Biomedical subjects

R Ledda

Publications and source records attributed to R Ledda.

4 recordsLinked to original sources

PubMed1985

Captopril mediated decrease of aortic regurgitation.

The effect of captopril mediated afterload reduction on aortic regurgitation was investigated in 10 patients. Regurgitation was quantitated by means of the regurgitation fraction and the relation of regurgitant volume to end diastolic volume. These variables were derived from gated radionuclide ventriculography. After captopril treatment the blood concentration of angiotensin I rose whereas that of angiotensin II fell significantly. The conversion of angiotensin I to II was reduced to about 50% of the control value. Whereas blood pressure and heart rate did not change significantly, the regurgitation fraction and the regurgitant volume, normalised to end diastolic volume, were significantly reduced by captopril treatment. The ejection fraction remained essentially unchanged. These findings suggest that captopril reduces aortic regurgitation by reducing afterload.

Angiotensin I↗

PubMed1985

[Results of treatment of achalasia with special reference to gastroesophageal reflux].

Patients with achalasia, which had been treated in the Department of Surgery, University of Bonn, from 1953 to 1983 (n = 142), were examined by a detailed questionnaire (n = 90), endoscopy and biopsy (n = 47), esophagography (n = 53) and by gastric reflux scintigraphy (n = 12). The results of dilatation and surgical procedures are compared. Although the incidence of gastric reflux was very seldom, an esophagitis could be seen frequently. The dilatation of the esophagus is succeeded, if there is left any myogenic tone. Otherwise an esophagomyotomy by left thoracotomy should be performed without an antireflux operation.

Adult↗

PubMedDate not supplied

Isolation of Chlamydia trachomatis during IVF-ET.

The Authors isolated Chlamydia Trachomatis from the granulosa and from the spermatozoa of an infertile couple taking part in the IVF-ET program at the Department of Obstetrics and Gynaecology of the University of Pisa.

Adult↗

PubMedDate not supplied

A possible role of Chlamydia trachomatis in unexplained infertility and sterility.

To estimate the presence of latent Chlamydia Trachomatis (C.T.) infections, we have carried out a study on a selected group of couples affected by unexplained sterility and infertility. We examined 193 women and, as control group 210 healthy fertile women. For both groups the main risk factors that could explain the infection epidemiology have been analyzed. The parameters considered are age of first intercourse, number of partners, social-economic conditions and number of voluntary abortions. Amongst all the causal agents of sexually transmitted diseases (STD), C.T. was most common, with an incidence of about 12 per cent in the study group versus the 5.7 per cent of the control group (chi 2 = 4.12).

Abortion, Habitual↗