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Biomedical subjects

R Laumonier

Publications and source records attributed to R Laumonier.

At least 37 records · Page 2Linked to original sources
PubMed1976

An optical and ultrastructural study of the localization of carcinoembryonic antigen (CEA) in normal and cancerous human rectocolonic mucosa.

An immunoenzymologic method using peroxidase-labeled antibodies has been applied for the localization of carcinoembryonic antigen (CEA) on frozen sections, on Araldite-embedded sections, and on isolated cell preparations of normal rectocolonic mucosa and of rectal and colonic cancers (adenocarcinomas and one villous tumor). CEA appears as a component intimately associated with the external coating of the striated border of the normal columnar cell and with the external coating of the apical pole of the cancerous cell. CEA is also found as an intracellular component of the normal epithelial cell of the rectocolonic mucosa, mainly the goblet cell. In tumors, it appears as an intracellular component of the mucussecreting cell. Its presence in the cell coat and interior of the cell correlates with the degree of differentiation of the cells, whether cancerous or not. Progressive accumulation of CEA in the normal colonic epithelial cell has been observed in cells undergoing maturation. Its release by the mature goblet cell has also been observed. These results confirm that CEA is a normal glycoprotein constituent of the epithelial cell of the human adult rectocolonic mucosa, synthesized and discharged by this cell. The difference in CEA content, already reported, between the cancerous and the normal rectocolonic mucosa appears quantitative and not qualitative.

Adenocarcinoma↗
PubMed1975

[Detection of anti-DNA antibodies by electroimmunodiffusion. Comparison of the results with the study of antinuclear factors by immunofluorescence].

The detection of anti-DNA antibodies was carried out by the electroimmunodiffusion method. The results were compared to those of the immunofluorescent method for anti-nuclear factors. Positive results were obtained with the electroimmunodiffusion method in 86% of the lupus erythematosus cases, 77% of the sero-positive rhumatoid polyarthritis cases and 67% of the scleroderma cases. They are comparable to those obtained by other methods. The electroimmunodiffusion method allowed in 3 out of 54 sera to defect anti-DNA antibodies although no anti-nuclear factor was found.

Antibodies, Antinuclear↗
PubMed1975

Significance of precancerous lesions in the colon and rectum.

The turnover of the colonic mucosa sheds some light on the understanding of the precancerous stages. The colon mucosa operates through a constant and regular epithelial renewal. The regularity of this cycle is controlled by two membranous systems: the basement membrane as a sliding support- coat and the as a brake in the cells progression and thus in the mitosis. Any disturbance, in these system, brings about a large extension of the proliferative area, according to modalities common to all varieties of precancerous, polypous or non-polypous condition. On this poll of undifferentiated cells, with frequent mitosis risks of cancerous changes are, all the higher, that the undifferentiated areas or growing areas are more extended. This explains the unequal tendency to malignancy of colitis, solitary polyps, villous polyps in layers, and multiple polyps.

Animals↗
PubMed1973

Acute renal failure associated with combined gentamicin and cephalothin therapy.

Three patients with normal renal function developed acute renal failure between the ninth and twenty-seventh days of combined gentamicin and cephalothin therapy. The dose of gentamicin (4-6 mg/kg/day) was in the normal range, but that of cephalothin (180 mg/kg/day) was abnormally high. The nephropathy was of the tubular-interstitial type and the clinical picture similar to that seen in acute drug-induced nephropathies. Frusemide was given only after the onset of renal failure. In these three patients the high intravenous doses of cephalothin combined with gentamicin were probably nephrotoxic.

Acute Kidney Injury↗