIONS: The connection between a high basal and after-stimulation seric level of calcitonin and a lower activity of osteoclasis is evident. Thus, i also appeared evident to us the connection between the hormonal disease of the two children and the delay of exfoliation of their primary teeth. In these cases, it is important to control periodically the patients in order to prevent or to diagnose early isolated medullar thyroid cancer or a multiple endocrine adenomatosis.

Adolescent↗

[Multiple peg-shaped teeth associated with acrocephalosyndactyly. A variant of the Saethre-Chotzen syndrome? A clinical case].

INTRODUCTION: The SC syndrome is relatively common among craniosynostosis syndromes, and it is transmitted as an autosomal dominant trait. The syndrome was first recognized and described by S. and C. (1931-1932), but that most extensive discussion of the disorder was published by Pantke et al. in 1975. He systematically described the most and the least common marks of that syndrome. CLINICAL CASE: We thought it right to report a case we met and observed, because together with the S.C. syndrome's marks, there was the presence of multiple peg-shaped teeth. This peculiar mark is common to many orger craniosynostotic syndromes, but, we think it has never been described in "acrocephalosyndactyly type three" clinical cases. As a matter of fact, in literature, they have described in that syndrome, only lateral incisors shape anomalies. CONCLUSIONS: Even if in our patient the syndrome had a poor expressivity (there were scarce cranio-facial anomalies), and even if it came out there was no familiarity, it was peculiar because of the presence of multiple peg-shaped teeth. Besides, we think it is important to recognize that syndrome (which diagnosis is today still clinical because of the absence of peculiar laboratory aids), in such a way as to advice the female patient and to suggest her, in case of pregnancy, to go to a Uman Genetic Service for a an advice.

Abnormalities, Multiple↗

A planar second-order DC SQUID gradiometer.

In this work we describe a DC SQUID gradiometer, sensitive to the second spatial derivative of the magnetic field. The sensitive area of the gradiometer is the inductive body of the DC SQUID itself. The isoflux line distribution generated by a dipolar source, obtained by performing magnetic measurements with an array of such detectors, is relatively complicated, but its localisation capability is similar to that one usually achieves with axial detector arrays. Planar gradiometers also show a better resolution for near sources and a stronger rejection of far disturbances. The final device is expected to have an inductance of a few hundreds of pH in order to obtain performances typical of a low noise DC SQUID. The pick-up coils will be the combination of four square holes of 500 microns side with a 1.05 cm baseline. Due to the magnetic field concentration (in the final device it can be a factor 10) the gradiometer will have a sensitivity of 10(-11) T m-2 Hz-1/2 and a field sensitivity of about 2 fT Hz-1/2. Some preliminary results, obtained on detectors with an intermediate area between the prototype and final device, are reported here. The process used to fabricate this second-order gradiometer is based on Nb-NbO chi-PbAuIn Josephson tunnel junctions. Some possible improvements will also be described.

Equipment Design↗

Meningioma with pseudoglandular pattern. A case report.

A falx meningioma in an 11-year-old girl had a hemangiopericytomatous and papillary pattern, but the dominant histologic feature was a pseudoglandular arrangement of the tumor cells, closely imitating an adenocarcinoma. The gland-like spaces resulted mainly from dissolution of the centers of cell nests, and to a lesser extent from the fusion of papillary processes. The tumor-recurred locally five years after surgery and maintained its pseudoglandular pattern. Recognition of the existence of a pseudoglandular variant of meningiomas can prevent the mistaken diagnosis of a metastatic adenocarcinoma and other similar tumors.

Child↗

Biomagnetic measurements of spontaneous brain activity in epileptic patients.

In the last few years there has been an increasing interest in the magnetic activity due to bioelectrical currents flowing in the brain. In this paper preliminary results are reported concerning spontaneous magnetic brain activity in 36 patients affected by different kinds of brain disease; in most of these cases the symptoms were induced by localized pathology (atrophies, scars, tumors). Measurements were carried out with the simultaneous recording of the EEG. At present one of the most interesting features of magnetic detection seems to be its high localizing ability in cases of cortical foci, and sometimes its ability to show activities not evident in the EEG. These features seem to be very encouraging for the search for technical improvements, with the aim of making the magnetic technique a candidate for current diagnostic purposes.

Brain↗

[Traumatic gut perforation (seat-belt syndrome): a case report].

Seat belts have dramatically reduced the severity of traumas in car accidents. On the other hand, specific lesions have appeared, related to seat belt use. These lesions are defined as "seat belt syndrome". The Authors describe an intestinal medio-ileal perforation due to seat belts in a child.

Child↗

[Reinterpretation of the hepatic abscess, a new dimension in abdominal digestive surgery].

Pyogenic abscess of the liver is viewed here as a surgical disease, which appears to raise doubts as to its actual identity. Though located in a given abdominal organ, such abscesses find it hard to recognize this as their exclusive setting and attempt to shrug off these traditional confines. They aspire, rightly or wrongly perhaps, to symbolize a splanchnic context, though, in actual fact, the latter--at least for contingent, doctrinal reasons--is confined to the bipolar liver-bowel system. This context presents its candidacy as playing a leading role in a disease of such importance as to be regarded almost as the "Caudine Forks" of the very process of "surgical" dying. Liver abscess and multiorganic or multisystemic organ failure (MOF or MSOF) might thus be viewed as the two opposite poles (taxonomically definable) of a single clinical condition, which fans out over a broad area and for the most part is only barely known to us. Though is characterized by its abdominal location, it would be all too simple to define the condition as abdominal. In this case, in fact, the abdomen speaks an unusual language, not the habitual, traditional, "spatial" language of location, but the as yet uncertainly articulated "biological" or, why not, even "biosurgical" language of mediation. Is this then a turning point in the pathological field? No, if by that we mean a new concept of the problem. In effect, the concept dates back several centuries and, moreover, darries a heavy burden of responsibility, such as, for instance, having induced the Nobel Prize-winner Elie Metcknicoff (Metcknicoff E., The prolongation of life. London, Heinemann, 1907) to come up with theories appropriated and implemented surgically by Sir William Arbutnot Lane, gaining him nothing but sad notoriety (Gordon R., Great Medical Disasters, Hutchinson, London-Melbourne, 1983). "Concept" is a euphenism, and a more appropriate term might be simply "intuition". The real innovation lies in reviving this old intuition, reinterpreting it now, in fact, as a "concept". The code for this modern interpretation has barely been sketched out in its essentials, but is daily going from strength to strength.(ABSTRACT TRUNCATED AT 400 WORDS)

Endotoxins↗