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Biomedical subjects

R Langer

Publications and source records attributed to R Langer.

At least 559 records · Page 31Linked to original sources
PubMed1982

[Radiologic aspects of the congenital arteriovenous malformations, Klippel-Trenaunay type, and Servelle-Martorell type (author's transl)].

In our study 13 patients with a Klippel-Trenaunay type and 7 patients with a Servelle-Martorell type of arteriovenous malformations were analyzed. The results demonstrate that these 2 entities can be differentiated by routine radiography. The Klippel-Trenaunay type of angiodysplasia does not need arteriography, whereas arteriography as well as phlebography are necessary in the Servelle-Martorell type of angiodysplasia, in order to show ectatic regions of the involved vessels. The differentiation between the above mentioned arteriovenous malformations and the F. P. Weber type of angiodysplasia is easy. In the F. P. Weber type of angiodysplasia a lengthening of the involved extremity, arteriovenous shunts, as well as alterations of the bone are characteristic.

Angiography↗
PubMed1982

[Contrast enhancement of the gyral pattern in herpes simplex encephalitis].

A case of herpes simplex encephalitis was examined by computer tomography. Both cerebral hemispheres showed contrast enhancement of the gyri. The cause of this is considered. The increased contrast medium accumulation in the affected areas is probably due to the marked vascular proliferation which can be demonstrated anatomically, and to the rapid escape of contrast from the capillaries into the interstitial spaces. The findings of other authors, which differ somewhat, are discussed.

Adult↗
PubMed1982

Plasminogen activator (urokinase) causes vascularization of the cornea.

The presence of a peripheral zone of (presumed intracellular) plasminogen activator in the normal rabbit cornea has suggested that activator, once released, might regulate the permeability of limbal vessels and angiogenesis, by plasmin-dependent pathways. Plasminogen activator (urokinase [UK]) in rabbit serum albumin (RSA) was injected once (20 microliter, 3.7 CTA U) into the corneal stroma, 2 mm from the limbus. Sprouts arose from the engorged circumlimbal vessels (16 of 20 corneas) beginning on the third day and grew into the cornea over the next several days. Histologically, PMNs were observed in association with growing vessels. Contralateral corneas injected with UK (in RSA) previously inactivated by 99.7% with the specific active site inhibitor, Phe-Ala-Arg-chloromethyl ketone showed minimal vessel engorgement or stromal edema and no vascularization (0 to 20 corneas). Injuries to the so-called (plasminogen activator-containing)"critical zone" of the cornea which elicit neovascularization possibly do so by causing extracellular release of endogenous plasminogen activator. Thus, in addition to initiating the destructive events of ulceration, activator might initiate increases in vessel permeability and also neovascularization, which would result in the eventual arrest of ulceration.

Amino Acid Chloromethyl Ketones↗
PubMed1982

[Congenital angiodysplasias of types F.P. Weber, Klippel-Trénaunay and Servelle-Martorell].

Basing our observations on a study of 47 cases of angiodysplasia of types F.P. Weber, Klippel-Trénaunay and Servelle-Martorell, we attempted to demonstrate that differentiation of these 3 syndromes is possible if criteria obtained from a non-invasive investigative method are used. This involves taking standard X-rays of the extremities (both sides) which are examined under direct magnification (0.1-01 mm) thus allowing the most exact possible analysis of the skeletal changes. In this way, the Weber syndrome should be suspected if bone prolongation is seen in association with loss of substances from the skeleton. In the Klippel-Trénaunay syndrome, the bone lengthening is not accompanied by bony lesions. In the Servelle-Martorell syndrome bony lesions go hand in hand with limb hypertrophy.

Angiomatosis↗
PubMed1981

Biocompatibility of polymeric delivery systems for macromolecules.

We previously reported the use of polymeric delivery systems capable of sustained release of substances with molecular weights up to 2 X 10(6). The current study examined the tissue compatibilities of these slow-release agents and of other polymeric materials. To observe in vivo host responses to specific implants, tests were conducted in the rabbit cornea. The cornea as an implant site has several advantages compared to other organs including its clarity, avascularity, sensitivity, and convenient access to view. Corneas were examined using stereomicroscopy and histology. Two polymers suitable for sustained macromolecular release, poly(hydroxyethyl methacrylate), and alcohol-washed ethylene-vinyl acetate copolymer, were noninflammatory. Other polymers considered for sustained macromolecular release, such as polyacrylamide and poly(vinyl pyrrolidone), produced significant inflammation.

Animals↗
PubMed1981

[Invasive and non-invasive radiologic diagnosis of talofibular ligament lesions (author's transl)].

A report is given on 413 patients having experienced a supination trauma. All these patients were submitted to radiography according to the technics of Böhler. Arthrographies of the ankle joint were additionally effected in 105 patients because of indistinct findings of the Böhler radiographs. The arthrography of the ankle joint proves to be an examination method bearing few risks and producing most reliable results provided that it is executed within 24 hours after the traumatic incident. The findings of arthrography of the ankle joint are presented and discussed.

Ankle Injuries↗
PubMed1981

[The localization and differential diagnosis of benign and malignant gynaecological tumours in the axial computer assisted tomogram (author's transl)].

40 computer assisted tomographies of the vagina, the uterus and the ovaries were evaluated. The differential diagnosis between malignant and benign neoplasms is difficult unless there is spread into the soft tissues. The early diagnosis of ovarian neoplasms by axial computer assisted tomography is impossible. We are of the opinion that axial computer assisted tomography should be performed as early as possible in the diagnosis of local recurrences of malignant tumours of the female genital tract.

Diagnosis, Differential↗
PubMed1981

[Plain film appearances of chondropathia patellae. Morphological changes after surgical treatment (author's transl)].

The localised patella defects in our material of 90 patients were largely unchanged up to nine months after surgical treatment. Persistence of soft tissue swelling round the knee correlates with continuing pain. In some cases there has been remineralisation of the patella, which can be regarded as a stage in healing. Unchanged or deteriorating radiological findings may be associated with clinical improvement or deterioration.

Humans↗