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Biomedical subjects

R Laue

Publications and source records attributed to R Laue.

At least 37 records · Page 2Linked to original sources
PubMed1980

[The importance of involutively conditioned and conditioned by morbidity alterations of enteral absorption and the nutrition of geriatric patients with obstructive jaundice and carcinomatous diseases (author's transl)].

In case of absorption examinations in younger and advanced age it is necessary to differentiate between involutively conditioned alterations of enteral absorption and those ones conditioned by morbidity. For this purpose the modified D-xylose-absorption test offers itself as a diagnostical remedy. The equivalently characteristic alterations in absorption kinetics of carbohydrates in cases of the occurrence of an obstructive jaundice, in patients in the stage of generalisation of carcinomatous disease and in the elderly may be demonstrated by the modified D-xylose-Test.

Aged↗
PubMed1980

[Autoradiographic investigations of age-dependent proliferation kinetics in the small intestine mucosa of rate (author's transl)].

Aging of cells depends on mitotic activity which is particularly evident in multicellular organisms. By means of histoautoradiography we studied the cell kinetics of the mucosa of the small intestine in a total of 244 Wistar rats aged 6 days, 6 weeks, 6, 12, 23 and 28 months, resp. We could demonstrate that the regeneration rate of cells per hour in the crypts of the small intestine and the migration velocity of the enterocytes differ in young and old individuals, and that the intermitotic cells have age-dependent properties as well. In addition, we could prove that intermitotic cells have a nongrowth fraction, too, which at an advanced age, decreases only slightly although significantly in terms of statistics. For the easily vulnerable crypt epithelium it is a reserve capacity and can b included in the proliferating pool if necessary.

Age Factors↗
PubMed1979

[Enteral resorption and tumor cachexia].

The rapid loss of the body weight of oncological patients in the advanced stage of the carcinomatous disease is caused by numerous pathophysiological mechanisms. With the help of the modified D-xylose absorption test was investigated which value have disturbances of the enteral absorption in the complex of causes for the development of a tumour cachexia. For the patients in the stage of generalisation of the carcinomatous disease clear disturbances in the enteral food intake could be proved in contrast to patients with carcinoma without general tumour symptomatology and healthy persons. The influence of chemo- and radio-therapy on the enteral absorption of patients with carcinoma was discussed. The forced alimentation of oncological patients with unspezific tumour symptoms must be regarded as a firm constituent in the treatment of patients with carcinoma.

Cachexia↗
PubMed1979

Effect of temperature on the transcription by bacteriophage T3-induced RNA polymerase.

Bacteriophage T3-induced RNA polymerase is rapidly inactivated at 42 degrees C. Addition of T3 DNA delays this process for 30 s and reduces the rate with which the enzyme activity is lost indicating that a labile binary complex between T3 DNA and polymerase must have been formed. The ternary complex between T3-specific RNA polymerase, T3 DNA, and nascent RNA chains obtained when the enzyme is incubated with T3 DNA, GTP, ATP, and UTP is stable to heat (42 degrees C) and only slowly inactivated by polyvinyl sulfate. The optimal temperature for the formation of polyanionresistant ternary complexes is 30 degrees C while the elongation of T3 RNA chains proceeds fastest at 38 degrees C.

Cell-Free System↗
PubMed1979

[Postoperative small intestinal absorption after cholecystectomy].

The postoperative resorption in the small intestine after cholecystectomie was found out by means of the modified D-xylose resorption test on the 2-th, 4-th, 6-th an 8-th postoperative day for 14 patients. The velocity and the dimension of the enteral resorption of D-xylose was lower in the immediate postoperative phase. The dimension of the D-xylose resorption was normalized on 4. p. o. day and obtained the preoperative starting-value on the 8-th postoperative day. The myoelectrical activity of the small intestine normalized in a shorter time after cholecystectomy than the enteral resorption. A formal parallelism consists between the normalisation of the motoric activity of the stomach and the xylose-resorption in the immidiate postoperative phase. For the small intestine resorption in the postoperative phase completely clarified and required further investigations. The influences of electrolyte displacement and disturbances of the microcirculation in the postoperative period in the small intestine resorption were discussed.

Adult↗
PubMed1979

[Postoperative intestinal absorption in old age (author's transl)].

The function of intestinal absorption was analysed in elderly patients before and after cholecystectomy by the help of the modified D-xylose-absorption test. A characteristic dependence upon the age for the process of intestinal absorption was demonstrated in the elderly not only preoperatively but also postoperatively. The effective intestinal absorption of D-xylose normalized postoperative by in freshly operated older patients more slowly than in younger ones.

Aged↗
PubMed1978

[Digestion and absorption in elderly man (author's transl)].

Morphologically first indications of an age-related alteration of pancreatic microscopic structures can be proved an age of fourty. In healthy elderly man functional capacity of exocrine pancreas is lowered. It can be proved by means of pancreatic function tests. Normally the digestive capacity will be sufficient provided a reasonable nourishment. Usually the intestinal absorptive capacity tends to decrease in the elderly. But following delayed intestinal transit of nutritients absorption to a certain degree can occur sufficiently. Considering the nutrition of elderly people recommendations are given.

Age Factors↗
PubMed1978

[Initial results of investigations into the proliferation kinetics of enterocytes (author's transl)].

The changes of absorption appearing in man and caused by aging are probably due to disturbances of the proliferation and exfoliation kinetics of the enterocytes of the small intestine mucosa. The relevant experimental examinations available are insufficient because the results were obtained from a few animals only. Our own systematic autoradiographic examinations of rats are designed to contribute to a clarification of this problem which is important for practice.

Adolescent↗
PubMed1978

[Intestinal absorption in the elderly (author's transl)].

The extent of intestinal absorption and malabsorption may be exactly stated by means of the method "generalized absorption". According to first-hand examinations an alteration of absorbing kinetics of D-xylose dependent on age could have been demonstrated. The velocity of absorption decreases in the elderly and the general absorbing process are prolonged. The extent of absorption restriction in the elderly are under physiological circumstances without clinical value. The health elder man disposes of the same power for a complete absorption of an offered substrate like the younger one. An increasing of cases with a malabsorption in the age may be explained by a increased multmorbidity in the elderly.

Adolescent↗
PubMed1976

[Aging and resorption].

The enteral absorption in dependence of age has been tested by D-xylose. From the additional investigation of the D-xylose reaction in the blood plasma one can detect statistically ascertained age relation in comparison between young and old healthy test persons. Though in old age the absorption process is retarded a sufficient absorption at a longer time at diminished speed of passage of the ingesta in old age.

Adolescent↗
PubMedDate not supplied

[Aspects of healthy and pathologically changed laryngeal epithelium in a model. 2].

Atrophy of laryngeal epithel at aged men can in model according to the literature lead back on prolongation of mitosis cycles. An increasing tendency of cornification and decreasing formation of pegs in range of basilar membrane are also demonstrable. Formation and development of a tumor instance a pathological evolution of tissue in model.

Aging↗