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Biomedical subjects

R Lahl

Publications and source records attributed to R Lahl.

At least 55 records · Page 3Linked to original sources
PubMed1977

[Spinal manifestations of sarcoidosis].

This is a report on the spinal manifestation of sarcoidosis, which has heretofore been infrequently dealt with in the specialized literature. In addition to diffuse manifestation, there has become known circumscribed and solitary manifestation with tumorous symptomatology as a result of spinal compression. Transverse syndromes, pareses, manifestations of sensibility, and disorders of the bladder and rectum are of major clinical importance in this connection. Pathomorphologically, it is possible to distinguish granulomatous leptomeningitis, myelitis, and (poly-) radiculitis, combined simultaneous involvement being frequently observed. So far as differential diagnosis is concerned, considerable difficulties are encountered especially in the case of isolated spinal monosymptomatology. Prognosis, because of special topographic conditions, is less favorable than for other organic manifestations. Secondary phenomena and complications are often responsible for the consequences of spinal sarcoidosis. In addition to spontaneous healing, treatment with corticosteroids (of acute disease processes which, however, are a relatively rare occurrence) and surgical operation (in the case of solitary spinal sarcoid granulomata with compression syndromes) have proven to be most successful.

Diagnosis, Differential↗
PubMed1977

[Multiple sex drive abnormalities in a patient with Klinefelter's syndrome].

The authors report various sexual instinct disturbances and, more specifically, exhibitionism and pedophilia of a 25-year-old patient with Klinefelter's syndrome. The patient had committed several punishable offenses and was referred to our specialty clinic for psychologic and psychiatric examinations. Aspects of psychopathology and causal etiopathogenetic relationships of the authors' own observations are discussed and compared with those reported in the literature. Environmental factors are considered to be primarily responsible for the development of sexual perversions. The Klinefelter syndrome as such may be regarded as being of predispositional importance only.

Adult↗
PubMed1977

[Cerebrospinal sarcoidosis (with reference to 2 personal cases)].

Two cases of leptomeningo-cerebro(-spinal) sarcoidosis which were not clinically diagnosed in two women (22 and 33 years old) are described. The two women died because of this disease, 8 months, and 1 1/2 years, resp., after the first manifestation. In the first case there was a largely isolated local affection of the hypothalamus and neurohypophysis. In the second observation, beside an involvement of the bifurcate lymph nodes and of the lungs, it was only the central nervous system that showed massive diffuse changes partially due to a granulomatous angiitis of cerebral and visceral vessels. On the basis of pathohistology, the differential diagnosis to the histiocytosis X for case 1 and to the granulomatous giant cell angiitis for case 2 are discussed.

Adult↗
PubMed1976

[Unusual paraventricular cavitations as complication of brain stem glioblastoma].

The author in his present paper reports extensive paraventricular cavitation of the lateral ventricles in a 24-year-old woman with a brain-stem glioblastoma. Playing an important etiopathogenetic role in the development of this particular complicatien are a disturbance of the pischarge of liquor due to the expansion in the posterior cranial fossa of the rapidly growing tumor, the internal hydrocephalus resulting therefrom, and the acute tumoral hemorrhage accompanied by an invasion of the fourth ventricle and partial internal hematocephalus.

Adult↗
PubMed1976

[The pathomorphology of the arteria primitiva trigemina, together with some critical comments on the pathomorphology of its adjacent structures and the morphological cerebral complications (author's transl)].

In the light of six self-reported observations an account is given on the pathomorphology and pathohistology of the arteria primitiva trigemina including morphological changes of neighbouring organs and tissue structures as well as of the brain which are directly casused by the anastomosis. Furthermore, our own findings and those described in the pertinent literature are compared. In three of our own cases considerable calcification of the intima and media of the persistent artery have been demonstrated histologically, On the other hand only a slight involvement of the blood vessel from which it originates and of that one into which it flows as well as of the other arteries of the base of the brain has been observed. This suggests to be the result of special flow and pressure relationships of the blood, and interpreted as locus minoris resistentiae. The discrepancy between the frequency of the neuroradiological demonstration and the clinico-neuropathophysiological importance of the anastomosis, on the one hand, and the obtaining of neuropathological autopsy findings, on the other, has been pointed out.

Adult↗
PubMed1975

[The morphology of the CNS in carbon tetrachloride poisoning. 6. Histology of spinal ganglia in the lumbosacric region (experimental studies) (author's transl)].

As a further report on our investigations concerning the effects of carbon tetrachloride intoxication the histological findings in lumbosacric ganglia of 48 rabbits are presented. The substance was applied perorally as well as a subcutaneously to 24 animals in each group. Detectable alterations were weak and consisted of pathobioses and pathonecroses of the ganglion cells and, partly as a consequence of these lesions, of an activation of glial elements. In most of the test animals as well as in 10 of the 11 controls cytoplasmic vascuoles were found. From the pathogenetic point of view the impairment of elementary cell functions by anoxemia both with primary and secondary hepatorenally caused lesions may be of major importance.

Animals↗
PubMed1975

[Giant cell arteritis and the CNS. Summary of special considerations in two separate cases].

This is a report on two fatal cases of giant-cell arteritis (GCA) with isolated involvement of intracranial arteries. The peculiarities as observed by the author in two 42-year-old male patients from his own material, are the relatively young age of these patients, the duration of illness amounting to six weeks and 14 months respectively, which is unusually short for vascular processes; and substantial cerebral circulation disturbances caused by inadequate oxygen supply. The symptomatology, the special clinical and neurological findings, the distribution patterns of the extra- and intracranial vascular involvement, including the dysfunctions as caused therby, as well as pathogenesis, aetiology, and considerations concerning the differential diagnosis are reported and compared with those to be found in the literature.

Adult↗
PubMed1975

[Space-occupying cerebral process as a clinical misdiagnosis in subacute spongioid encephalopathy (Jakob-Creutzfeldt syndrome). Clinical-morphological report on 3 cases].

This is a report on three cases of subacute spongioid encephalopathy (Jakob-Creutzfeldt syndrome) where an extended cerebral process had been diagnosed clinically. However, a final and correct diagnosis could not be established until after the postmortem examination. The patients were 1 woman and 2 men; the duration of disease was between 5 weeks and 2 1/2 years. In 2 of the patients, initial pseudoneurasthenic complaints were followed, in the further course of disease, by manifestations of an organic psychosyndrome accompanied by neurological and, moreparticularly, coordination disorders. The neuropathological conditions manifested themselves especially in the frontal and occipital cortices as spongioid states, astroglial changes, ganglion-cell failures and pathobioses.

Brain Neoplasms↗