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Biomedical subjects

R Lambotte

Publications and source records attributed to R Lambotte.

At least 37 records · Page 2Linked to original sources
PubMed1993

[Lower urinary tract infections in women. Recent data].

Lower urinary tract infection (LUTI) is a common disease of young women. It usually has a favourable prognosis, but it must not be neglected in view of its frequent recurrences and of the important morbidity it creates leading to social and sexual discomfort. LUTI, therefore, must be diagnosed, and this is done essentially by bacteriological examination of midstream urine. As regards detection of asymptomatic bacteriuria, notably in pregnant or elderly women, the sensitivity of screening is distinctly enhanced by the nitrite and leucocyte esterase tests. Recent publications concerning treatment are in favour of single dose therapy. In uncomplicated urinary tract infections, single doses of antibacterial agents are as effective as the conventional 5 to 7 days administration, and they constitute the treatment of choice of LUTI. In pregnant women, this therapeutic method has the advantage of lesser toxicity and lower frequency of vaginal candidiasis. In patients with frequent recurrences of LUTI, several options are possible: low dose continuous treatment, prophylactic treatment after situations of high risk for reinfection, or self administered single dose as soon as the symptoms reappear. However, the last two methods need to be further evaluated by additional clinical trials.

Anti-Bacterial Agents↗
PubMed1992

High rate of multiple genital HPV infections detected by DNA hybridization.

Cervical smears collected from 450 patients involved in a clinical follow-up of cervical human papillomaviruses (HPV) infections were screened for the presence of HPV 6b, 11, 16, and 18 DNA by both dot blot and southern blot hybridization methods. Using very high stringency hybridization assays, the four HPV types could be easily distinguished by dot blotting. After a preliminary clinical sorting, 42.9% of the samples were found to be HPV-positive. Among the samples infected by a single HPV, type 16 was the most frequent (25.4% of the positive samples) followed by 6b (19.7%), 11 (8.3%), and 18 (7.2%). Double or even multiple infections by the different HPV types were detected at a very high rate (39.4% of the positive samples).

Belgium↗
PubMed1992

[Contribution of magnesium gluconate in intravenous tocolysis with ritodrine].

The purpose of this randomized study was to compare the efficacy of ritodrine alone (51) versus ritodrine plus magnesium gluconate (56). We concluded that high oral doses of magnesium therapy (4 x 3 gr) potentiate the effects of intravenous beta-agonists, allowing a reduction of the dosage needed and a better "tolerance". Considering the low side effects, it seems reasonable to consider using magnesium in the treatment of premature labour.

Administration, Oral↗
PubMed1991

Exteroceptive silent period of temporalis muscle in menstrual headaches.

The second exteroceptive silent period (ES2) of temporalis muscle was recorded on days 1 and 15 of the menstrual cycle in 17 women, 9 of whom suffered regularly from tension-type headaches during menstruation. Mean duration of temporalis ES2 was significantly shorter on day 1 of the cycle than on day 15. This difference was due to a marked menstrual reduction of ES2 in the headache subgroup. A positive correlation was found between ES2 durations and oestradiol/progesterone ratios. We hypothesize that the variations of ES2 during the ovarian cycle result from the modulatory effects of oestrogens on descending aminergic pathways that control excitability of inhibitory brainstem interneurons mediating exteroceptive suppression of jaw-closing motoneurons.

Adult↗
PubMed1991

[Metabolic impact of current estrogen-progestins and cardiovascular consequences].

In recent years, reduction of estrogen and progestogen dosages and use of new progestogens with less androgenic activity (desogestrel-gestodene-norgestimate) have apparently allowed combined oral contraceptives (OCs) to be associated with less frequent undesirable vascular effects. From an epidemiologic viewpoint, the atherogenic impact of new low-dose OCs is less marked, including in users over 40 years of age, but thromboembolic effects still persist--though at a lower level than with standard-dose products. From a metabolic viewpoint, the adverse effects of the progestogens contained in current OCs on the lipoprotein profile and their atherogenic effect on the vessel wall seem effectively counterbalanced by the estrogen content of these new OCs. However, the progestin content seems still responsible for a low level of chronic insulin resistance, which might be related to vascular alterations potentially linked to syndrome-X. In conclusion, reduced metabolic effects of new low-dose OCs appear to decrease their atherogenic risk. However, thrombotic effects dose-related to the estrogen component of OCs are still persisting and seem less easily suppressible.

Arteriosclerosis↗
PubMed1991

Variations of luteinizing hormone serum concentrations after exogenous human chorionic gonadotropin administration during ovarian hyperstimulation.

Changes in luteinizing hormone (LH), estradiol, and progesterone (P) serum levels before and after preovulatory administration of human chorionic gonadotropin (hCG) were assayed in 30 patients stimulated with clomiphene citrate (CC) and human menopausal gonadotropin (hMG) and compared with LH variations in 43 patients submitted to pharmacological hypophysectomy with a gonadotropin-releasing hormone agonist (GnRH-a) and stimulation with hMG. In CC + hMG-treated patients, an endogenous LH surge occurred systematically 4.25 +/- 2.75 hours after hCG injection. Multiparametric analysis indicated an inverse correlation between the delay in the initial rise of the LH surge and the increase in P levels during the 6 hours after hCG administration. Gonadotropin-releasing hormone agonist + hMG treatment did not lead to an LH surge after hCG but to a significant fall in LH levels. Thus, exogenous hCG, administered before ovulation, induces an endogenous LH surge if pituitary function is not blocked by a GnRH-a, probably through an increase in P secretion.

Adult↗
PubMed1990

Single dose fosfomycin trometamol versus multiple dose nitrofurantoin in pregnant women with bacteriuria: preliminary results.

Pregnancy induces anatomical and physiological changes in the urinary tract. In this condition a bacteriuria, even asymptomatic, may lead more frequently to pyelonephritis. Asymptomatic bacteriuria in pregnant women has therefore got to be treated. According to recent studies, long course antibiotherapy did not prove to be more effective than a single-dose one in the case of non-complicated bacteriuria. Moreover, the maternal and foetal toxicity should be reduced in the latter regimen. In this paper we present the preliminary results of our study comparing a single-dose treatment by fosfomycin trometamol (3 g) and nitrofurantoin (200 mg per day during a week).

Administration, Oral↗
PubMed1990

Immunodetection of the metastasis-associated laminin receptor in human breast cancer cells obtained by fine-needle aspiration biopsy.

Fine-needle aspiration biopsy of the breast is a very useful technique for the evaluation of a suspect lesion before surgical removal. Increased expression of the 67-kd laminin receptor has been associated with the metastatic phenotype of cancer cells, particularly in colon and breast cancers. In this study, the expression of laminin receptor was evaluated using the immunoperoxidase technique in 81 breast aspirates (26 benign and 55 neoplastic lesions). Cells obtained from benign samples exhibited a low level of laminin receptor antigen detected by affinity-purified antibody raised against a cDNA-derived laminin receptor peptide. In contrast, 71% of smears obtained from malignant breast lesions contained cells that were strongly stained by the antibody. Heterogeneous expression of the laminin receptor was noted in both breast aspirates and fixed tissue specimens. These data suggest that the immunodetection of laminin receptor in cells obtained by fine-needle aspiration of breast lesions could be a valuable adjunct in the prognostic evaluation of breast lesions.

Antibodies↗