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Biomedical subjects

R Lenzi

Publications and source records attributed to R Lenzi.

At least 73 records · Page 4Linked to original sources

A new colpocystourethropexy for female stress urinary incontinence.

A new technique for the treatment of female stress urinary incontinence is described. It consists of colposuspension obtained by suprapubic placement of two double monofilament sutures in a spiral fashion on the lateral vaginal walls, which are fixed proximally to a Cooper's ligament and tied distally one to the other over the rectus fascia. This technique has been successfully employed in a preliminary series of 26 patients and it appears to be easy to perform and with a wide application range.

Female↗

Surgical treatment of rectourethral fistulae.

9 male patients with rectourethral fistula were treated. Fistulae were congenital in 1 case, iatrogenic in 6 cases and traumatic in 2 cases. In 8 cases we used an abdominoperineal approach with omentoplasty or peritoneal flap; in 1 case a perineal approach was made. In 2 cases it was also necessary to use a transpubic approach to the posterior urethra. Good results were obtained in all cases. The importance of a proper radiological investigation of the fistulous tract and the use of omentoplasty are both emphasized.

Adult↗

Vaginal calculi associated with vesicovaginal fistulae.

Three cases of endovaginal stones associated with vesicovaginal fistulae are described. One fistula was of congenital origin, and the other two were recurrent post-hysterectomy fistulae. Other possible causes of this unusual stone location are neurogenic bladder, ectopic ureteral orifice and vaginal outlet obstruction. The radiologic appearance and the surgical treatment of vaginal calculi are discussed.

Aged↗

Serum beta 2 microglobulin levels in patients with renal cell carcinoma.

Serum B2m concentrations were evaluated preoperatively in 40 patients with renal cell carcinoma and normal renal function, as assessed by serum creatinine less than 1.4 mg/dl, and compared with those of 23 age-matched controls. Mean value +/- SD was 3,088 +/- 966 ng/ml for renal cancer patients, while controls had a value of 1,800 +/- 240 ng/ml. Statistical analysis, performed by Student t test, revealed a very high degree of significance (p less than 0.0005). No statistically significant differences were found between groups of patients classified according to tumor stage and cell type. Seventy percent of renal cell carcinoma cases had preoperatively elevated serum levels of B2m.

Adenocarcinoma↗

Treatment of male urethral calculi.

We treated 14 male patients for urethral stones during a 17-year interval. The calculi were located in the posterior urethra in 7 patients and in the anterior urethra in 7. Anatomical alteration of the lower urinary tract was an important predisposing factor, since 11 patients had history of bladder and urethral surgery or disease, 2 had an associated neurogenic bladder, 6 had urethral strictures or diverticula and 3 had concomitant bladder stones. Urethroplasty was performed in 5 cases, surgical removal of the stone in 3, retrograde manipulation inside the bladder in 4 and electrohydraulic endourethral lithotripsy in 2. The latter technique appears to be particularly effective for endoscopically accessible stones.

Adolescent↗

One-stage skin graft urethroplasty in anterior middle urethra: a new procedure.

A new procedure with the use of a free skin patch graft for the surgical treatment of strictures located in the mid anterior urethra is described. To avoid the formation of a urethral diverticulum, the skin graft is sutured dorsally rather than ventrally and subsequently is fixed on the tunica albuginea of the corpora, which support the patch. We describe 4 different procedures according to the extent of the stenosis and the degree of involvement of the spongiosum tissue by the inflammatory process. The preliminary results obtained in a small series of 6 patients are presented.

Humans↗

Resistance to tobacco necrosis virus induced by salicylate in detached tobacco leaves.

Sodium salicylate reduced both the size and viral antigen content of non-self-limiting necrotic lesions produced by tobacco necrosis virus (TNV) in detached tobacco leaves during the partly localized reaction to virus. The antiviral effect of salicylate occurred at concentrations close to the limits of toxicity, and depended on the timing of administration. Both viral antigen accumulation and lesion size were strongly inhibited by a continuous supply of salicylate before or just after virus infection. Salicylate treatment did not prevent TNV accumulation when given after the establishment of infection or when arrested 24 h after TNV inoculation. Both procedures, however, did limit lesion enlargement. These results constitute a limit for the use of salicylate as a chemotherapeutic agent but do not exclude its use in limiting the pathogenetic effects of the virus. The salicylate treatments induced the formation of four pathogenesis-related proteins (PRs). The PRs formation was stimulated during the first 8 h of treatment and persisted for some time after the salicylate supply was discontinued. No correlation was found between the presence of PRs and the reduction of TNV accumulation: low salicylate concentrations (0.25 mM) inducing the formation of the PRs did not induce resistance against the multiplication and/or cell-to-cell spread of TNV.

Plant Viruses↗

Surgical treatment of male urinary incontinence.

Between January 1975 and December 1981 we treated 34 men with urinary incontinence with surgical intercavernous embedding of the bulboperineal urethra along its entire length. The etiology of incontinence was sphincteric damage following either prostatectomy (30 cases) or pelvic trauma (4 cases). All patients had complete neurologic integrity of the detrusor, 25 (75 per cent) had complete urinary continence, 5 (15 per cent) experienced considerable improvement, while 4 were failures. Followup ranged from 7 years to 4 months. Details of the surgical procedure are described, preoperative and postoperative management is emphasized and results are presented.

Adult↗

Bladder herniation after transpubic urethroplasty.

We report 2 cases of bladder hernia following repair of complex posterior urethral strictures by transpubic bulboprostatic anastomosis and omentoplasty. One patient was treated successfully by repair of the defect with a synthetic mesh. The presence of concomitant pubic diastasis is thought to be a contributing factor, as well as the use of omentum to fill the dead space.

Hernia↗

Experience with omentoplasty.

A 6-year experience with omentoplasty is presented. During this period pedicled omentum was used in 145 procedures of reconstructive urologic surgery. On the basis of this experience the authors conclude that omentoplasty is an essential part in urological reconstructive surgery.

Adolescent↗

Report of a case of familial male internal pseudohermaphroditism.

A rare case of male internal pseudohermaphroditism is described. The patient had normal external male sexual characteristics but unilateral cryptorchidism. Three of his brothers had also cryptorchidism. The patient's parents were cousins. The patient's karyotype was normal.

Adult↗