Biomedical subjects

R L Wolf

Publications and source records attributed to R L Wolf.

At least 55 records · Page 3Linked to original sources

PubMed1977

An inhibitor of lymphocyte proliferation and lymphokine production released by unstimulated foetal monocytes.

Supernatants obtained from 3-day cultures of cord blood monocytes inhibited normal lymphocyte activation by either PHA or in a two-way MLC. Both lymphocyte transformation and lymphokine production was significantly inhibited by these supernatants but not by those derived from adult mononuclear cell cultures. The inhibitory material produced by foetal monocytes was dialysable and was non-cytotoxic to target cells. It is postulated that this factor contributes to the depressed maternal cell-mediated immune response observed in pregnancy.

Female↗

PubMed1976

An unusual experience of neonatal necrotising enterocolitis.

Fifty-three patients with neonatal necrotising enterocolitis, who were seen over a 1-year period, were reviewed with regard to weight, gestational age, type of feed and incidence of exchange transfusion. These babies were larger and more mature than those in whom this disease is usually described. A significantly smaller number of babies with necrotising enterocolitis than control babies were breast-fed. A high positive association with exchange transfusion was noted.

Enterocolitis, Pseudomembranous↗

PubMed1976

Production of leucocyte migration inhibitory factor by neonatal lymphocytes.

Lymphocytes (mononuclear cells) from cord blood of 10 normal placentas and from 10 normal adults were assessed for production of leucocyte migration inhibiting factor (LIF) after phytohaemagglutinin (PHA) stimulation, as a measure of cell-mediated immunity. Mononuclear cells from both adult and cord blood produced adequate quantities of LIF, indicating that neonatal lymphocytes have the ability to manufacture normal amounts of lymphokines.

Adult↗

PubMed1976

Prolonged rupture of fetal membranes and neonatal infections.

Fifty-one babies with prolonged rupture of fetal membranes (longer than 24 hours) were studied for evidence of latent infection. Cord blood was taken from all babies for a full blood count and blood culture. Gastric aspirates were collected and vernix swabs were taken immediately after delivery. Microscopy, culture and antibiotic sensitivity tests were done on the appropriate specimens. Each baby had a thorough medical examination immediately after birth, and 3 and 7 days afterwards. After the initial investigation they were allocated to a treatment (penicillin 50 000 U/kg/d and kanamycin 10 mg/kg/d) or a non-treatment group by randomised card selection. Six patients became infected, as was shown by a positive blood culture, while 4 of the 6 had clinical signs of infection as well. These infants were treated with penicillin and kanamycin, and all did well. None of the remaining babies showed any signs of infection. There were no deaths. Blood culture was found to correlate well with clinical infections, and many be used as a guide to latent infection and treatment.

Bacterial Infections↗

PubMed1975

Phaeochromocytoma in childhood. A case report.

The clinical features of a 9-year-old boy with an extra-adrenal phaeochromocytoma, complicated by malignant hypertension, are described. The value of urinary and blood catecholamine assays and specialised radiological investigations in the accurate localisation of the tumour, is emphasised. Successful removal of the tumour was facilitated by pre-operative control of the hypertension with a combination of alpha and beta-adrenergic blockade (phenoxybenzamine and practolol). Intra-operative control of fluctuations in blood pressure was simplified by the use of Ethrane (enflurane compound 347) as one of the anaesthetic agents. As a result, sodium nitroprusside was infrequently used.

Anesthesia, General↗

PubMed1975