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Biomedical subjects

R L Wilson

Publications and source records attributed to R L Wilson.

85 records · Page 5Linked to original sources
PubMedDate not supplied

CD8+ T cells in intracellular bacterial infections of mice.

In the normal course of an immune response, both CD4+ and CD8+ T cells respond to each of the bacterial pathogens we have discussed and both responses may be required for the most potent immunity to infection. In this discussion, we have focused on the ability of these organisms to prime CD8+ T-cell responses in vivo and the ability of CD8+ T cells as sole mediators of acquired immunity, to protect against infection. It is clear that the vacuolar location of bacterial pathogens such as Salmonella or Mycobacteria does not prevent in vivo priming of CD8+ T-cell responses to these pathogens. However, vacuolar localization may affect the potency of CD8+ T-cell responses under experimental conditions that assess the capacity of CD8+ T cells as the sole mediators of acquired immunity. In the case of cytoplasmic L. monocytogenes, clear evidence exists that antigen-specific CD8+ T cells, in the absence of immune CD4+ T cells, can provide substantial acquired immunity to naive mice. Similar clear experimental results with Salmonella and Mycobacteria are lacking. Such results would provide stronger support for vaccines that elicit CD8+ T-cell responses to these vacuolar pathogens. Although our discussion has focused on only three specific organisms, we suggest that detection of an in vivo CD8+ T-cell response to a bacterial antigen does not ensure that the response will be protective against infection in a vaccine setting. In the case of Salmonella and Mycobacteria, this issue remains unresolved.

Animals↗
PubMedDate not supplied

Optimizing nutrition for patients with cancer.

Malnutrition is the most common secondary diagnosis in patients with cancer and is a major prognostic indicator for poor response to cancer therapy and shortened survival. The word CANCER can be used as an acronym to guide early nutritional intervention that combines an understanding of cancer cachexia with a plan to optimize patients' nutritional status during the stress imposed by cancer and its treatment. Conversations with patients reveal nutrition-related information that is valuable as part of a comprehensive assessment. The Assessment combines nutrition-related information with observations made during the conversation. The Nutrition plan is developed to meet patients' identified nutritional needs. The goals of the cancer treatment dictate the aggressiveness of nutritional support. An awareness of potentially life-threatening Complications of enteral and parenteral nutrition is essential. An ongoing Evaluation of patients' status and responses to the nutrition plan guides changes to the plan as needed. Reassurance/Removal are important parts of care during all stages of treatment and nutrition support.

Humans↗
PubMedDate not supplied

Effect of dietary histamine on broiler chickens infected with avian reovirus S1133.

One-day-old broiler chickens were infected with either of two vaccine strains of avian reovirus S1133 and fed diets containing 0.2% histamine dihydrochloride for 21 or 35 days. Control groups received either or neither of these treatments. The most notable virus-histamine interaction observed was increased (P less than 0.01) early mortality of chickens infected with the more virulent (pullet) vaccine virus. Histamine in the diet did not affect seroconversion rates or the incidence of stunting in virus-infected chickens. Other evidence of virus-histamine interaction was proventricular enlargement and decreased (P less than 0.05) weight gains in chickens infected with the less virulent (chick) vaccine virus, but these signs were observed inconsistently. The possible clinical significance of these observations is discussed.

Animals↗