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Biomedical subjects

R Lasek

Publications and source records attributed to R Lasek.

At least 19 recordsLinked to original sources
PubMed2002

[Meta-analysis of the efficacy of adenosylmethionine and oxaceprol in the treatment of osteoarthritis].

The aim of this meta-analysis based on the literature was to gather all evidence of randomized clinical trials to assess the efficacy of adenosylmethionine (SAM) and oxaceprol in the treatment of osteoarthritis. Findings in MEDLINE and EMBASE were added to publications catalogued by the AkdA and a reference search. The meta-analysis was based mostly on pain scores but also on pain and function scores. We used the fixed effects and the random effects model.A superiority of SAM vs placebo ( n=468) could not be shown; the 95% CI of standardized difference of pain scores was (-0.89, 0.12). The comparison of SAM vs NSAIDs with seven studies ( n=850) did not show a difference: (-0.59, 0.19). This cannot be seen as proof for equivalence. A post-hoc analysis of SAM vs ibuprofen gave nearly a positive result for SAM: (-0.43, 0.02). No adequate placebo-controlled RCT was found. There was no significance for a difference between oxaceprol and NSAIDs using the four trials found (two diclofenac and two ibuprofen); the 95% CI of standardized difference of pain and function scores was (-0.19, 0.27). Since only a few trials with heterogeneous results were found which mostly have a low quality of the studies and/or publications, the results must be interpreted very carefully. The meta-analysis does not give enough evidence for the efficacy of SAM and oxaceprol for treating the symptoms of osteoarthritis, but it might be that there is a comparable effect to other NSAIDs.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1997

[Therapy recommendations of the Drug Committee of the German Medical Association--an instrument for quality assurance in drug therapy. Drug Committee of the German Medical Association, Cologne].

The growing flood of information on drug therapy, which is increasingly overwhelming the individual physician, and the simultaneous demand for high-quality, individual therapy, call for guidelines recommending appropriate therapeutic measures for a given indication. The Drug Commission of the German Medical Profession, a scientific committee of the German Medical Association, has set itself the task of providing assistance in this context by elaborating scientifically-based, practice-oriented therapeutic guidelines. These guidelines were drawn up in accordance with a defined procedure and represent the consensus reached between the appropriate independent experts, the general practitioners and the members of the executive committee of the Drug Commission. This review presents the background, aims, procedures and criteria for assessment involved in the elaboration of the guidelines and attempts to define the position of the therapeutic guidelines in comparison to similar activities of other institutions in Germany.

Drug Therapy↗
PubMed1997

[Limited prescribing freedom by federal cost regulation?].

The governmental budgeting of the overall expenses for medicines obviously does not impair the quality of medical treatment. But pharmaco-epidemiologic investigations are lacking. This regulation is just an instrument for diminution the health care expenses without interfering with the quality of prescription and provision of medicines.

Cost Savings↗
PubMed1994

Category-order effects in memory span.

When Ss are required to recall lists containing both words and digits, memory span is higher when the digits precede the words than when the words precede the digits. In Experiment 1, both forward and backward recall were tested; it was demonstrated that this category-order effect reflects the input position, and not the output position, of the items. Experiment 2 revealed that this effect was not eliminated by a filled retention interval. Experiment 3 showed that the effect was eliminated when lists were presented at a fast presentation rate. In Experiment 4, the effect was eliminated when Ss engaged in articulatory suppression. A 5th experiment extended the findings of Experiment 4 to the case in which lists are composed of semantically related or unrelated words. These results suggest that category-order effects reflect mnemonic activity that Ss engage in during list presentation and do not arise from structural characteristics of the memory system.

Humans↗
PubMed1986

[The influence of central monoaminergic systems on the anticonvulsive action of propranolol].

The influence of substances modulating the activity of central monaminergic systems on the anticonvulsant effect of propranolol was investigated with the maximal electroshock test in mice. The results demonstrated that especial the noradrenergic system plays an important role in modulating the efficacy of propranolol. Pharmacological stimulation of the noradrenergic system (e. g. with desipramine, pargyline, yohimbine) resulted in an enhanced anticonvulsant effect of propranolol. Compounds that suppress the noradrenergic transmission reduced this action. On the other hand manipulations of serotonergic (with 5,7-DHT, 5-HTP, PCPA) or dopaminergic (with 6-OHDA + desipramine, apomorphine) mechanisms seems to be without marked influence on the protective effect of propranolol in maximal electroshock.

5-Hydroxytryptophan↗
PubMed1985

[The neuropharmacology of beta adrenolytics].

The paper provides a survey of neuropharmacological fundamentals for the use of beta-adrenolytics in the treatment of psychiatric and neurological diseases. In particular there are discussed results of animal- and clinical-pharmacological experiments carried out in order to assess the influence of betaadrenolytics in disorders and diseases such as anxiety, psychoses, tremor, some kinds of addiction, migraine and epilepsy. The conclusion is that in spite of some ascertained clinical indications on the one hand and a variety of neuropharmacological results on the other the mode of action of betaadrenolytics at the level of the CNS remains still insufficiently explainable.

Adrenergic beta-Agonists↗
PubMed1983

[Effect of stimulation of the locus coeruleus on cobalt-induced epileptiform activity in the rat].

The effects of a short-time serial stimulation of the locus coeruleus (LC) on cobalt-induced focal epileptiform activity were investigated in unrestrained rats with chronically implanted electrodes. The results show a marked reduction of the spike-wave activity immediately after stimulation. The characteristic groups of "cobalt-spikes" are completely suppressed within 30 s and significantly reduced up to 120 s. This suppression was partly antagonized by pretreatment with the beta-receptor antagonist propranolol (2-5 mg/kg i.p.). On the other hand, the stimulation of other areas, lateral or medial of the LC (n. parabrachialis; stratum griseum centrale), reduced the spike-discharges only insignificantly. These data support the hypothesis that the noradrenergic system play an important inhibitory role in epileptiform activity.

Animals↗
PubMed1981

[Effect of drugs on laboratory diagnosis--effect of propranolol on selected laboratory values].

In the accessible literature the influence of beta-blockers on laboratory methods is estimated only little systematically and nearly exclusively on parameters of the glucose and lipometabolism. The influence on several methods in vitro is without relevance to practice. Own examinations showed that in 32 patients with essential hypertension of stage I (after Baumann and Nitschkoff) under therapeutic doses of 50--80 mg propranolol a day in none of the 18 chemical parameters tested after a four weeks' treatment significant deviations relevant to practice appeared in comparison to the parameters before treatment.

Adolescent↗